ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)TM Liver: A Single Center Experience

J. Konel1, M. Shamaa2, O. Shamaa2, A. Elsabbagh2, T. Kitajima2, T. Ivanics2, K. Delvecchio2, A. Mohamed2, S. Yeddula2, K. Collins2, A. Yoshida2, M. Abouljoud2, S. Nagai2, M. Rizzari2

1Wayne State University School of Medicine, Detroit, MI, 2Henry Ford Transplant Institute, Detroit, MI

Meeting: 2021 American Transplant Congress

Abstract number: 1256

Keywords: Liver, Lung, Preservation, Preservation solutions

Topic: Clinical Science » Organ Inclusive » Non-Organ Specific:Organ Preservation/Ischemia Reperfusion Injury

Session Information

Session Name: Non-Organ Specific: Organ Preservation/Ischemia Reperfusion Injury

Session Type: Poster Abstract

Session Date & Time: None. Available on demand.

Location: Virtual

*Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who cannot survive single-organ transplantation alone. Ex-situ normothermic machine perfusion (NMP) has been used to increase the pool of suboptimal donors and has been previously used for extended normothermic lung preservation in CLLT. We aim to describe our single-center experience using the ‘Transmedics Organ Care System (OCS) ™ liver’ for extended normothermic liver preservation in CLLT.

*Methods: Medical records were queried for patients at our center that underwent CLLT from 2015-2020.

*Results: [Values shown are represented as mean (standard deviation, range)]: Four CLLTs were performed from 2015 to 2020 including 3 male and 1 female recipients, age 50 (±13.7, 31-61) years (Table 1). Indications for lung transplantation include: (1) cystic fibrosis (CF), (1) severe bronchiectasis, and (2) interstitial pulmonary fibrosis. Indications for liver transplantation include: (1) biliary cirrhosis secondary to CF, (1) cirrhosis secondary to autoimmune hepatitis, (1) alcoholic cirrhosis, and (1) cryptogenic cirrhosis. The lung was transplanted first for all patients. Recipient characteristics at transplant: Mean forced expiratory volume in 1 second (FEV1) was 51% (±22, 29-78) and Model for End-Stage Liver Disease was 12 (±3.7, 8-16). The livers were donated after brain death with donor age of 34 (±9.4, 25-46) years and cold ischemia time 566 (±38, 545-623) minutes. Ex-vivo pump time for the livers was 411 (±38, 364-456) minutes (Table 2). Mean hospital stay was 34 days (±18, 14-161). Over a median follow-up of 201 days, patient and graft survival remain at 100%, though 50% of liver grafts had biopsy-proven acute cellular rejection.

*Conclusions: CLLT is a viable treatment option for patients with severe two-organ failure. Normothermic extended liver preservation is a safe method to prolong perfusion time and preserve the liver during combined liver and lung transplantation.

 border=

 border=

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Konel J, Shamaa M, Shamaa O, Elsabbagh A, Kitajima T, Ivanics T, Delvecchio K, Mohamed A, Yeddula S, Collins K, Yoshida A, Abouljoud M, Nagai S, Rizzari M. Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)TM Liver: A Single Center Experience [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/combined-liver-and-lung-transplantation-with-extended-normothermic-liver-preservation-using-transmedics-organ-care-system-ocstm-liver-a-single-center-experience/. Accessed May 31, 2025.

« Back to 2021 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences