2019 American Transplant Congress
Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration
*Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…2019 American Transplant Congress
Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion
*Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…2019 American Transplant Congress
Transplant Provider Adherence to Cardiovascular Disease Primary Prevention Guidelines in Liver Transplant Recipients
*Purpose: Blood pressure (BP) control, aspirin, and statin use are modifiable risk factors for primary prevention of atherosclerotic cardiovascular disease (ASCVD), stroke, and heart failure…2019 American Transplant Congress
Hypoadiponectinemia is Associated with Low Handgrip Strength in Renal Transplant Recipients
*Purpose: Adiponectin was synthesized and expressed by adipocytes. However, recently it was suggested that adiponectin is also secreted and expressed by skeletal muscle. Decline of…2019 American Transplant Congress
Serum Apolipoproteins B and A1 Predict the Development of Late Post-Transplant Diabetes Mellitus in Prevalent Adult Kidney Transplant Recipients
St Michael's Hospital, University of Toronto, Toronto, ON, Canada
*Purpose: Post-transplant diabetes mellitus (PTDM) increases adverse outcomes. The risk factors for PTDM have not been fully delineated. Glucose metabolism links closely to cholesterol metabolism.…2019 American Transplant Congress
Effects of Statin Use on Cardiovascular Outcome in Patients with Renal Transplantation
*Purpose: Cardiovascular disease is the main cause of death among patients with end-stage renal disease (ESRD). Statin, HMG-CoA reductase inhibitor, is well known to significantly…2019 American Transplant Congress
Gene Expression Profiles in CD8+ T Cells in Chronic Antibody-Mediated Rejection (CAMR) of Kidney Transplantation
*Purpose: CAMR is the main cause of chronic graft injury and subsequent graft loss. Most of the studies on the subject focused their attention to…2017 American Transplant Congress
CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).
1UMB, Baltimore; 2UM, Minneapolis
Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…2017 American Transplant Congress
Evolution of Lipid Profile and Major Adverse Cardiac Events in Kidney Transplant Recipients Converted from Calcineurin Inhibitor to Everolimus: 24-Month Subanalysis from Elevate Study.
1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland
PURPOSE: Posttransplant (post-Tx) lipid abnormalities may increase risk of cardiovascular (CV) events in kidney transplant recipients (KTxR). Previous analysis from ELEVATE (NCT01114529) study confirmed that…
American Transplant Congress abstracts