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Articles tagged "Viral therapy"

  • 2015 American Transplant Congress

    Sofosbuvir-Based Therapy for Hepatitis C Recurrence Post Liver Transplantation

    A. Ajlan,1 A. Aljedai,1 H. Elsiesy,2 D. Alkortas,1 R. Alarieh,2 F. Aba Alkhail.2

    1Pharmaceutical Care Division, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; 2Liver And Small Bowel Trans and Hep/Pancreatic Surgey -Organ Transplant Centre (OTC), King Faisal Specialist Hospital and Research Centre, Riaydh, Saudi Arabia.

    Introduction:Sofosbuvir is approved to treat HCV infection in all genotypes with sustained virological response 12 weeks after completion of therapy (SVR12)rates of up to 100%.…
  • 2015 American Transplant Congress

    End of Treatment Liver Biopsy With Sofosbuvir: Histologic Changes Suggestive of Hepatitis C Activity in Liver Transplant Recipients With Achieved SVR

    B. Ismail,1 X. Zervos,1 P. Bejarano,2 M. Waton,1 D. Beltran,3 D. Sears,1 A. Tzakis.1

    1Liver Transplant, Cleveland Clinic Florida, Weston, FL; 2Pathology, Cleveland Clinic Florida, Weston, FL; 3Pharmacy, Cleveland Clinic Florida, Weston, FL.

    Background: Interferon (IFN) free HCV regimens are associated with better tolerability and efficacy. The majority of studies report biochemical and virological response; however limited information…
  • 2015 American Transplant Congress

    Sofosbuvir Therapy in Early and Late Post Liver Transplant Setting: A Single Center Experience

    X. Zervos,1 D. Beltran,2 B. Ismail,1 M. Watson,1 D. Sears,1 A. Tzakis.1

    1Liver Transplant, Cleveland Clinic Florida, Weston, FL; 2Pharmacy, Cleveland Clinic Florida, Weston, FL.

    Background: Hepatitis C (HCV) treatment has entered a new phase of excitement with new oral therapies. Here we describe our experience of sofosbuvir (SOF) based…
  • 2015 American Transplant Congress

    Preventing Cytomegalovirus Infection in Intermediate-High Risk Liver Transplant Recipients: Acyclovir Vs Valganciclovir

    S. Dulanya, A. Anamisis, D. Tsapepas.

    Department of Pharmacy, New York Presbyterian Hospital, New York City, NY.

    Cytomegalovirus (CMV) is an opportunistic infection responsible for profound morbidity and mortality among solid organ transplant recipients. A donor and recipient's CMV IgG serostatus influences…
  • 2015 American Transplant Congress

    CMV prevalence in Mauritian and Indonesian Cynomolgus Macaques: Significance in Transplantation and CMV Disease Models

    K. Premanand,1 E. Szilagyi,1 J. Yu,1 R. Patel,1 A. Antony,1 M. Willman,2 D. Berman-Weinberg,2 D. Han,2 A. Vaidya,3 E. Silva,3 K. McHenry,3 D. Salomon,4 N. Kenyon,2 A. Bartholomew.1

    1University of Illinois, Chicago; 2Univerisity of Miami, Miami; 3University of Illinois, Urbana; 4Scripps, San Diego.

    Despite the finding that most macaques express high serologic titers of anti-CMV antibody, susceptibility to disease appears to be variable post-transplant. This observation led us…
  • 2015 American Transplant Congress

    African American Race Is an Independent Risk Factor for Cytomegalovirus Infection in Renal Transplant Recipients on Low-Dose Valganciclovir Prophylaxis

    S. Patel, S. Kuten, J. Loucks-DeVos, R. Knight, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    Safe and effective use of low-dose (450 mg/day) valganciclovir (VGC) for cytomegalovirus (CMV) prophylaxis in renal transplant recipients (RTRs) has been reported. However, it is…
  • 2015 American Transplant Congress

    The Role of Antiviral Prophylaxis for the Prevention of Epstein-Barr Virus (EBV) Associated Post-Transplant Lymphoproliferative Disease (PTLD) in Solid Organ Transplant Recipients: A Systematic Review

    M. AlDabbagh,1,2 M. Gitman,3 D. Kumar, A. Humar, C. Rotstein, S. Husain.1,3

    1Medicine, Division of Infectious Diseases, University Health Network, Toronto, On, Canada; 2Pediatrics, Division of Infectious Diseases, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia; 3Multi-Organ Transplant Unit, University Health Network, Toronto, ON, Canada.

    Background The role of antiviral prophylaxis in EBV seronegative solid organ transplant recipients receiving organs from seropositive donors for prevention of PTLD remains controversial. We…
  • 2015 American Transplant Congress

    Safety and Efficacy of Pegylated Interferon and Ribavirin for Chronic Hepatitis C Following Renal Transplantation

    G. Chen, L. Zhu, S. Chen, X. Wang, Z. Lin.

    Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.

    Objective We sought to investigate the safety and efficacy of pegylated Interferon (PEG-IFN) and ribavirin for chronic hepatitis C (HCV) following renal transplantation.Methods Ten adult…
  • 2015 American Transplant Congress

    Incidence of CMV Viremia in Obese and Morbidly Obese Kidney Transplants Under a Low Dose Valganciclovir Prophylaxis Protocol

    J. Thielke,1 P. West-Thielke,2 E. Benedetti.2

    1Pharmacy Practice, Univ of IL-Chicago, Chicago, IL; 2Surgery, Univ of IL-Chicago, Chicago, IL.

    Background: The rate of Cytomegalovirus infections in kidney transplant recipients drastically diminished with the advent of oral ganciclovir and subsequently valganciclovir. However it continues to…
  • 2015 American Transplant Congress

    Clinical and Virologic Outcomes in High-Risk Adult EBV D+/R- Organ Transplant Recipients

    D. Kumar, N. Patil, S. Husain, C. Chaparro, A. Humar.

    UHN, Toronto, Canada.

    Background:EBV D+/R- organ transplant recipients are a high risk group for developing PTLD. This subgroup of patients has been primarily evaluated in pediatric populations with…
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