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Articles tagged "Viral therapy"

  • 2015 American Transplant Congress

    CMV prevalence in Mauritian and Indonesian Cynomolgus Macaques: Significance in Transplantation and CMV Disease Models

    K. Premanand,1 E. Szilagyi,1 J. Yu,1 R. Patel,1 A. Antony,1 M. Willman,2 D. Berman-Weinberg,2 D. Han,2 A. Vaidya,3 E. Silva,3 K. McHenry,3 D. Salomon,4 N. Kenyon,2 A. Bartholomew.1

    1University of Illinois, Chicago; 2Univerisity of Miami, Miami; 3University of Illinois, Urbana; 4Scripps, San Diego.

    Despite the finding that most macaques express high serologic titers of anti-CMV antibody, susceptibility to disease appears to be variable post-transplant. This observation led us…
  • 2015 American Transplant Congress

    African American Race Is an Independent Risk Factor for Cytomegalovirus Infection in Renal Transplant Recipients on Low-Dose Valganciclovir Prophylaxis

    S. Patel, S. Kuten, J. Loucks-DeVos, R. Knight, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    Safe and effective use of low-dose (450 mg/day) valganciclovir (VGC) for cytomegalovirus (CMV) prophylaxis in renal transplant recipients (RTRs) has been reported. However, it is…
  • 2015 American Transplant Congress

    The Role of Antiviral Prophylaxis for the Prevention of Epstein-Barr Virus (EBV) Associated Post-Transplant Lymphoproliferative Disease (PTLD) in Solid Organ Transplant Recipients: A Systematic Review

    M. AlDabbagh,1,2 M. Gitman,3 D. Kumar, A. Humar, C. Rotstein, S. Husain.1,3

    1Medicine, Division of Infectious Diseases, University Health Network, Toronto, On, Canada; 2Pediatrics, Division of Infectious Diseases, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia; 3Multi-Organ Transplant Unit, University Health Network, Toronto, ON, Canada.

    Background The role of antiviral prophylaxis in EBV seronegative solid organ transplant recipients receiving organs from seropositive donors for prevention of PTLD remains controversial. We…
  • 2015 American Transplant Congress

    Safety and Efficacy of Pegylated Interferon and Ribavirin for Chronic Hepatitis C Following Renal Transplantation

    G. Chen, L. Zhu, S. Chen, X. Wang, Z. Lin.

    Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.

    Objective We sought to investigate the safety and efficacy of pegylated Interferon (PEG-IFN) and ribavirin for chronic hepatitis C (HCV) following renal transplantation.Methods Ten adult…
  • 2015 American Transplant Congress

    Incidence of CMV Viremia in Obese and Morbidly Obese Kidney Transplants Under a Low Dose Valganciclovir Prophylaxis Protocol

    J. Thielke,1 P. West-Thielke,2 E. Benedetti.2

    1Pharmacy Practice, Univ of IL-Chicago, Chicago, IL; 2Surgery, Univ of IL-Chicago, Chicago, IL.

    Background: The rate of Cytomegalovirus infections in kidney transplant recipients drastically diminished with the advent of oral ganciclovir and subsequently valganciclovir. However it continues to…
  • 2015 American Transplant Congress

    Clinical and Virologic Outcomes in High-Risk Adult EBV D+/R- Organ Transplant Recipients

    D. Kumar, N. Patil, S. Husain, C. Chaparro, A. Humar.

    UHN, Toronto, Canada.

    Background:EBV D+/R- organ transplant recipients are a high risk group for developing PTLD. This subgroup of patients has been primarily evaluated in pediatric populations with…
  • 2015 American Transplant Congress

    Viral Prophylaxis Is Unnecessary in CMV Low Risk Kidney Transplant Recipients Who Receive Lymphocyte Depleting Induction

    M. Gillespie,1 B. Sirandas,2 A. Carlson,2 S. Lee,3 L. Smith.2

    1Pharmacy, University of Maryland, Baltimore; 2Transplant, University of Utah, Salt Lake City; 3Transplant, University of Southern California, Los Angeles.

    Background: Both the international CMV consensus and AST guidelines recommend against the routine use of CMV prophylaxis in CMV D-/R- kidney transplant recipients (KTR), but…
  • 2015 American Transplant Congress

    Efficacy of Sofosbuvir Based Therapy for Recurrent Hepatitis C After Liver Transplantation

    A. Weick,1 K. George,1 S.-M. Jafri,2 D. Moonka.2

    1Internal Medicine, Henry Ford Hospital, Detroit, MI; 2Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI.

    Purpose: Evaluate outcomes of sofosbuvir-based hepatitis C therapy in liver transplant patients in a single center clinical setting, including interferon-free regimens.Methods: All patients with history…
  • 2015 American Transplant Congress

    High Tolerability With Sofosbuvir-Based Direct-Acting Antiviral Therapy in Liver Transplant Recipients With Recurrent Hepatitis C

    B. Osborne,1 A. Modi,1 M. Gautam,1 N. Murray,1 I. Gonzalez,2 J. McAfee,2 S. Gonzalez.1

    1Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; 2Hepatology, Liver Consultants of Texas, Fort Worth, TX.

    Background: Reports on efficacy, safety, and tolerability of sofobuvir-based antiviral regimens in liver transplant recipients with recurrent hepatitis C are limited. Methods: We performed a…
  • 2015 American Transplant Congress

    Sofosbuvir-Based Therapy for Hepatitis C Recurrence Post Liver Transplantation

    A. Ajlan,1 A. Aljedai,1 H. Elsiesy,2 D. Alkortas,1 R. Alarieh,2 F. Aba Alkhail.2

    1Pharmaceutical Care Division, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; 2Liver And Small Bowel Trans and Hep/Pancreatic Surgey -Organ Transplant Centre (OTC), King Faisal Specialist Hospital and Research Centre, Riaydh, Saudi Arabia.

    Introduction:Sofosbuvir is approved to treat HCV infection in all genotypes with sustained virological response 12 weeks after completion of therapy (SVR12)rates of up to 100%.…
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