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American Transplant Congress abstracts

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Articles tagged "Xenotransplantation"

  • 2017 American Transplant Congress

    Autologous Expanded Tregs and Porcine Hematopoietic Cells to Prolong Xenogeneic Pig Skin Graft Acceptance in Baboons.

    J. Stern,1 S. Kofman,1 P. Alonso-Guallart,1 E. Berglund,1 M. Danton,1 J. Weiner,1 D. Ayares,2 R. Hawley,1 K. Yamada,1 D. Sachs,1 M. Sykes,1 A. Griesemer.1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY; 2Revivicor, Blacksburg, VA

    Background: Mixed chimerism (MC) has been shown to induce tolerance to allogeneic organs and has shown promise for application to xenotransplants, although long-term tolerance has…
  • 2017 American Transplant Congress

    Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.

    C. Laird,1 B. French,1 L. Burdorf,1 X. Cheng,1 W. Fogler,2 J. Magnani,2 C. Phelps,3 D. Ayares,3 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland SOM, Baltimore; 2GlycoMimetics, Inc, Rockville; 3Revivicor, Inc, Blacksburg

    Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…
  • 2017 American Transplant Congress

    Addition of hEPCR.hCD55.hTFPI.hCD47 Modulates Multi-Lineage Cell Sequestration and Coagulation Activation by GalTKO.hCD46 Transgenic Pig Livers Perfused Ex Vivo with Human Blood.

    A. Cimeno,1 L. Burdorf,1 D. Parsell,1 C. Phelps,2 D. Ayares,2 A. Azimzadeh,1 R. Pierson III,1 R. Barth,1 J. LaMattina.1

    1Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD; 2Revivicor, Inc., Blacksburg, VA

    PurposeThe sequestration of multiple hematopoietic cell lineages and inappropriate coagulation cascade activation is associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate…
  • 2017 American Transplant Congress

    Coagulation Pathway Perturbations Associated with Pig-to-Baboon Lung Xenotransplantation.

    S. Sendil, B. French, O. Siddiqui, D. Parsell, C. Laird, A. Cimeno, S. Dahi, L. Burdorf, A. Azimzadeh, R. Pierson III.

    Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD

    Aim Dysregulation of coagulation is associated with graft failure in multiple xenotransplantation models. This study describes thromboelastographic profiles in baboon recipients of a genetically engineered…
  • 2017 American Transplant Congress

    Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.

    J. Shah, M. Patel, N. Elias, I. Rosales, N. Navarro-Alvarez, M. Hertl, A. Cosimi, R. Colvin, J. Markmann, D. Sachs, P. Vagefi.

    Massachusetts General Hospital, Boston, MA

    Background: Since the first attempt in 1968, survival following pig-to-baboon liver xenotransplantation (LXT) has been limited to <9-days due to a lethal coagulopathy. To improve…
  • 2017 American Transplant Congress

    Lack of Xenograft Recipient Monitoring by Telemetry Lets Infection Go Unchecked and Trigger Coagulopathy.

    M. Mohiuddin,1 A. Singh,1 J. Chan,1 P. Corcoran,1 B. Lewis,2 M. Thomas,2 D. Ayares,3 K. Horvath.1

    1NHLBI / NIH, Bethesda; 2ORS / NIH, Bethesda; 3Revivicor, Inc, Blackburgh

    Introduction: A major complication of a xenograft is the potential for coagulation disorder characterized by thrombocytopenia and bleeding. This complication was rarely seen in our…
  • 2017 American Transplant Congress

    Orthotopic Liver Transplantation of Xenogeneic Livers Repopulated with Autologous Hepatocytes: Proof of Normal Function and Consistent Survival.

    G. Oldani, S. Lacotte, L. Orci, V. Delaune, C. Toso.

    Geneva University Hospitals, Geneva, Switzerland

    BackgroundGeneration of transplantable patient-like organs in pigs will solve the problem of organ shortage and potentially extend the indications for liver transplantation. However, the efficacy…
  • 2017 American Transplant Congress

    The Role of Anti-Neu5Gc IgM in Xenograft Antibody Mediated Rejection.

    W. Hassanein,1 G. Braileanu,1 L. Burdorf,1 W. Sun,1 B. French,1 C. Laird,1 S. Sendil,1 C. Ahn,3 D. Ayares,2 R. Pierson III,1 A. Azimzadeh.1

    1University of Maryland School of Medcine, Baltimore, MD; 2Revivicor, Blacksburg, VA; 3Seoul National University Hospital, Seoul, Korea

    Background:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Here, we measured anti-Neu5Gc-IgM antibody titers in…
  • 2017 American Transplant Congress

    Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.

    A. Singh,1 S. Agbor-Enoh,2 J. Chan,1 S. Groham,2 P. Corcoran,1 B. Lewis,3 M. Thomas,3 D. Ayares,4 K. Horvath,1 H. Valantine,2 M. Mohiuddin.1

    1CSRP, NHLBI/NIH, Bethesda, MD; 2LTG, NHLBI/NIH, Bethesda, MD; 3ORS/NIH, Bethesda, MD; 4Revivicor, Inc, Blacksburg, VA

    Detection of early graft rejection (EGR) is a great deal in the field of transplantation (Tx). A number of biomarkers have been used to determine…
  • 2017 American Transplant Congress

    Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonald,1 H. Xu,1 R. Smith,3 A. Dorling,3 A. Kirk,1 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas'NHS Foundation Trust, London, United Kingdom; 3MRC Centre for Transplantation, King's College, London, United Kingdom

    Introduction: Early activation of coagulation and complement are important factors in the initiation of instant blood mediated inflammation (IBMIR) in xenoislet models. Two novel 'cytotopic'…
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