Articles tagged "Warm ischemia"

2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…
2015 American Transplant Congress
Predicting Renal Recovery After Liver Transplant With Severe Pretransplant Sub-Acute Kidney Injury: The Impact of Warm Ischemic Time
H. Laskey, T. Nydam, A. Wiseman, S. Biggins.
Hepatology, Transplant Surgery and Nephrology, Univ. Colorado, Aurora, CO.
Identification of which liver transplant candidates with severe kidney injury can have full recovery of renal function after liver only transplant is difficult. Avoiding unnecessary…
2015 American Transplant Congress
Outcome of Kidney Transplantation Using Right Versus Three Left Renal Arteries After Retroperitoneoscopic Donor Nephrectomy: A Single-Center Experience of 764 Cases
K. Omoto, M. Okumi, T. Shimizu, D. Toki, H. Ishida, K. Tanabe.
Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
OBJECTIVE:In laparoscopic donor nephrectomy (LDN), technical problems are less common in the right side than in the left side. In addition, several study series have…
2015 American Transplant Congress
Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)
C. Antoine,¹ E. Savoye,¹ F. Gaudez,² G. Cheisson,³ M. Videcoq,⁴ B. Barrou,⁵ National Steering Committee of Donation After Circulatory Death.¹
¹Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; ²Department of Urology, Saint Louis Hospital, Paris, France; ³Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; ⁴Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; ⁵Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; ⁶Department of Urology, University Hospital La Pitie, Paris, France.
The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…
2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
2015 American Transplant Congress
Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury
H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.
Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…
2015 American Transplant Congress
Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, is essential for resistance against liver ischemia-reperfusion injury (IRI). We asked whether SIRT1 may affect cytoprotective…
2015 American Transplant Congress
The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation
R. Johns,^1,2 M. Laftsidis,² E. Burrows,² F. Edwards,² E. Ablorsu,² P. James,¹ A. Phillips,^1,2 A. Asderakis.²
¹University of Cardiff, Cardiff, United Kingdom; ²University Hospital of Wales, Cardiff, United Kingdom.
IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
2015 American Transplant Congress
Activated Protein C Treatment Protects Steatotic and Non-Steatotic Livers Under Ischemia–Reperfusion Injury in Different Manner
A. Matsuda, N. Kuriyama, H. Kato, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Activated protein C (APC) is known to have the cytoprotective effect on liver ischemia–reperfusion injury (IRI) in rat models. However, it is unclear that whether…