ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant
1NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY
2School of Pharmacy, Buffalo, NY
3Medicine, School of Medicine, Buffalo, NY
4University of New England College of Pharmacy, Portland, ME
5Biostatistics, School of Public Health, University at Buffalo, Buffalo, NY.
Meeting: 2015 American Transplant Congress
Abstract number: B267
Keywords: Adverse effects, Immunosuppression, Lipids, P-glycoprotein
Session Information
Session Name: Poster Session B: Translational Genetics and Proteomics in Transplantation
Session Type: Poster Session
Date: Sunday, May 3, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Purpose: Hyperlipidemia is common in renal transplant recipients (RTR) during calcineurin inhibitor (CNI) immunosuppression. P-glycoprotein (P-gp) is an efflux transporter encoded by ABCB1 that modulates lipid transport, statin response and CNI exposure with a primary variant (TTT) associated with reduced function compared to wild-type (CGC). This study evaluated ABCB1 haplotypes, sex, CNI regimen and lipid profiles among RTR.
Methods: A prospective, cross-sectional study was completed in 149 stable RTR (estimated glomerular filtration rate 51±17ml/min/1.73m2) receiving cyclosporine (CYA) and mycophenolic acid (MPA; n=82) or tacrolimus (TAC) and MPA (n=67) for ≥ 6 months. Lipid profiles were obtained after 12-hour fast. The ABCB1 single nucleotide polymorphisms (SNP): c.1236C>T (rs1128503), c.2677G>T (rs2032582), and c.3435C>T (rs1045642) were determined and haplotype associations estimated by THESIAS.
Results: Lipids are summarized (Table) by sex and CNI.
CYA+MPA (n=82) | TAC+MPA (n=67) | ||||
Lipid Parameter | Male (n=67) | Female (n=14) | Male (n=38) | Female (n=29) | P-value |
TCH (mg/dL) | 182 ± 47 | 223 ± 57 | 152 ± 48 | 163 ± 28 | ISR: <0.001 Sex: 0.026 |
LDL (mg/dL) | 96 ± 37 | 117 ± 46 | 76 ± 29 | 83 ± 26 | ISR: <0.001 Sex: 0.106 |
HDL (mg/dL) | 43 ± 19 | 50 ± 15 | 44 ± 13 | 58 ± 19 | ISR: 0.569 Sex: <0.001 |
TG (mg/dL) | 232 ± 217 | 203 ± 178 | 164 ± 153 | 112 ± 43 | ISR: 0.027 Sex: 0.215 |
Conclusions: Hyperlipidemia during CNI immunosuppression is multifactorial and influenced by sex and ABCB1 haplotype (TTT). This finding may impact individualization strategies for post-transplant hyperlipidemia.
To cite this abstract in AMA style:
Meaney C, Venuto R, Brazeau D, Consiglio J, Cooper L, Wilding G, Tornatore K. ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/abcb1-haplotypes-sex-calcineurin-inhibitors-and-lipid-profiles-post-renal-transplant/. Accessed October 15, 2024.« Back to 2015 American Transplant Congress