ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2017 American Transplant Congress

    Robotic Kidney Transplantation: Bakirkoy Experience.

    S. Sahin,1 V. Tugcu,1 A. Yavuzsan,1 F. Akbay,2 S. Apaydin.2

    1Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey; 2Nephrology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey

    INTRODUCTION AND OBJECTIVES: As minimal invasive treatments develop, most urologists have preferred minimally invasive methods in recent years. There is a great shift through laparoscopic…
  • 2017 American Transplant Congress

    Neutering Worsens Liver Ischemia/Reperfusion Injury in Both Male and Female Mice.

    D. Murken,1 D. Aufhauser Jr,1 S. Concors,1 Z. Wang,1 G. Ge,1 W. Hancock,2 M. Levine.1

    1Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; 2Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
  • 2017 American Transplant Congress

    Direct Intrahepatic Delivery of Pegylated-Catalase Is Protective in a Rat Ischemia-Reperfusion Injury Model.

    E. Beal,1 S. Black,1 J. Kim,1 V. Velazquez,2 K. Washburn,1 D. Hayes Jr.,3 B. Whitson.1

    1Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; 2Center for Vaccines and Immunity, The Research Institute at Nationwide Childrens Hospital, Columbus, OH; 3Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH

    Introduction: Ischemia-reperfusion injury (IRI) is characterized by cessation of blood flow to an organ or tissue leading to accumulation of toxic metabolites and free radicals,…
  • 2016 American Transplant Congress

    Protective Effects of Nrf2 Over-Activation in Myeloid Cells During Hepatic Ischemia Reperfusion Correlates with Stat3 Signaling in Hepatocytes.

    C. Harberg,1 L.-Y. Lee,1 S. Werner,2 D. Johnson,3 J. Johnson,3 D. Foley.1

    1Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; 2Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland; 3Pharmaceutical Sciences, University of Wisconsin School of Pharmacy, Madison, WI.

    Ischemia-reperfusion injury (IRI) is a consequence of liver resection and liver transplantation. The Nrf2-antioxidant response element pathway is a key mediator of cellular defense against…
  • 2016 American Transplant Congress

    Reciprocal Effects of HDAC1 and HDAC2 Deletion on Renal Cold Ischemia Survival and Nuclear Co-Repressor Complex Expression.

    D. Aufhauser Jr,1 D. Murken,1 Z. Wang,1 A. Samanta,2 G. Ge,1 T. Bhatti,3 W. Hancock,2,3 M. Levine.1

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 3Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.

    Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
  • 2016 American Transplant Congress

    Short, Cool and Well Oxygenated – HOPE for DCD Kidneys.

    P. Kron, A. Schlegel, O. de Rougemont, C. Oberkofler, P.-A. Clavien, P. Dutkowski.

    University Hospital, Zurich, Switzerland.

    Background Organs from donors after cardiac death (DCD) suffer from severe loss of function requiring development of innovative methods of preservation. A novel perfusion approach,…
  • 2016 American Transplant Congress

    Hydrogen Sulfide Supplementation Helps Mitigate Effects of Ischemia Reperfusion Injury in a Murine Model of Donation After Cardiac Death Renal Transplantation.

    J. Grewal,1 I. Lobb,1 M. Saha,2 J. Jiang,2 A. Haig,1 A. Sener.1,2

    1Microbiology & Immunology, University of Western Ontario, London, Canada; 2Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.

    Donation after cardiac death(DCD) renal grafts experience a combination of prolonged warm and cold ischemia leading to greater ischemia reperfusion injury(IRI) that results in higher…
  • 2016 American Transplant Congress

    Predictors of Urologic Complications After Pediatric En-Bloc Donor Kidney Transplantation.

    S. Kabagambe,1 A. De Mattos,2 R. Perez,1 C. Santhanakrishnan,1 J. Sageshima,1 C. Troppmann,1 J. McVicar.1

    1Surgery, University of California-Davis, Sacramento, CA; 2Transplant Nephrology, University of California-Davis, Sacramento, CA.

    Pediatric en-bloc kidney transplant (PEBKT) has expanded the donor pool. Association of donor characteristics and urologic complications is not well described. The objective of this…
  • 2016 American Transplant Congress

    Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.

    K. Nakamura,1 M. Zhang,2 B. Ke,1 S. Kageyama,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.

    Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, plays a key role in inflammation responses and stress resistance. Although SIRT1 may regulate innate activation…
  • 2016 American Transplant Congress

    Differential Effect of Delayed Graft Function (DGF) on Kidney Transplant Outcomes: When Does DGF Not Make a Difference?

    M. Khan,1 H. El-Hennawy,1 A. Farney,1 J. Rogers,1 G. Orlando,1 A. Reeves-Daniel,2 A. Palanisamy,2 M. Gautreaux,3 S. Iskandar,3 W. Doares,4 S. Kaczmorski,4 R. Stratta.1

    1Surgery, Wake Forest, Winston-Salem, NC; 2Internal Medicine, Wake Forest, Winston-Salem, NC; 3Pathology, Wake Forest, Winston-Salem, NC; 4Pharmacy, Wake Forest, Winston-Salem, NC.

    Delayed graft function (DGF), defined as need for dialysis in 1st week following kidney transplant (KT), is an early surrogate marker of organ quality and…
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