2015 American Transplant Congress » Poster Session B: Translational Genetics and Proteomics in Transplantation

Date: Sunday, May 3, 2015

Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Session Type: Poster Session

Meeting: 2015 American Transplant Congress

5:30pm-6:30pm: ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant

C. Meaney,^1,2 R. Venuto,³ D. Brazeau,⁴ J. Consiglio,⁵ L. Cooper,¹ G. Wilding,⁵ K. Tornatore.^1,2,3

5:30pm-6:30pm: Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis

A. Jaramillo,¹ R. Vaidya,² M. Pando,³ S. Gaitonde.⁴

5:30pm-6:30pm: Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection

S. Shimizu, Y. Tanaka, H. Tazawa, S. Verma, H. Ohdan.

5:30pm-6:30pm: Are DQA Antibodies Real?

J. Jones, D. Lucas, M. Leffell, A. Zachary.

5:30pm-6:30pm: BK Virus-Specific Polyfunctional CD8+ T Cells Predicts Successful Control of BK Viremia After Kidney Transplantation

J. Schaenman,¹ Y. Korin,² T. Sidwell,² F. Kandarian,² N. Harre,² P.-T. Pham,³ S. Bunnapradist,³ G. Danovitch,³ J. Veale,⁴ H. Gritsch,⁴ E. Reed.²

5:30pm-6:30pm: Clinical Significance of Estimated DSA MFI Values at 1,000 C1q MFI for Differentiation Between Harmful and Harmless DSA

K. Horimi,¹ T. Akaza,² K. Kuroki,² S. Sakamoto,² Y. Matsuoka,¹ Y. Watarai,² S. Narumi,² A. Katayama,³ K. Uchida,¹ T. Kobayashi.⁴

5:30pm-6:30pm: DNA Methylation Classifier Associates With Long-Term Graft Function Post-Kidney Transplantation

J. Suh,¹ D. Maluf, K. Archer,² T. Lee,¹ L. Gallon,³ V. Mas.¹

5:30pm-6:30pm: Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins

S. Daga,^1,2 D. Lowe,⁶ R. Buchli,⁵ J. Collard,⁵ A. Mulder,⁸ C. McMurtrey,^4,5 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^4,5 F. Claas,⁸ D. Briggs,³ D. Zehnder,^1,2 D. Mitchell,¹ R. Higgins.^1,2

5:30pm-6:30pm: Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients

C. Dorr,¹ B. Wu,² W. Guan,² A. Muthusamy,¹ K. Sanghavi,³ P. Jacobson,³ W. Oetting,³ D. Schladt,¹ R. Remmel,³ J. Maltzman,⁵ A. Matas,⁴ For DeKAF Genomics Investigators,¹ A. Israni.¹

5:30pm-6:30pm: Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants

T. Srinivas, P. Baliga, K. Chavin, M. Gebrezhiaber, L. Egede, D. Taber.

5:30pm-6:30pm: First Dose Tacrolimus Level Is Better Than CYP3A5 Genotyping in Prediction of Target Tacrolimus Dose

N. Townamchai,¹ W. Chancharoenthana,¹ S. Wattanatorn,¹ S. Vadcharavivad,² P. Chariyavilaskul,³ A. Leelahavanichkul,⁴ Y. Avihingsanon,¹ K. Praditpornsilpa.¹

5:30pm-6:30pm: Gene Expression of Kidney Biopsies Reveals Common Mechanisms of Rejection and a Cluster of Co-Expressed Genes Predictive of Long-term Outcomes

B. Modena,¹ S. Kurian,¹ J. Friedewald,² F. Harrison,¹ T. Gelbart,¹ S. Head,¹ M. Abecassis,² D. Salomon.¹

5:30pm-6:30pm: Genetic Diversity Epstein-Barr Virus Latent Gene EBNA-1 Among Transplant Patients and Patients With Infectious Mononucleosis

K. Sullivan,¹ S. Isabel,¹ E. Maria,¹ P. Tara,¹ Y. Simon,¹ K. Nasser,¹ N. Vicky,² A. Upton.¹

5:30pm-6:30pm: HLA-C, KIR Genotypes and KIR Genotype/HLA –C Ligand Combination in Prediction of Early Acute Rejection After Liver Transplantation

K. Park,¹ J. Ryu,¹ H. Park,³ Y. Kim,² E.-J. Oh.²

5:30pm-6:30pm: Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data

B. Keating,¹ Y. Li,¹ T. Guettouche,² K. Olthoff,¹ A. Shaked.¹

5:30pm-6:30pm: Improving the Predictive Value of the Virtual Crossmatch: Is the C1Q Assay Needed?

A. Colovai,¹ C. Savchik,¹ P. Masiakos,¹ S. Calp-Inal,² L. Kayler,³ E. Akalin.²

5:30pm-6:30pm: Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients

T. Alford,¹ R. Page,¹ J. Lindenfeld,² C. Aquilante.¹

5:30pm-6:30pm: Interrogation of Plasma Cell-Rich Acute Rejection in Human Kidney Allografts by Whole Transcriptome Sequencing

L. Mesnard, F. Campagne, H. Yang, D. Dadhania, J. Lee, S. Seshan, M. Suthanthiran, T. Muthukumar.

5:30pm-6:30pm: Longitudinal Multi-Omic Profiling of Genes and Pathways Underlying Cardiac Allograft Rejection

