BK Polyoma Virus and Malignancy: Cause or Co-Incidence?
Henry Ford Transplant Institute, Detroit, MI
Meeting: 2017 American Transplant Congress
Abstract number: A218
Keywords: Induction therapy, Malignancy, Polyma virus, Post-transplant malignancy
Session Information
Session Name: Poster Session A: Kidney: Polyoma
Session Type: Poster Session
Date: Saturday, April 29, 2017
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall D1
Background
The WHO agency for cancer research has classified BKV as "possibly carcinogenic".The etiological role of BKV in human cancer, however,remains controversial.We present 5 cases of malignancies in Solid Organ Transplant recipients in association with BKV
Methods
The clinical characteristics and histology/immunohistochemistry(IHC) of tumors was studied by a chart review of 5 SOTR with renourinary tract tumors and +SV40 IHC and/or BK viremia
Results
| Age at diagnosis | Organ/Transplant
Year |
Year of diagnosis of BKV (Yrs posttransplant) | Year of diagnosis of cancer (Yrs posttransplant) | Location/Invasion | SV40 | Histology | |
| 1 | 47 M | Heart 1998
Kidney 2011 |
2012(14) | 2015(17) | Bladder/pT1 | + | Adenocarcinoma,micro papillary variant |
| 2 | 57 M | Kidney 2003 | 2011(8) | 2016(13) | Transplant kidney/pT3a | + | Poorly differentiated carcinoma |
| 3 | 58 M | Lung 2008 | 2015(7) | Bladder/pT2 | + | Urothelial: Small tubular pattern, plasmacytoid | |
| 4 | 72 M | Heart 1993 | 2007 (14)
2016(23) |
Bladder/pT1 at diagnosis
LN/pXM1 |
+(LN) | Micropapillary variant GATA-3/CK7+ | |
| 5 | 47 M | SPK 2008 | 2011(3) | 2016(8) | Bladder
Transplant ureter/pT2 |
Ureter urothelial ca, high grade
Bladder urothelial ca in situ |
All patients were male with mean age of 56.6 years and 2 were dual organ transplants.3 SOTRs received induction with ATG. The mean time to diagnosis of cancer from transplant was 11.8 years. All Renal transplant recipients had BKV for a mean duration of 4.3 years prior to diagnosis of cancer.4 tumors had positive SV40, it is still pending in one case(5).The occurrence of urothelial cancer in transplant ureter along with bladder cancer in this patient, with tumor genotype revealing recipient tissue rather than donor, in the presence of BKV, points towards the possibility of + SV40 in the tissue.Other interesting findings are SV40+ in a lymph node metastasis(4) and the SV40+ tumor in allograft nephrectomy tissue 2 years after the allograft failed(3)
Conclusion
While the potential oncogenic role of BKV is unclear, the increasing no. of reported renourinary tract tumors in patients with BKV, and the long latent period after transplant, warrant increased vigilance for early detection of cancers in patients with persistent BKV particularly in highly immunocompromised patients (dual organ transplants , ATG induction).
CITATION INFORMATION: Prashar R, Shah A, Stewart D, Williamson S, Patel A. BK Polyoma Virus and Malignancy: Cause or Co-Incidence? Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Prashar R, Shah A, Stewart D, Williamson S, Patel A. BK Polyoma Virus and Malignancy: Cause or Co-Incidence? [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/bk-polyoma-virus-and-malignancy-cause-or-co-incidence/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress