2022 American Transplant Congress
High Dimensional Analysis of IL-10-Producing Human B Cells and Their Characterization in Operationally Tolerant Transplant Recipients
Stanford University Sch of Med, Stanford, CA
*Purpose: Regulatory B cells (Breg) participate in control of alloimmune responses in murine models of graft tolerance and are associated with improved outcomes in clinical…2022 American Transplant Congress
Why Females Have Weaker Tregs Than Males: Inhibitory Effects of Estrogen Receptor Signaling on Foxp3+ Treg Cell Suppressive Function
*Purpose: Estrogen signaling is thought to play a role in nearly every cell type, but the biological significance of estrogen signaling via estrogen receptors in…2022 American Transplant Congress
Identification of a Unique and Mechanistic Urinary Cell mRNA Signature in Tolerant Kidney Transplant Recipients Conditioned with FCR001 Facilitating Cells
*Purpose: Urinary cell mRNA profiling is a powerful tool to interrogate kidney allograft status and can diagnose and anticipate acute rejection in kidney allograft recipients.…2022 American Transplant Congress
Brief Human IL-2 Mutein Therapy Induces Foxp3+ T-Regulatory Cell Expansion and Donor-Specific Allograft Tolerance
*Purpose: New therapeutic approaches to the management of transplant recipients are warranted in efforts to improve outcomes.*Methods: We have engineered a modified human IL-2 protein…2022 American Transplant Congress
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance
Surgery, University of Wisconsin, Madison, WI
*Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…2022 American Transplant Congress
Alloreactive Human Regulatory T Cell-Derived Extracellular Vesicles Exhibit Adenosinergic Mediated Suppression and Potential for Infectious Tolerance
Brigham and Women's Hospital, Boston, MA
*Purpose: Regulatory T cells (Tregs) suppress the immune response through both contact dependent and independent mechanisms. Extracellular vesicles (EVs) are emerging as novel contact independent…2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…2022 American Transplant Congress
Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance
*Purpose: We previously reported that B cells in recipients made tolerant to fully mismatched heart allografts by anti-CD154+donor spleen cells (CoB) become dysfunctional in their…2022 American Transplant Congress
Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation
*Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…2022 American Transplant Congress
Novel Peripheral Molecular Markers Predict Premature Graft Loss: Lessons Learned from Operational Tolerance Assessment
*Purpose: TOMOGRAM, European multicenter study, recently identified new cohort of kidney transplant recipients (KTR) with operational tolerance (OT) with the aim to identify new transcriptomic…
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