Date: Sunday, May 3, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Purpose: Hyperlipidemia is common in renal transplant recipients (RTR) during calcineurin inhibitor (CNI) immunosuppression. P-glycoprotein (P-gp) is an efflux transporter encoded by ABCB1 that modulates lipid transport, statin response and CNI exposure with a primary variant (TTT) associated with reduced function compared to wild-type (CGC). This study evaluated ABCB1 haplotypes, sex, CNI regimen and lipid profiles among RTR.
Methods: A prospective, cross-sectional study was completed in 149 stable RTR (estimated glomerular filtration rate 51±17ml/min/1.73m2) receiving cyclosporine (CYA) and mycophenolic acid (MPA; n=82) or tacrolimus (TAC) and MPA (n=67) for ≥ 6 months. Lipid profiles were obtained after 12-hour fast. The ABCB1 single nucleotide polymorphisms (SNP): c.1236C>T (rs1128503), c.2677G>T (rs2032582), and c.3435C>T (rs1045642) were determined and haplotype associations estimated by THESIAS.
Results: Lipids are summarized (Table) by sex and CNI.
|CYA+MPA (n=82)||TAC+MPA (n=67)|
|Lipid Parameter||Male (n=67)||Female (n=14)||Male (n=38)||Female (n=29)||P-value|
|TCH (mg/dL)||182 ± 47||223 ± 57||152 ± 48||163 ± 28||ISR: <0.001 Sex: 0.026|
|LDL (mg/dL)||96 ± 37||117 ± 46||76 ± 29||83 ± 26||ISR: <0.001 Sex: 0.106|
|HDL (mg/dL)||43 ± 19||50 ± 15||44 ± 13||58 ± 19||ISR: 0.569 Sex: <0.001|
|TG (mg/dL)||232 ± 217||203 ± 178||164 ± 153||112 ± 43||ISR: 0.027 Sex: 0.215|
Conclusions: Hyperlipidemia during CNI immunosuppression is multifactorial and influenced by sex and ABCB1 haplotype (TTT). This finding may impact individualization strategies for post-transplant hyperlipidemia.
To cite this abstract in AMA style:Meaney C, Venuto R, Brazeau D, Consiglio J, Cooper L, Wilding G, Tornatore K. ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/abcb1-haplotypes-sex-calcineurin-inhibitors-and-lipid-profiles-post-renal-transplant/. Accessed May 22, 2019.
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