Articles tagged "Malignancy"

2019 American Transplant Congress
Hepatoblastoma Tumors Requiring Liver Transplantation Manifest Dysregulated Ciliary, Autophagy and Cell Cycling Pathways in Systems Biology Analysis
T. Narayanan¹, M. Ningappa², B. W. Higgs², S. Subramaniam³, R. Sindhi²
¹Bioenginering, University of California, San Diego, CA, ²Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³University of California, San Diego, CA
*Purpose: Liver transplantation (LT) can cure locally invasive, unresectable and chemo-resistant hepatoblastoma (HBL), an embryonal liver tumor of infancy. Post-LT immunosuppression enhances recurrence-risk despite chemotherapy.*Methods:…
2019 American Transplant Congress
Pathologic Vascular Invasion Correlates with Worse Outcome in Hepatoblastoma Patients Treated with Liver Transplantation – A Hepatoblastoma Transplant Consortium Study
T. H. Malik¹, H. Zhu², T. Ha³, S. Commander⁴, C. Trautz⁵, R. Sindhi⁵, S. Kim⁶, K. Vakili⁶, N. Vachharajani⁷, W. Chapman⁷, A. Griesemer⁸, M. Martinez⁸, J. A. Goss⁹, S. Vasudevan¹⁰
¹Baylor College of Medicine, Houston, TX, ²Texas Children's Hospital, Houston, TX, ³Department of Surgery, Baylor College of Medicine, Houston, TX, ⁴Department of Surgery, Duke University School of Medicine, Durham, NC, ⁵Department of Surgery, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Surgery, Boston Children's Hospital, Boston, MA, ⁷Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, ⁸Department of Surgery, NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, ⁹Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, ¹⁰Department of Pediatric Surgery, Texas Children's Hospital, Houston, TX
*Purpose: Orthotopic liver transplant (OLTx) is the most common method to treat unresectable hepatoblastoma (HB) in children. There is limited data focusing on the outcomes…
2019 American Transplant Congress
Relationship between Comorbilities and Infectious Disease in Kidney Transplant Recipients Receiving Rituximab
A. Molina-Andújar¹, E. Hermida¹, J. Rovira², F. Cofan¹, P. Ventura-Aguiar¹, N. Esforzado¹, V. Torregrosa¹, D. Cucchiari¹, E. de Souza¹, I. Revuelta¹, F. Oppenheimer¹, F. Diekmann¹, G. Piñeiro¹
¹Renal Transplant Unit, Hospital Clínic de Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain
*Purpose: Rituximab is commonly used in the context of kidney transplantation. Evidence about infectious complications and its relationship with predictive factors is scarce. The aim…
2019 American Transplant Congress
The Safety Of Adjuvant Chemotherapy In Kidney Transplant Patients With Urothelial Carcinoma
Z. Wang, J. Xiao, Y. Zhu, J. Lin, Y. Guo, Y. Tian
Capital Medical University，Beijing Friendship Hospital, Beijing, China
*Purpose: The purpose of the present study was to evaluate the safety of adjuvant chemotherapy with gemcitabine plus cisplatin in kidney transplant patients with urothelial…
2019 American Transplant Congress
The Response to Human Papillomavirus Vaccination in Pediatric Patients before and after Kidney Transplantation
C. Nailescu¹, R. D. Nelson², K. Twombley³, P. S. Verghese⁴, A. S. Chishti⁵, M. Mills⁶, J. E. Slaven⁷, J. D. Mahan⁸, M. L. Shew¹
¹Riley Hospital for Children, Indianapolis, IN, ²Primary Children’s Hospital, Salt Lake City, UT, ³MUSC Children’s Hospital, Charleston, SC, ⁴Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, ⁵Kentucky Children’s Hospital, Lexington, KY, ⁶C.S. Mott Children’s Hospital, Ann Arbor, MI, ⁷Indiana University, Indianapolis, IN, ⁸Nationwide Children’s Hospital, Columbus, OH
*Purpose: Kidney transplant (KT) recipients have an increased incidence of malignancies, including Human Papillomavirus (HPV)-associated cancers. Thus, HPV vaccines may have an important role in…
2019 American Transplant Congress
Clinical Outcomes of Using mTOR Inhibitors with Reduced Dose of Calcineurin Inhibitors in Lung Transplant Recipients: A Single Center Experience
M. Frawley¹, J. Leedy¹, A. James¹, A. Salter¹, V. Rusanov²
¹Department of Pharmacy, UAB Hospital, Birmingham, AL, ²Division of Pulmonary, Allergy, and Critical Care Medicine, UAB Hospital, Birmingham, AL
*Purpose: The use of mammalian target of rapamycin inhibitors (mTORi) in cardiothoracic transplantation has significantly increased over the past decade. Several recent clinical trials have…
2019 American Transplant Congress
Ex Vivo Resection And Autologous Liver Transplantation As Management Concept For Extensive Malignancy
K. Bruestle¹, A. Griesemer², S. Lobritto², M. Martinez², J. Vittorio², D. Yamashiro², E. Bacha³, T. Kato²
¹Columbia Center for Translational Immunology, Columbia University, New York City, NY, ²Columbia Center for Liver Disease and Transplantation, Columbia University Medical Center, New York City, NY, ³Morgan Stanley Children's Hospital, Columbia University Medical Center, New York City, NY
*Purpose: Neuroblastomas are rare neural crest derived tumors which contribute disproportionally to childhood morbidity and mortality. Surgical resection remains standard treatment, however adequate resection is…
2019 American Transplant Congress
Donor Derived Neoplasia: Will It Be a Risk after Clinical Pig Organ Xenotransplantation?
A. Jagdale¹, H. Iwase¹, E. Klein², D. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The survival of the nonhuman primates with life-supporting pig kidney grafts has increased substantially (to >1 year). As clinical pig organ xenotransplantation draws closer,…
2019 American Transplant Congress
Insurance Status Impacts Treatment for Hepatocellular Carcinoma
L. Sobotka¹, A. Hinton², L. Conteh¹
¹Gastroenterology, Hepatology and Nutrition, The Ohio State Wexner Medical Center, Columbus, OH, ²The Ohio State University, Columbus, OH
*Purpose: Previous studies have identified treatment disparities in the treatment of hepatocellular carcinoma (HCC) based on insurance status and provider. Recent studies have shown more…
2019 American Transplant Congress
The Impact of Acute Rejection in Heart Transplantation on Post-Transplant Malignancy
K. Kamrani¹, A. Okoh², D. Hanos¹, M. Camacho¹, M. Zucker², K. Clarke¹
¹Dept. of Surgery, Newark Beth Israel Medical Center, Newark, NJ, ²Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ
*Purpose: Compared with the general population, an increased incidence of skin cancers and lymphomas have been shown in orthotopic heart transplant (OHT) recipients. However, the…