Articles tagged "Tolerance"

2018 American Transplant Congress
Human CD8⁺CD28^– T Cells Driven In Vitro by IL-15 Suppress in Allo-Specific Manner Partially through PD-1:PD-L1 Pathway
F. Feng,^1,2 G. Liu,¹ P. Zhu,¹ M. Zhu,¹ X. Lu,¹ J. Liu,² X. Luo,³ Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; ³Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Background: CD8+CD28- T suppressor cells (Ts) have emerged as an important modulator of alloimmunity, but the in vitro inducibility of Ts subsets is rather unclear.…
2018 American Transplant Congress
NOS2 Deficiency Limits Long Term Survival of Murine Kidney Allografts
I. Aljabban,^1,2 B. Jiang,¹ C. Yang,¹ T. O'Shea,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Pennsylvania State University College of Medicine, Hershey, PA.
Nitric oxide (NO) is a small molecule derived from L-arginine that governs a myriad of physiologic processes including the antimicrobial and tumoricidal responses. Although NO…
2018 American Transplant Congress
Does the End Justify the Means? An Analysis of Outcomes in Recipients of Combined Kidney/Hematopoietic Stem Cell (HSC) Transplants and Comparison to Standard of Care (SOC) Patients
J. Leventhal,¹ A. Shetty,¹ L. Gallon,¹ K. Kurtenbach,¹ D. Stare,¹ S. Ildstad.²
¹Northwestern U, Chicago; ²U Louisville, Louisville.
Eliminating the long term costs and side effects of immunosuppression (IS) is a compelling reason to pursue transplant tolerance. Tolerance in kidney transplant (KTx) pts…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…
2018 American Transplant Congress
Robust Hematopoietic Mixed Chimerism and Donor-Specific Skin Allograft Tolerance after Non-Genotoxic Anti-CD117 Immunotoxin Conditioning and Donor Bone Marrow Allotransplantation
Z. Li,¹ A. Czechowicz,^2,3,4,5,6,7 A. Scheck,^2,3,4,5,6 D. Rossi,^3,4,5,6 P. Murphy.¹
¹Lab of Molecular Immunology (LMI), NIAID, Bethesda; ²Dept Pediatrics, Div Stem Cell Transplantation and Regenerative Med, Stanford Univ, Stanford; ³Pgram Cellular & Molecular Med, Div Hematology/Oncology, Boston Children's Hosp, Boston; ⁴Dept Stem Cell & Regenerative Biol, Harvard Univ, Boston; ⁵Dept Pediatrics, Harvard Med Sch, Boston; ⁶Harvard Stem Cell Inst, Harvard Univ, Cambridge; ⁷Dept Pediatric Oncology, Dana Farber Cancer Inst, Boston.
Establishing hematopoietic chimerism enables donor-specific allograft tolerance; however, chimerism protocols typically require either genotoxic conditioning or mega-doses of donor bone marrow cells (BMC), impeding clinical…
2018 American Transplant Congress
Validation Study of Operational Tolerance Signatures in Korean Kidney Transplantation Recipients
J. Seo,¹ Y. Lee,¹ Y. Kim,¹ J. Moon,¹ K-.H. Jeong,¹ C-.D. Kim,² J. Park,³ B. Jeong,⁴ S-.H. Lee.¹
¹Department of Nephrology, School of Medicine, Kyung Hee University, Seoul, Korea; ²Department of Nephrology, Kyung-pook National University School of Medicine, Daegu, Korea; ³Department of Nephrology, Sungkyunkwan University, Samsung Hospital, College of Medicine, Seoul, Korea; ⁴Department of Nephrology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Background:A peripheral B cell population was significantly higher in drug-free operationally tolerant patients than those with stable graft function or acute rejection under standard immunosuppression.…
2018 American Transplant Congress
Post-Transplant High Dose Cyclophosphamide Treatment Induces Thymus-Independent Immune Tolerance of Vascularized Composite Allografts via Complete Depletion of the Alloreactive TCR Repertoire.
G. Furtmüller,¹ B. Oh,¹ J. Sidhom,² M. Fryer,¹ V. Malek,¹ X. Zhou,¹ D. Cooney,¹ C. Brayton,³ J. Dodd-o,⁴ S. Ganguly,² G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD; ³Department for Comparative Pathobiology, Johns Hopkins University, Baltimore, MD; ⁴Department of Anesthesiology, Johns Hopkins University, Baltimore, MD.
Background: Treatment with PT/Cy in the setting of combined donor bone marrow transplantation and VCA has shown encouraging results with regards to chimerism induction and…
2018 American Transplant Congress
Effect of Erythropoietin on Cardiac Allograft Survival in Non-Human Primates
J. O.,¹ K. Robinson,¹ W. Sommer,¹ K. Pruner,¹ J. Paster,¹ M. Hanekamp,¹ A. Dehnadi,¹ I. Rosales,¹ R. Smith,¹ P. Cravedi,² P. Heeger,² G. Benichou,¹ J. Madsen.¹
¹MGH, Boston; ²Icahn School of Medicine at Mount Sinai, New York.
Purpose: Tolerance of cardiac allografts has been achieved in cynomolgus monkeys for the first time via mixed hematopoietic chimerism and donor kidney co-transplantation, but the…
2018 American Transplant Congress
T Cell Lineage Imbalance and Regulatory Immune Populations in HCC Patients Undergoing Downstaging While Waitlisted for Liver Transplantation
P. Thevenot,¹ K. Nunez,¹ T. Sandow,² J. Gimenez,² J. Gonzalez-Rosario,¹ M. Patel,¹ A. Alfadhli,¹ D. Wyczechowska,³ A. Cohen.¹
¹Institute of Translational Research, Ochsner Health System, New Orleans, LA; ²Interventional Radiology, Ochsner Health System, New Orleans, LA; ³Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA.
Purpose:In this study, we monitored peripheral lymphocyte lineage and regulatory immune populations in HCC patients undergoing DEB-TACE as a bridge to liver transplantation.Methods: Liver transplant…
2018 American Transplant Congress
Anti-TIRC7 Antibody Acts Synergistically with Tacrolimus in Promoting Graft Survival in a Rat Kidney Transplant Model
S. Tullius,¹ Y. Kumamoto,² U. Nalan.³
¹Department of Medicine, Brigham and Women's Hospital, Boston, MA; ²Department of Surgery, Kitasato University School of Medicine, Kanagawa, Sagamihara, Japan; ³Institute for Medical Immunology, University Hospital Charite, Berlin, Germany.
Background: Induction of T cell immune response c-DNA (TIRC7) is restricted to activated lymphocytes. Modulation of TIRC7 signalling prevents immune activation specifically at the site…