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Effect of JC Virus on Polyomavirus Nephropathy in Renal Transplant Recipients

G. Huang, Y. Huang, X. Chen, J. Qiu, J. Li, C. Wang, L. Chen

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Meeting: 2020 American Transplant Congress

Abstract number: D-181

Keywords: Biopsy, Graft function, Kidney/liver transplantation, Polyma virus

Session Information

Session Name: Poster Session D: Kidney: Polyoma

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: To investigate the effect of JC virus (JCV) on the development and prognosis of BK virus (BKV) infection and polyomavirus nephropathy (PVN) in renal transplant recipients.

*Methods: A total of 196 renal transplant recipients who underwent graft biopsy in our hospital from May 2017 to December 2018 were divided into PVN group (n = 69) and non-PVN group (n = 127). The differences of infection rate and replication level of JCV and BKV between the two groups were compared, while the effects of JCV on the pathological degree of PVN and the relationship between JCV and graft survival rate and function of PVN recipients were investigated.

*Results: In PVN and non-PVN groups, 69 cases (100%) and 35 cases (27.6%) were infected with BKV (P<0.001), 22 cases (31.9%) and 48 cases (37.8%) were infected with JCV (P=0.409), respectively. In PVN and non-PVN groups, the median level of BKV-DNA in plasma was 4.06×104 and 2.49×103(P=0.014), that in urine was 1.4×109 and 2.64×106 (P<0.001), respectively; meanwhile, the median level of JCV-DNA in urine was 1.3×108 and 2.87×106 (P=0.065), that in plasma was 2.43×104 and 0 (P=0.016), respectively. In the PVN group, there was no significant correlation between JCV level and the scores of main pathological parameters (t, ct, i, ci and SV40-T extent) (all P>0.05). While there is a positive linear correlation between JCV and BKV level (r=0.478, p=0.025). The creatinine level in PVN recipients with JCV viremia one year after biopsy was significantly higher than that of non-JCV viremia recipients (P=0.041).

*Conclusions: JCV plays a positive role in promoting BKV replication among PVN recipients. It is recommended to monitor plasma JCV-DNA in recipients with PVN.

Infection of BKV and JCV in plasma and urine among 196 recipients
Items BKVN(n=69) Non-BKVN(n=127) P
BKV-DNA in urine, median copies/ml 1.4×109(4.6×105~1.0×1011) 2.64×106(6.56×102~3.8×1010) <0.001
BKV-DNA in plasma, median copies/ml 4.06×104(5.0×102~1.61×106) 2.49×103(2.05×102~4.08×105) 0.014
JCV-DNA in urine, median copies/ml 1.3×108(1.64×103~2.06×109) 2.87×106(1.51×103~2.31×1010) 0.065
JCV-DNA in plasma, median copies/ml 2.43×104(1.23×103~3.06×105) 0(0) 0.016
BKV Viruria, n (%) 69(100%) 35(27.6%) <0.001
BKV Viremia, n (%) 43(62.3%) 7(5.5%) <0.001
JCV Viremia, n (%) 8(11.6%) 0(0%) <0.001

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To cite this abstract in AMA style:

Huang G, Huang Y, Chen X, Qiu J, Li J, Wang C, Chen L. Effect of JC Virus on Polyomavirus Nephropathy in Renal Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-of-jc-virus-on-polyomavirus-nephropathy-in-renal-transplant-recipients/. Accessed May 11, 2025.

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