ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)

C. Antoine,1 E. Savoye,1 F. Gaudez,2 G. Cheisson,3 M. Videcoq,4 B. Barrou,5 National Steering Committee of Donation After Circulatory Death.1

1Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France
2Department of Urology, Saint Louis Hospital, Paris, France
3Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France
4Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France
5Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France
6Department of Urology, University Hospital La Pitie, Paris, France.

Meeting: 2015 American Transplant Congress

Abstract number: C37

Keywords: Donors, Graft failure, Kidney transplantation, non-heart-beating, Warm ischemia

Session Information

Session Name: Poster Session C: ECD/DCD/high KDPI

Session Type: Poster Session

Date: Monday, May 4, 2015

Session Time: 5:30pm-6:30pm

 Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT) < 150 min. In situ kidney perfusion was performed either in hypothermia with a double-balloon catheter (ISP) or in normothermia (nRP). Machine Perfusion was mandatory. Only non-sensitized recipients awaiting a 1st transplant were eligible. 374 kidney transplants from 2007 to 2012) were analyzed. nRP was performed in 35% of the cases, mean WIT was 135 min and mean cold ischemia time (CIT) was 14 hours.

Risk factors analysis of primary non function (PNF, n=33) and graft failure (eGFR < 30ml/min or graft loss at 1 year, n=55) were performed by logistic regression.

PNF risk factor was paradoxically donor age less than 35 y [OR=4.24, p=0.007]. Sensibility analysis shown a center effect.

Graft failure risk factors (excluding PNF) were donor age and BMI, in situ organ perfusion modalities, ISP duration, HLA mismatch, CIT in univariate analysis (p < 0.2). No effect of donor age, no flow period, WIT or CIT were found in multivariate analysis. A significant risk of graft failure was associated with high donor BMI [OR=1.12, < 0.001] and ISP (compared to nRP) [OR=2, p= 0.05].

One and 3-year graft survival (without censuring deaths) were significantly different according to donor type: 87% and 79% for uDCD, 87% and 78% for DBD ECD and 94% and 89% for DBD-SCD. After adjustment on recipient age in a Cox model, a significant higher risk of failure at 1 year remained in uDCD recipients compared to optimal DBD [HR = 0.537].

In conclusion, uDCD kidneys represent an additional source of valuable transplants. The use of nRP decreased the graft failure rate [OR=2], probably through mechanisms close to those described in preconditioning experiments.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Antoine C, Savoye E, Gaudez F, Cheisson G, Videcoq M, Barrou B. Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD) [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/lessons-learned-from-the-clinical-use-of-normothermic-regional-perfusion-nrp-in-uncontrolled-donation-after-circulatory-death-dcd/. Accessed May 20, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences