2022 American Transplant Congress
Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…2022 American Transplant Congress
Trajectory Analysis Of Single Cell RNAseq Data Suggest Intrarenal Induction Of Tregs In Spontaneously Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted independent of the recipient’s thymus, spleen, and lymph nodes.…2022 American Transplant Congress
A FRET-Based Technique to Quantify Foxp3 Acetylation in TREG
*Purpose: Foxp3 acetylation is essential to TREG stability and function. Acetylation protects Foxp3 from degradation, and acetylated Foxp3 translocates to the nucleus to activate the…2022 American Transplant Congress
Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes
*Purpose: The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot achieve induction of immune tolerance and their nonspecific…2022 American Transplant Congress
Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients
*Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…2022 American Transplant Congress
Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor
UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…2022 American Transplant Congress
Characterization Of Gzmb+ Bregs Using Single Cell Rnaseq
CRT2I INSERM UMR1064, Nantes, France
*Purpose: Granzyme B (GZMB)+ B cells are increased in blood from transplanted patients who tolerate a kidney graft without immunosuppressive treatment. We demonstrated that these…2022 American Transplant Congress
Leveraging Car T Cells To Achieve Desensitization And Enable Transplantation
UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA
*Purpose: Pre-existing allo-antibodies (allo-Abs), that preclude transplant due to the risk of hyperacute rejection, lead to prolonged wait times and high mortality rates. Current desensitization…2022 American Transplant Congress
Role of CD8+T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…
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