Articles tagged "Preservation solutions"

2018 American Transplant Congress
Supercooling of Human Livers to Extend the Preservation Time for Transplantation
R. de Vries,^1,2 S. Tessier,^1,2 P. Banik,^1,2 S. Ozer,^1,2 S. Napgal,^1,2 S. Cronin,^1,2 J. Markmann,^1,2 H. Yeh,^1,2 K. Uygun.^1,2
¹Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Center for Engineering in Medicine, Harvard Medical School, Boston, MA.
Introduction: Extending the maximum preservation time of donor organs could dramatically improve the outcome of organ transplantation. Static cold storage (SCS) at +5[deg]C is the…
2018 American Transplant Congress
Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury
A. Panisello-Rosello,¹ A. Lopez,² C. Castro,² S. Bellogi,¹ E. Folch-Puy,¹ A. Rolo,³ C. Palmeira,³ R. Adam, J. Roselló-Catafau.
¹Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona, Barcelona, Catalonia, Spain; ²INSERM U935, Hôpital Paul Brousse, Paris, France; ³Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Aldehyde dehydogenase (ALDH2) is a mitochondrial enzyme that recently has been involved in the cardioprotection against ischemia injury. No data are reported on the potential…
2018 American Transplant Congress
Ex-Vivo Subnormothermic Oxygenated Machine Perfusion of Rodent Hindlimb: Feasibility Study to Elongate Preservation Time of Vascularized Composite Allograft
L. Burlage,^1,2 A. Lellouch,^3,4 S. Tessier,¹ C. Pendexter,¹ S. Cronin,¹ M. Schol,³ M. Randolph,³ R. Porte,² L. Lantieri,⁴ C. Cetrulo,³ K. Uygun.¹
¹Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; ²Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Plastic Surgery, Massachusetts General Hospital/Harvard Medical School, Boston; ⁴Plastic Surgery, European George Pompidou Hospital, Paris, France.
PURPOSE: A pressing challenge in the field of VCA is adequate tissue preservation. Static cold preservation, successfully used in field of solid organ transplantation, greatly…
2018 American Transplant Congress
Ex Vivo Bloodless Oxygen Carrier for Perfusion of DCD Kidneys during Subnormothermic Storage
P. Luke,^1,2 M. Richard-Mohamed,² A. Haig,³ R. Mayer,² S. Aquil,² A. Sener,² A. Jevnikar,^1,2 R. Bhattacharjee.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.
Background: Non-oxygenated static or machine perfusion in cold (4[deg]C) remains the gold standard in transplantation and an optimal method of oxygen delivery to ischemic kidneys…
2018 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses Acute Allograft Rejection and Prolongs Graft Survival in Murine Heart Transplantation
T. Tanaka, T. Maehana, N. Masumori.
Department of Urology, Sapporo Medical University, Sapporo, Japan.
Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor to recipients prolonged the allograft survival in murine skin and…
2017 American Transplant Congress
Steatotic Human Livers Show Inferior Function Compared to Non-Steatotic Livers During Ex-Situ Viability Assessment by Oxygenated Machine Perfusion.
N. Karimian,¹ V. Huang,¹ F. Fontan,¹ M. Aburawi,¹ S. Geerts,¹ S. Mert,¹ I. Beijert,² R. Porte,² M. Yarmush,¹ K. Uygun,¹ J. Markmann,¹ H. Yeh.¹
¹Division of Transplantation, Massachusetts General Hospital, Boston; ²Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands
Fatty livers are frequently declined for transplantation due to high risk of primary non-function. Ex-situ oxygenated machine perfusion (MP) is superior to static cold storage…
2017 American Transplant Congress
Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.
M. Thomas, G. Tardif, A. Melanger, P. Berna.
Balmes Transplantation, Marseille, France
Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…
2017 American Transplant Congress
Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.
F. Fontan, M. Aburawi, N. Karimian, K. Uygun, F. Delmonico, H. Yeh, J. Markmann.
Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background: Hypothermic non-oxygenated machine perfusion (HMP) is commonly used in kidney preservation, providing some advantage over static cold storage, as well as flow and resistance…
2016 American Transplant Congress
SLPI in the Perfusion Liquid: A Predictor Marker of Short and Long Term Clinical Outcomes.
A. Dotta,¹ F. Caro,² K. Peña Ponce,¹ N. Ambrosi,² J. Salaberry,² X. García,¹ E. Minué,¹ L. León,¹ F. Sánchez,² F. Togniolo,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrología, Caba, Argentina; ²CEFYBO-UBA, Caba, Argentina; ³Fundación GADOR, Caba, Argentina.
A lot of efforts have been done to identify the risk factors that tend to diminish the incidence of delayed graft function (DGF). Recently, the…
2016 American Transplant Congress
Storage Kidneys Prior to Transplantation Using First Polish Preservation Solution "Biolasol" – Preliminary Report.
A. Jozwik,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Bieniasz,¹ M. Serwanska-Swietek,¹ M. Durlik,² F. Ryszka,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Departments of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland; ³BIOCHEFA, Sosnowiec, Poland.
One of the factors affecting function of the transplanted organ is a method of its storage. The aim of the study is to evaluate the…