B. Piening,¹ Y. Li,² A. Shaked,² B. Keating,² M. Snyder.¹

5:30pm-6:30pm: Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation

S. Daga,^1,2 D. Lowe,⁶ R. Buchli,³ J. Collard,³ A. Mulder,⁸ C. McMurtrey,^3,4 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^3,4 F. Claas,⁸ D. Briggs,⁵ D. Zehnder,^1,2 D. Mithcell,¹ R. Higgins.^1,2

5:30pm-6:30pm: Molecular Testing for Microcirculation Injury Enhances the Assessment of Antibody-Mediated Rejection in Human Cardiac Allograft Biopsies

B. Afzali,¹ E. Chapman,¹ B. Adam,¹ F. Riesgo Gil,² D. Kim,² L. Hidalgo,¹ P. Campbell,¹ B. Sis,¹ M. Mengel.¹

5:30pm-6:30pm: Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support

A. Schenk,¹ J. Fallon,¹ M. Farrell,¹ R. Halter,² J. Yun.³

5:30pm-6:30pm: Perturbation of Polyomavirus Nephropathy-Specific Gene Expression in Kidney Allografts

T. Sigdel,¹ O. Bestard,^1,2 N. Salomonis,³ S.-C. Hsieh,¹ M. Naesens,⁴ J. Torras,² T. Tran,¹ S. Roedder,¹ M. Sarwal.¹

5:30pm-6:30pm: Pharmacogenetic Variation in Renal Calcineurin Inhibitor (CNI) Metabolism and the Response of Allograft-Derived Proximal Tubule Cells

N. Knops,^1,2 L. van den Heuvel,² R. Masereeuw,³ H. de Loor,⁴ E. Levtchenko,^1,2 D. Kuypers.^5,4

5:30pm-6:30pm: Pharmacogenomic Predictors of Acute Rejection in Kidney Transplant Recipients Identified Using a DNA Biobank Linked to Electronic Medical Records

K. Birdwell,¹ D. Velez-Edwards,² G. Vranic,⁵ J. Denny,^1,3 L. Choi,⁴ T. Ikizler,¹ D. Haas.¹

5:30pm-6:30pm: Potential Urine Protein Biomarkers for Kidney Transplantation Dysfunction Through Quantitative Proteomics

T. Sigdel,¹ N. Salomonis,² C. Nicora,³ J. He,³ W.-J. Qian,³ D. Camp,³ M. Sarwal.¹

5:30pm-6:30pm: Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)

R. Catar,¹ C. Luecht,¹ M. Simon,¹ A. Philippe,¹ A. Kusch,¹ M. Szczepek,² P. Hildebrand,² P. Scheerer,² D. Dragun.¹

5:30pm-6:30pm: Proteomic Study Identified a Distinct Panel of Protein Expression in the ATP-Competitive MTOR Kinase Inhibitor Conditioned Dendritic Cells Compared to Rapamycin

T. Ma,¹ Y. Pei,¹ Y. Han,² R. Tao.¹

5:30pm-6:30pm: Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)

A. Israni,¹ C. Dorr,¹ M. Miller,² D. Schladt,¹ K. Sanghavi,³ A. Muthusamy,¹ R. Remmel,³ W. Guan,⁴ B. Wu,⁴ W. Oetting,³ P. Jacobson,³ A. Matas,⁵ For DeKAF Genomics & GEN03 Investigators.¹

5:30pm-6:30pm: Structural and Functional Basis for Non-HLA Antibody Mediated AT1R Activation

D. Dragun, D. Postpieszala, N. Zhu, R. Catar, A. Philippe.

5:30pm-6:30pm: The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients

D. Taber, T. Srinivas, N. Pilch, M. Gebregziabher, L. Egede, P. Baliga, K. Chavin.

5:30pm-6:30pm: The Design and Implementation of a Genome-Wide Genotyping Array Tailored for Transplantation

B. Keating,¹ A. Israni,² Y. Li,¹ M. Holmes,¹ K. Birdwell,³ F. Asselbergs,⁴ A. Shaked.¹

5:30pm-6:30pm: The Use of Systems Biology to Identify Mitochondrial Dysfunction and Metabolic Dysregulation as Targets for Intervention in the Brain Dead Organ Donor

M. Akhtar, L. Lo Faro, R. Robelledo, M. Kaisar, H. Huang, H. Leuvenink, P. Friend, S. Fuggle, C. Pugh, R. Ploeg.

5:30pm-6:30pm: Urinary Cell-Free DNA Is a Sensitive Marker of Early Renal Transplant Injury

T. Sigdel, T. Tran, S.-C. Hsieh, M. Sarwal.

5:30pm-6:30pm: Use of RNA Sequencing for Discovery of Markers of Accommodation in Surveillance Biopsies from Recipients of an ABO-Incompatible Renal Transplant

A. McLean,² K. Dominy,¹ A. Sosinsky,¹ M. Mueller,¹ J. Galliford,² T. Cook,^1,2 C. Roufosse.^1,2

5:30pm-6:30pm: Validation of a Blood and Biopsy Gene Expression-Based Molecular Diagnostics for Subclinical Acute Rejection: Comparing DNA Microarrays Vs. Next-Generation RNA Sequencing

S. Kurian,¹ J. Friedewald,² F. Harrison,¹ T. Gelbart,¹ S. Head,¹ P. Ordoukhanian,¹ M. Abecassis,² D. Salomon.¹

5:30pm-6:30pm: Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study

P. Jacobson,¹ M. Miller,² D. Schladt,³ A. Israni,³ K. Sanghavi,¹ C. Dorr,³ R. Remmel,¹ W. Guan,⁴ A. Matas,⁵ W. Oetting.¹

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