2018 American Transplant Congress
T Cell Immunomonitoring Including Donor Specific Treg Expansion Prospectively Predicts Renal Allograft Tolerance Induced by Transient Mixed Chimerism
Center for Transplant Science, Massachusetts General Hospital, Boston, MA.
Background: Successful induction of allograft tolerance in MHC-mismatched kidney transplantation has been achieved after induction of transient chimerism in both nonhuman primates (NHP) and humans.…2018 American Transplant Congress
Donor T Cells Undermine the Graft-Protective Effect of DST Plus Anti-CD154
Plastic Surgery, Johns Hopkins University, Baltimore, MD.
Costimulation blockade (CoB) regimens are a promising immunomodulatory strategy to prevent transplant rejection. However, their efficacy is affected by multiple factors, including still unknown ones.…2018 American Transplant Congress
Dual Function of IRF1/IRF4 on Dendritic Cells in Mouse Liver Transplantation Model
Tolerogenic dendritic cells play an essential role in transplant tolerance induction. However, how to induce tolerogenic dendritic cells is not fully understood. Here, we sorted…2018 American Transplant Congress
Dependency on CD4 T Cells, Foreign Protein, and CD22 for Generation of Antibody Response to Non-Self Blood Group A-Antigen in a Mouse Model
Background: ABO-incompatible heart transplantation (ABOi-HTx) is safe during infancy and allows increased donor access. B cell tolerance develops to donor A/B-antigens (Ag) after ABOi HTx…2018 American Transplant Congress
Confirmation of the Feasibility of Ex Vivo Creation of a Novel Human Multi-Chimeric Cells Therapy for Tolerance Induction in Vascularized Composite Allotransplantation
Orthopaedics, University of Illinois at Chicago, Chicago, IL.
Purpose:Various stem cell-based therapies have been proposed as supportive treatments for patients following solid organ and vascularized composite allotransplantation (VCA) to achieve donor-specific tolerance and…2018 American Transplant Congress
ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells
Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…2018 American Transplant Congress
Immunomodulation of Alloantibody Responses
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
We have shown that i.v. exposure to MHC-mismatched donor PBMC using a novel, mild conditioning protocol results in B-cell tolerance with transient T-cell unresponsiveness. Here…2018 American Transplant Congress
Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of naturally occurring, immunosuppressive cells that may be exploitable in transplantation.There are only a few incomplete…2018 American Transplant Congress
Age-Specific Effects of Tacrolimus Are Associated to Specific Changes of T Cell Metabolism
Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston.
Background: Energy metabolism of immune cells has been identified as critical in driving alloimmunity. While metabolic capacities change with aging, aspects linking age, immunosuppression, and…2018 American Transplant Congress
Differential Effects of Inhibiting Glycolysis on Human Treg Subsets
Department of Surgery, Massachusetts General Hospital, Boston, MA.
Regulatory T cells (Tregs) are a promising therapeutic tool for inducing transplantation tolerance. Tregs can be divided into those of thymic origin (tTreg) and those…
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