Articles tagged "Preservation solutions"

2022 American Transplant Congress
Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo
P. Luke¹, A. Jackson², A. Ruthirakanthan², S. Juriasingani², M. Levine¹, L. Jiang², R. Patel², M. Richard-Mohamed¹, S. Forrest¹, A. Sener¹, R. N. Bhattacharjee¹
¹London Health Sciences Centre, London, ON, Canada, ²Western University, London, ON, Canada
*Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…
2022 American Transplant Congress
Regulation of Cell Death During Cold Preservation of Marginal Human Kidneys
J. R. DiRito¹, G. Chickering¹, J. Langford¹, D. Stern¹, D. Qin², S. Hosgood³, M. Nicholson³, J. Pober⁴, E. Gavathiotis⁵, R. Kitsis⁵, G. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Albert Einstein College of Medicine, Bronx, NY, ³Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Immunology, Yale School of Medicine, New Haven, CT, ⁵Albert Einstein College of Medicine, Bronx, NM
*Purpose: Each year thousands of kidneys from marginal donors are discarded due to an increased sensitivity to injury during cold storage and consequently a high…
2022 American Transplant Congress
Analysis of Antibiotic Resistance and Risk Level of Preservation Fluid Microorganisms in Kidney Transplant Recipients
J. Li¹, X. Su¹, J. Han², Y. Huang², W. Wu¹, M. Wei², S. Yuan², C. Wu¹, J. Li¹, L. Liu¹, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: As a solution for preserving kidney during procurement and transportation, preservation fluid (PF) is the main method to detect donor-derived infection. But there are…
2022 American Transplant Congress
Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, J. Hodrea¹, L. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…
2022 American Transplant Congress
Pretransplant microRNAs in Liver Perfusate Associate with Early Allograft Dysfunction
E. Bardhi, E. Williams, J. McDaniels, T. Rousselle, V. Mas, D. Maluf
University of Maryland School of Medicine, Baltimore, MD
*Purpose: Early allograft dysfunction (EAD) in liver transplantation (LT) is associated with poor long-term graft and patient survival. Prior to LT, while organs are stored…
2021 American Transplant Congress
Sigma-1 Receptor Agonists are Renoprotective in Experimental Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, D. Balogh¹, J. Hodrea¹, L. J. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a…
2021 American Transplant Congress
The Harmful Effect of Retained Peripheral Cells During Flushing and Static Cold Storage in Rat Liver Normothermic Machine Perfusion
O. Haque¹, C. A. Pendexter², J. F. Markmann², K. Uygun², H. Yeh², S. N. Tessier²
¹Surgery, Beth Israel Deaconess Medical Center, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: Retained donor blood in a liver graft can cause damage to resident cells that is exacerbated by static cold storage (SCS), leading to platelet…
2021 American Transplant Congress
Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results
L. I. Mazilescu¹, P. Urbanellis¹, J. S. Kim¹, A. Konvalinka¹, T. W. Reichman¹, L. A. Robinson², A. Ghanekar¹, M. Selzner¹
¹Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
2021 American Transplant Congress
Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)^TM Liver: A Single Center Experience
J. Konel¹, M. Shamaa², O. Shamaa², A. Elsabbagh², T. Kitajima², T. Ivanics², K. Delvecchio², A. Mohamed², S. Yeddula², K. Collins², A. Yoshida², M. Abouljoud², S. Nagai², M. Rizzari²
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Transplant Institute, Detroit, MI
*Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who cannot survive single-organ transplantation alone. Ex-situ normothermic machine perfusion (NMP) has been used to increase…
2020 American Transplant Congress
The Effect of Pulsatile Pump Perfusion on Hepatitis C Viremia and Transmission in Kidney Transplantation: A Prospective Pilot Study
R. Forbes¹, B. Concepcion¹, D. Clapper², B. Dubray¹, A. Miller², D. Shaffer¹, K. Johnson²
¹Vanderbilt University Medical Center, Nashville, TN, ²Tennessee Donor Services, Nashville, TN
*Purpose: With increasing utilization of hepatitis C (HCV) viremic donor organs for aviremic recipients, there may be a role for kidney pulsatile pump perfusion to…