Articles tagged "Lipids"

2022 American Transplant Congress
A Single-Center Cross-Sectional Analysis of Lipid Management in Kidney Transplant Recipients: Is It Time to Reassess KDIGO Guidelines?
R. Saranu¹, J. Pandav¹, M. Balusu², J. Azzi¹, M. Y. Yeung¹, M. McGrath¹, E. Abdel-Basset¹, S. Gabardi¹, A. Chandraker¹
¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
*Purpose: Cardiovascular disease remains the leading cause of mortality after kidney transplant, accounting for more than 30% of total deaths. Dyslipidemia is common following transplantation,…
2022 American Transplant Congress
Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles
J. S. Rink¹, Y. Sambandam², J. He², J. Mathew³, J. R. Leventhal⁴, C. S. Thaxton⁵
¹Department of Medicine, Division of Hematology/ Oncology, Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Department of Urology, Northwestern University, Chicago, IL
*Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…
2022 American Transplant Congress
A Nationwide, Multi-Center Survey of Lipid Management Strategies in Kidney Transplant Recipients
J. Pandav, R. Saranu, S. Muhsin, Z. Solhjou, J. Y. Choi, S. Gabardi, A. Chandraker
Renal division, Brigham and Women's Hospital, Boston, MA
*Purpose: KDIGO 2013 guidelines for the management of lipid transplant recommend the use of statins in all kidney transplant recipients (KTRs), but with weak evidence…
2020 American Transplant Congress
De Novo NAFLD Post-Liver Transplant is Defined by Altered Lipid Metabolism and Mitochondrial Dysfunction
M. Bhat¹, E. Pasini¹, M. Angeli¹, J. Allard², A. Humar¹
¹Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²Division of Gastroenterology and Hepatology, UHN, Toronto, ON, Canada
*Purpose: De Novo Non-alcoholic Fatty Liver Disease (NAFLD) affects up to 35% of liver transplant (LT) recipients transplanted for non-NAFLD indications. Non-alcoholic steatohepatitis (NASH), the…
2020 American Transplant Congress
Free Fatty Acids and Delayed Graft Function after Kidney Transplantation: A Single Center Analysis
J. Zhou¹, J. Lyu¹, X. Yu¹, C. Wu², J. Chen¹
¹The First Affiliated Hospital Kidney Disease Center, College of Medicine, Zhejiang University, Hangzhou, China, ²Global Health Research Center, Duke Kunshan University, Kunshan, China
*Purpose: Delayed graft function (DGF) is one of the most common obstacles of donation after circulatory death (DCD) kidney transplantation. Serum free fatty acids (FFAs)…
2020 American Transplant Congress
Undernutrition and Hypoleptinemia Modulate Cytomegalovirus Infection
E. David¹, M. Zhu², W. Parker², N. MacIver¹, A. D. Kirk², E. T. Chambers¹
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Cytomegalovirus (CMV) viremia/infection remains a significant cause of morbidity in transplantation, especially in the undernourished population. Undernutrition and hypoleptinemia have been implicated in other…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration
Y. Xiong¹, W. Piao¹, C. Brinkman¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁵, S. Schwab⁶, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's hospital, Boston, MD, ⁵U.Minnesota, Minneapolis, MN, ⁶NYU, NY, NY
*Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…
2019 American Transplant Congress
S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁶, S. Schwab⁷, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's, Boston, MA, ⁵U.Minnesota, Minneapolis, MN, ⁶U.Minnesota, Minneapolis, MD, ⁷NYU, NY, NY
*Purpose: T cells utilize S1PR1 to traffic from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether T cell S1PR1 and S1PR4 regulate…
2019 American Transplant Congress
Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion
S. Raigani¹, N. Karimian², V. Huang², S. Geerts², S. Nagpal², K. Uygun¹, M. Yarmush¹, H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Center for Engineering in Medicine, Shriners Childrens Hospital, Boston, MA
*Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…
2019 American Transplant Congress
Transplant Provider Adherence to Cardiovascular Disease Primary Prevention Guidelines in Liver Transplant Recipients
M. Kosirog¹, P. T. Campbell¹, S. Montag², S. Connolly¹, A. Daud³, A. Das¹, S. Pine¹, D. Finn³, J. Levitsky¹, J. L. Holl⁴, D. M. Lloyd-Jones⁵, L. B. VanWagner⁶
¹Division of GI and Hepatology, Department of Medicine, Northwestern Medicine, Chicago, IL, ²Department of Preventative Medicine, Northwestern Medicine, Chicago, IL, ³Center for Healthcare Studies, Northwestern Medicine, Chicago, IL, ⁴Department of Pediatrics and Center for Healthcare Studies, Northwestern Medicine, Chicago, IL, ⁵Department of Preventive Medicine and Division of Cardiology, Department of Medicine, Northwestern Medicine, Chicago, IL, ⁶Division of GI and Hepatology, Department of Medicine and Department of Preventive Medicine, Northwestern Medicine, Chicago, IL
*Purpose: Blood pressure (BP) control, aspirin, and statin use are modifiable risk factors for primary prevention of atherosclerotic cardiovascular disease (ASCVD), stroke, and heart failure…