2019 American Transplant Congress
Low Specific Gravity Of First Morning Urine Predicts Bkvn in Kidney Transplant Recipients With Bk Viruria
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. BKV usually infects urinary tract retrogradely. The collecting duct…2019 American Transplant Congress
The Impact of Antibiotic Therapy on Clinical Outcomes in Kidney Transplant Recipients with Asymptomatic Bacteriuria
1Michigan Medicine, Ann Arbor, MI, 2MedStar Georgetown University Hospital, Washington, DC
*Purpose: Asymptomatic bacteriuria (ASB) occurs in nearly 50% of kidney transplant recipients (KTRs) in the first year post-transplant. Data evaluating the risk of untreated ASB…2019 American Transplant Congress
Elevated Urinary Injury Biomarkers in Deceased Donors Are Not Associated with Long-Term Kidney Transplant Outcomes
*Purpose: In the United States, over 90,000 people are on the kidney transplant waiting list and could benefit from more donor organs. Kidneys from deceased-donors…2018 American Transplant Congress
Activity Nanosensors for Early and Noninvasive Detection of Acute Organ Transplant Rejection
Purpose: We engineered activity nanosensors that sense anti-allograft T cell activity in vivo to noninvasively detect the onset of acute cellular rejection from urine.Methods: Granzyme…2018 American Transplant Congress
Non-Invasive Diagnostic of Renal Allograft Rejection via Urine Metabolites Using NMR-Spectroscopy
Introduction and BackgroundPost-transplant surveillance for acute rejection is typically based on regular monitoring of serum creatinine levels and consecutive biopsies upon functional renal impairment. Attempts…2018 American Transplant Congress
Diagnostic Value and Confounding Factors of Urinary Biomarkers in the Non-Invasive Screening of Renal Allograft Inflammation
IntroductionThe value of urinary biomarkers has already been demonstrated in diagnosing acute rejection of the renal allograft, but confounding factors, which may interfere with their…2018 American Transplant Congress
Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients
Introduction: Tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are promising biomarkers in acute kidney injury. Here, we investigated the performance…2018 American Transplant Congress
Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplants
Background: Microbiome dysbiosis can lead to poor outcomes after kidney transplant (tx) presumably due to immune dysregulation elicited by the microbiome. We hypothesize that chronic…2018 American Transplant Congress
Urinary Tract Infections May Be Associated with De Novo Donor-Specific Anti-Human Leucocyte Antigen Antibodies: Single-Center Study
Introduction: We have recently shown that immunosuppression reduction with BK virus is associated with the development of de novo donor anti-human leukocyte antigen-specific antibodies (dnDSA).…2017 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Quantifies and Differentiates Kidney Transplant Injury.
1University of California San Francisco, San Francisco; 2Immucor Inc, Atlanta
We sought to investigate the use of the common rejection module (CRM) genes in the discrimination of AR, BKVN, and stable transplant phenotypes in urine…
American Transplant Congress abstracts