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A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.

R. Danger,1 M. Chesneau,1 C. Paul,1 P. Guérif,1 M. Durand,1 K. Newell,2 S. Kanaparthi,3 L. Turka,4 J.-P. Soulillou,1 R. Houlgatte,5 M. Giral,1,6 G. Ramstein,7 S. Brouard.1,6

1Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université
de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France
2Department of Surgery, Emory University, Atlanta, GA
3Immune Tolerance Network, Bethesda, MD
4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
5INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France
6CIC Biotherapy, CHU Nantes, Nantes, France
7LINA DUKe, UMR 6241, Université
de Nantes, Ecole des Mines de Nantes &
CNRS, Nantes, France

Meeting: 2017 American Transplant Congress

Abstract number: C280

Keywords: Gene expression, Graft survival, Tolerance

Session Information

Date: Monday, May 1, 2017

Session Name: Poster Session C: Tolerance/Immune Regulation

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Related Abstracts
  • Operational Tolerance in Intestinal Transplantation: A Proven Possibility.
  • Operational Tolerance in Kidney Transplantation: Results of a Europe-Wide Survey

New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and ascertaining the best combination and appropriate dosages of drugs. Based on a 20-genes signature from a microarray meta-analysis, with 46 operationally tolerant patients and 266 renal transplanted recipients with stable function, we applied the sparse Bolasso methodology to identify a minimal and robust combination of six genes and two demographic parameters as significantly associated with operational tolerance. This composite score of operational tolerance (cSoT) discriminates operationally tolerant patients with an AUC of 0.97 (95% CI= 0.94–1.00). The cSoT is not influenced by immunosuppressive treatment, center of origin, donor type, or post-transplant lymphoproliferative disorder history of patients. The cSoT is associated with de novo anti-HLA antibodies (p = 0.0011) and tolerance loss (p = 0.026). It was validated by quantitative PCR (AUC =0.84, 95% CI =0.65–1.00) and demonstrated specificity toward a model of tolerance induction. This score would allow clinicians to highlight immune tolerance status of recipients and may improve follow-up of patients, thus paving the way for individual therapy.

CITATION INFORMATION: Danger R, Chesneau M, Paul C, Guérif P, Durand M, Newell K, Kanaparthi S, Turka L, Soulillou J.-P, Houlgatte R, Giral M, Ramstein G, Brouard S. A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Danger R, Chesneau M, Paul C, Guérif P, Durand M, Newell K, Kanaparthi S, Turka L, Soulillou J-P, Houlgatte R, Giral M, Ramstein G, Brouard S. A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/a-composite-score-associated-with-spontaneous-operational-tolerance-in-kidney-transplant-recipients/. Accessed March 4, 2021.

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