ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2016 American Transplant Congress

    Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.

    K. Nakamura,1 M. Zhang,2 B. Ke,1 S. Kageyama,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.

    Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, plays a key role in inflammation responses and stress resistance. Although SIRT1 may regulate innate activation…
  • 2016 American Transplant Congress

    Differential Effect of Delayed Graft Function (DGF) on Kidney Transplant Outcomes: When Does DGF Not Make a Difference?

    M. Khan,1 H. El-Hennawy,1 A. Farney,1 J. Rogers,1 G. Orlando,1 A. Reeves-Daniel,2 A. Palanisamy,2 M. Gautreaux,3 S. Iskandar,3 W. Doares,4 S. Kaczmorski,4 R. Stratta.1

    1Surgery, Wake Forest, Winston-Salem, NC; 2Internal Medicine, Wake Forest, Winston-Salem, NC; 3Pathology, Wake Forest, Winston-Salem, NC; 4Pharmacy, Wake Forest, Winston-Salem, NC.

    Delayed graft function (DGF), defined as need for dialysis in 1st week following kidney transplant (KT), is an early surrogate marker of organ quality and…
  • 2015 American Transplant Congress

    Predicting Renal Recovery After Liver Transplant With Severe Pretransplant Sub-Acute Kidney Injury: The Impact of Warm Ischemic Time

    H. Laskey, T. Nydam, A. Wiseman, S. Biggins.

    Hepatology, Transplant Surgery and Nephrology, Univ. Colorado, Aurora, CO.

    Identification of which liver transplant candidates with severe kidney injury can have full recovery of renal function after liver only transplant is difficult. Avoiding unnecessary…
  • 2015 American Transplant Congress

    Outcome of Kidney Transplantation Using Right Versus Three Left Renal Arteries After Retroperitoneoscopic Donor Nephrectomy: A Single-Center Experience of 764 Cases

    K. Omoto, M. Okumi, T. Shimizu, D. Toki, H. Ishida, K. Tanabe.

    Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

    OBJECTIVE:In laparoscopic donor nephrectomy (LDN), technical problems are less common in the right side than in the left side. In addition, several study series have…
  • 2015 American Transplant Congress

    Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)

    C. Antoine,1 E. Savoye,1 F. Gaudez,2 G. Cheisson,3 M. Videcoq,4 B. Barrou,5 National Steering Committee of Donation After Circulatory Death.1

    1Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; 2Department of Urology, Saint Louis Hospital, Paris, France; 3Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; 4Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; 5Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; 6Department of Urology, University Hospital La Pitie, Paris, France.

    The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…
  • 2015 American Transplant Congress

    Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury

    K. Nakamura,1 M. Zhang,2 B. Ke,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.

    Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
  • 2015 American Transplant Congress

    Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia

    D. Aufhauser, Jr.,1 Z. Wang,1 S. Cheraghlou,1 T. Bhatti,2 W. Hancock,2,3 M. Levine.1,4

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA; 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; 3Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 4Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.

    Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
  • 2015 American Transplant Congress

    Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury

    H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.

    Department of Surgery, University of Pittsburgh, Pittsburgh, PA.

    Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…
  • 2015 American Transplant Congress

    Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways

    K. Nakamura,1 M. Zhang,2 B. Ke,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.

    Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, is essential for resistance against liver ischemia-reperfusion injury (IRI). We asked whether SIRT1 may affect cytoprotective…
  • 2015 American Transplant Congress

    The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation

    R. Johns,1,2 M. Laftsidis,2 E. Burrows,2 F. Edwards,2 E. Ablorsu,2 P. James,1 A. Phillips,1,2 A. Asderakis.2

    1University of Cardiff, Cardiff, United Kingdom; 2University Hospital of Wales, Cardiff, United Kingdom.

    IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
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