Articles tagged "Warm ischemia"

2016 American Transplant Congress
Comparison of Three Approaches for Laparoscopic Donor Nephrectomy: Transvaginal, Transumbilical Single Site and Retroperitoneal.
M. Miura, H. Higashiyama.
Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan.
Objectives: Reduction of burdens to live kidney donors are important. The aim of this study was to compare the surgical outcomes of 3 approaches we…
2016 American Transplant Congress
HO-1/SIRT1/p53 Axis Regulates Macrophage Activation and Attenuates Liver Ischemia-Reperfusion Injury in Mice.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: The mechanism by which macrophage heme oxygenase-1 (HO-1)-Sirtuin1 (SIRT1) signaling promotes resistance against inflammation response in liver ischemia-reperfusion injury (IRI) remains elusive. As tumor…
2015 American Transplant Congress
Activated Protein C Treatment Protects Steatotic and Non-Steatotic Livers Under Ischemia–Reperfusion Injury in Different Manner
A. Matsuda, N. Kuriyama, H. Kato, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Activated protein C (APC) is known to have the cytoprotective effect on liver ischemia–reperfusion injury (IRI) in rat models. However, it is unclear that whether…
2015 American Transplant Congress
Hydrogen Sulfide Restores Protective Capacity of University of Wisconsin Solution During Normothermic Preservation
J. Grewal,¹ I. Lobb,¹ M. Whiteman,³ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom.
Organ preservation solution is crucial in mitigating effects of ischemia reperfusion injury (IRI) associated with transplantation. Although University of Wisconsin (UW) solution is ideally suited…
2015 American Transplant Congress
Ischemic Cholangiopathy Following Liver Transplantation from Donation After Circulatory Death Donors: Role of Tissue Plasminogen Activator Flush
C. Kubal,¹ R. Mangus,¹ J. Fridell,¹ M. Wingler,² S. Nagai,¹ B. Ekser,¹ J. Tector.¹
¹Department of Surgery, Indiana University, Indianapolis, IN; ²Indiana Organ Procurement Organization, Indianapolis, IN.
Background: Formation of microthrombi within the peribiliary arterial plexus causing necrosis of biliary epithelium may be responsible for ischemic cholangiopathy (IC) after donation after circulatory…
2015 American Transplant Congress
Prediction of Delayed Graft Function By Means of a Web-Based Calculator in Living Related Kidney Transplant: Mexican Single Center Experience
G. Martinez-Mier,¹ E. Soto-Miranda,¹ M. Mendez Lopez,¹ L. Budar Fernandez,¹ M. Trujillo-Martinez,² A. Uscanga-Montesano,² D. Avila y Falfan.²
¹Organ Transplantation, IMSS UMAE189/HRAEV Nefrologia y Trasplantes de Veracruz, Veracruz, Mexico; ²Research, IMSS UMAE 189, Veracruz, Mexico.
Background: Delayed graft function (DGF) is associated with, poor graft survival. Irish validated a model to predict DGF for deceased donor transplants. The model was…
2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…
2015 American Transplant Congress
Predicting Renal Recovery After Liver Transplant With Severe Pretransplant Sub-Acute Kidney Injury: The Impact of Warm Ischemic Time
H. Laskey, T. Nydam, A. Wiseman, S. Biggins.
Hepatology, Transplant Surgery and Nephrology, Univ. Colorado, Aurora, CO.
Identification of which liver transplant candidates with severe kidney injury can have full recovery of renal function after liver only transplant is difficult. Avoiding unnecessary…
2015 American Transplant Congress
Outcome of Kidney Transplantation Using Right Versus Three Left Renal Arteries After Retroperitoneoscopic Donor Nephrectomy: A Single-Center Experience of 764 Cases
K. Omoto, M. Okumi, T. Shimizu, D. Toki, H. Ishida, K. Tanabe.
Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
OBJECTIVE:In laparoscopic donor nephrectomy (LDN), technical problems are less common in the right side than in the left side. In addition, several study series have…
2015 American Transplant Congress
Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)
C. Antoine,¹ E. Savoye,¹ F. Gaudez,² G. Cheisson,³ M. Videcoq,⁴ B. Barrou,⁵ National Steering Committee of Donation After Circulatory Death.¹
¹Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; ²Department of Urology, Saint Louis Hospital, Paris, France; ³Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; ⁴Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; ⁵Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; ⁶Department of Urology, University Hospital La Pitie, Paris, France.
The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…