Articles tagged "Gene expression"

2019 American Transplant Congress
Characterizing the Dominant Phenotype in Kidney Transplant Biopsies: Improving the Prediction of Risk by a Global View of Rejection, Injury, and Atrophy-Fibrosis
P. F. Halloran and The INTERCOMEX Investigators¹, J. Reeve²
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Interpreting kidney transplant biopsies by histology or molecules involves assigning scores for separate pathologic categories: rejection, acute injury (molecules only), and chronic parenchymal loss…
2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…
2019 American Transplant Congress
Dissecting The Role Of Donor Acute Kidney Injury On Molecular Responses Post-transplantation
S. Bontha¹, D. Maluf¹, E. Akalin², L. Gallon³, J. Eason⁴, V. Mas⁵
¹UTHSC, Memphis, TN, ²Albert Einstein Medical College, Bronx, NY, ³Northwestern University, Chicago, IL, ⁴Director of Transplantation, Memphis, TN, ⁵Director of Transplant Research, Memphis, TN
*Purpose: In the current scenario of shortage of donor organs, kidneys with AKI are being used and outcome research reports show that the outcomes could…
2019 American Transplant Congress
Correlation between Gene Expression and Cardiac Function in Ex Vivo Perfused Porcine Hearts
S. Rotich, N. Herbers, S. Hatami, J. Nagendran, M. Mengel, D. Freed, B. Adam
University of Alberta, Edmonton, AB, Canada
*Purpose: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is limited by a shortage of suitable donor organs. Ex vivo heart…
2019 American Transplant Congress
The Changing Face of T Cell-Mediated Rejection
A. Perkowska-Ptasinska and INTERCOMEX investigators¹, P. F. Halloran²
¹Medical University of Warsaw, Warsaw, Poland, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: We studied how the problem of TCMR in indication biopsies was changing with time by exploring features of 138 biopsies with molecular TCMR in…
2019 American Transplant Congress
Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients
H. Hwang¹, J. Seo¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea, Republic of
*Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
2019 American Transplant Congress
Relationship between HLA-DPB1 Gene Expression in Pre-Implantation Kidney Biopsies, Rs9277534 Polymorphism, and Late Graft Function
K. L. Mine¹, T. B. Mourão¹, C. Felipe², G. F. Rampim¹, J. O. Medina-Pestana², H. Tedesco-Silva², M. Gerbase-DeLima¹
¹Immunogenetics Institute, Associação Fundo de Incentivo a Pesquisa - AFIP, Sao Paulo, SP, Brazil, ²Hospital do Rim, Sao Paulo, SP, Brazil
*Purpose: A previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of adult deceased donors (D) showed association between high class II HLA…
2019 American Transplant Congress
Comprehensive and Combined Transcriptomic and Proteomic Analysis Reveals Key Factors Underlying Ischemia-Reperfusion Injury in Human Liver Transplantation
S. Huang, X. He, C. Sun, Z. Guo, W. Ju, Z. Zhu, Q. Zhao, G. Chen
Organ Transplant Center, the First Affiliated Hospital of SYSU, Guangzhou, China
*Purpose: Ischemia-reperfusion injury (IRI) is a major challenge in liver resection and liver transplantation surgery. Hepatic IRI can seriously impair liver function and even cause…
2019 American Transplant Congress
Urinary Cell mRNA Sequencing Profiles of Kidney Allograft Recipients Mirror Intragraft Events and Demonstrate Enrichment for Immune Cells
M. Lubetzky¹, A. Verma², H. Yang¹, T. Muthukumar¹, S. Salvatore¹, J. Lee¹, D. Dadhania¹, S. Seshan¹, F. Mueller¹, O. Elemento², M. Suthanthiran¹
¹Division of Nephrology, Weill Cornell, New York, NY, ²Institute for Computational Biomedicine, Weill Cornell, New York, NY
*Purpose: Urinary cell mRNA profiling to interrogate kidney allograft status is based on the premise that the allograft can function as an in-vivo flow cytometer…
2019 American Transplant Congress
Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis
D. Rychkov¹, T. Sigdel², J. Liberto², M. Sarwal², M. Sirota³
¹ICHS, Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, UCSF, San Francisco, CA, ³ICHS, UCSF, San Francisco, CA
*Purpose: Histologically stable allografts have been shown to have molecular inflammation by prior gene expression studies. Nevertheless, there are no methodologies in place to sub-group…