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Articles tagged "Xenotransplantation"

  • 2017 American Transplant Congress

    CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.

    S. Kim, L. Higginbotham, D. Mathews, C. Breeden, A. Stephenson, C. Larsen, M. Ford, J. Tector, A. Adams.

    Emory Transplant Center, Emory University, Atlanta, GA; University of Alabama Birmingham, Birmingham, AL

    Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…
  • 2017 American Transplant Congress

    CD4+/CD8+ T Cell Ratio as a Predictive Marker for Early Graft Failure in Pig to Non-Human Primate Islet Xenotransplantation with Immunosuppression.

    S. Choi,1,3,4 H.-J. Kim,1,2,3,4 I.-H. Yoon,1,2 J.-S. Kim,1,2,6 S.-J. Kang,1,2,3,4 H.-Y. Nam,1,2 B.-H. Min,1 J.-S. Shin,1,6 J.-M. Kim,1,6 Y.-H. Kim,1,5 W.-W. Lee,1,2,3,4 C.-G. Park.1,2,3,4,6

    1Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; 3Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; 4Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; 5Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea; 6Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea

    Background: Outstanding results from nonhuman primate study put islet xenotransplantation with immunosuppression closer to the clinical application. To establish successful immune suppressive protocols, immune monitoring…
  • 2017 American Transplant Congress

    CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.

    S. Kim,1 L. Higginbotham,1 D. Mathews,1 C. Breeden,1 A. Stephenson,1 C. Larsen,1 M. Ford,1 J. Tector,2 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2University of Alabama Birmingham, Birmingham, AL

    Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…
  • 2017 American Transplant Congress

    Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.

    Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY

    Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
  • 2016 American Transplant Congress

    In Vivo and In Vitro Characterization of 1.5 mm Ba2+-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.

    M. Bochenek,1 J. McGarrigle,1 J. Mendoza-Elias,1 E. Marchese,1 M. Nourmohammadzadeh,1 Y. Wang,1 A. Khan,1 M. Omami,1 C.-C. Yeh,1 I. Lacik,2 B. Strand,3 J. Oberholzer.1

    1Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; 2Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); 3Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.

    Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
  • 2016 American Transplant Congress

    Establishment of SCID Pigs Cell Lines to Prevent Immunodeficiency Using RGEN System.

    D.-H. Kim,1 J.-S. Ahn,1 S. Hwang,2 J.-W. Lee.1

    1Functional Genomics Reaserch Center, KRIBB, Daejeon, Korea; 2Animal Biotechnology Division, RDA, Wanju-gun, Jeollabuk-do, Korea.

    Severe immune disorder is the biggest problem in xenotransplantation. To overcome the the problem, producing severe combined immune deficiency (SCID) pigs which lack T cell…
  • 2016 American Transplant Congress

    The Impact of Sequential Gene Modifications on Cardiac Xenograft Survival.

    K. Horvath,1 A. Singh,1 J. Chan,1 M. Thomas,2 B. Lewis,2 D. Ayares,3 P. Corcoran,1 M. Mohiuddin.1

    1CSRP, NHLBI/NIH, Bethesda, MD; 2DVR / ORS, NIH, Bethesda, MD; 3Revivicor, Inc, Blacksburg, VA.

    Introduction: One of the major advances in xenotransplantation is the ability to modify donor pig genetics. Using rapidly evolving techniques of pig cloning and gene…
  • 2016 American Transplant Congress

    Inclusion of Human Tissue Factor Pathway Inhibitor or Thrombomodulin Transgenes Attenuates Critical Consumptive Thrombocytopenia in Cardiac Xenotransplantation.

    J. Chan,1 A. Singh,1 P. Corcoran,1 M. Thomas III,2 B. Lewis,2 D. Ayares,3 K. Horvath,1 M. Mohiuddin.1

    1Cardiothoracic Surgery Research Program/National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; 2Division of Veterinary Resources, National Institutes of Health, Bethesda, MD; 3Revivicor Inc., Blacksburg, VA.

    ObjectiveA major obstacle in the success of cardiac xenotransplantation has been the development of significant consumptive thrombocytopenia, frequently limiting recipient survival. Advances in genetic engineering…
  • 2016 American Transplant Congress

    Costimulation Blockade by Anti CD40 Antibody Prevents Humoral and Cellular Rejection of Heterotopic Pig Cardiac Xenograft.

    A. Singh,1 J. Chan,1 P. Corcoran,1 B. Lewis,2 M. Thomas,2 D. Ayares,3 K. Horvath,1 M. Mohiuddin.1

    1CSRP/NHLBI, NIH, Bethesda, MD; 2DVR/ORS, NIH, Bethesda, MD; 3Revivicor Inc., Blacksburg, VA.

    BackgroundXenotransplantation (XTx) involves the participation of innate immune system with natural antibody producing B cells, NK cells, macrophages and complement as well as adaptive immune…
  • 2016 American Transplant Congress

    Late Renal Xenograft Failure Is Antibody-Mediated: Description of the Longest-Reported Survival in Pig-to-Primate Renal Xenotransplantation.

    L. Higginbotham,1 S. Kim,1 D. Mathews,1 A. Stephenson,1 C. Breeden,1 C. Larsen,1 M. Ford,1 K. Newell,1 A. Tector,2 A. Adams.1

    1Emory Transplant Center, Emory University Hospital, Atlanta, GA; 2Indiana University School of Medicine, Indianapolis, IN.

    Introduction. Xenotransplantation has the potential to alleviate the organ supply shortage, yet pig-to-primate renal xenotransplant has met limited success due to natural preformed anti-pig antibody.…
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