2017 American Transplant Congress
CD4 T Cell Migration Across Lymphatic Endothelium Is Enhanced by Sphingosine 1-Phosphate (S1P) and Differentially Regulated by S1P Receptors (S1PR).
1UMB, Baltimore; 2UM, Minneapolis
Introduction: S1PR1 drives T cells to migrate from thymus to blood, and from lymph node (LN) to efferent lymphatics. Whether S1PR1 or other S!PRs regulate…2017 American Transplant Congress
Evolution of Lipid Profile and Major Adverse Cardiac Events in Kidney Transplant Recipients Converted from Calcineurin Inhibitor to Everolimus: 24-Month Subanalysis from Elevate Study.
1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland
PURPOSE: Posttransplant (post-Tx) lipid abnormalities may increase risk of cardiovascular (CV) events in kidney transplant recipients (KTxR). Previous analysis from ELEVATE (NCT01114529) study confirmed that…2017 American Transplant Congress
Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.
Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…2017 American Transplant Congress
Lipid Abnormalities and Cardiovascular Events After Early Conversion to Everolimus in Kidney Transplant Recipients with Pretransplant Diabetes: 24-Month Analysis from Elevate Study.
1ELEVATE Study Group, Berlin, Germany; 2Novartis Pharma AG, Basel, Switzerland
PURPOSE: Pretransplant (preTx) diabetes is an independent risk factor for cardiovascular (CV) events, and posttransplant (post-Tx) hyperlipidemia further increases CV risk. To analyze the influence…2016 American Transplant Congress
Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.
1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.
S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…2016 American Transplant Congress
Influence of Lipid Levels on Cardiovascular Events After Early Conversion from Calcineurin Inhibitor to Everolimus: 24 M Analysis of the ELEVATE Study.
Background: Immunosuppressive therapies are probably the most important cause of hyperlipidemia post-renal transplantation (RTx). Lipid abnormalities represent important biomarkers for cardiovascular (CV) risk. Here, we…2016 American Transplant Congress
Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.
Introduction: EVNP has the potential to repair deceased donor renal IRI. We hypothesize that EVNP may attenuate renal IRI via alteration of lipid metabolism.Methods: Eight…2016 American Transplant Congress
Higher Pre-Transplant HDL Levels Are Associated with Decreased Acute Rejection Following Kidney Transplant.
Purpose: Dyslipidemia is a common comorbidity in patients on the transplant waitlist and post-transplant, and hyperlipidemia has been associated with more robust immune response, possibly…2016 American Transplant Congress
CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.
PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…2015 American Transplant Congress
ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant
Purpose: Hyperlipidemia is common in renal transplant recipients (RTR) during calcineurin inhibitor (CNI) immunosuppression. P-glycoprotein (P-gp) is an efflux transporter encoded by ABCB1 that modulates…
American Transplant Congress abstracts