Articles tagged "Tolerance"

2018 American Transplant Congress
Durable Donor Hematopoetic Stem Cell (HSC) Chimerism is Associated with Protection from Native Renal Disease Recurrence in Recipients of Combined HSC/Kidney Transplants
J. Leventhal,¹ L. Gallon,¹ J. Mathew,¹ J. Miller,¹ D. Stare,¹ S. Ildstad.²
¹Northwestern U, Chicago; ²U Louisville, Louisville.
Recurrence of the original cause of ESRD has been observed in trials of tolerance induction for kidney transplantation (KTx) where donor HSC have been used…
2018 American Transplant Congress
An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice
F. Lee,¹ A. Dangi,¹ M. Burnette,¹ X. Zhang,¹ B. Hering,² X. Luo.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Diabetes/Endocrinology, Diabetes Institute, Minneapolis, MN.
Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…
2018 American Transplant Congress
Enhancement of Intrinsic Apoptosis via Bcl-2 Inhibition Promotes Induction of Robust Mixed Chimerism and Renal Allograft Tolerance without Myelosuppression in Nonhuman Primates
T. Oura,¹ A. Dehnadi,¹ I. Rosales,¹ H. Sasaki,¹ P. Cippa,² R. Fehr,² A. Cosimi,¹ T. Kawai.¹
¹Surgery, Center for Transplantation Science, Massachusetts General Hospital, Boston, MA; ²Medicine, University of Zurich, Zurich, Switzerland.
Background: Successful induction of mixed chimerism (MC) and renal allograft tolerance has been achieved in both nonhuman primate (NHP) and man following conditioning that included…
2018 American Transplant Congress
Results of LITMUS (NCT 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski,¹ V. Rojas-Luengas,¹ A. Issacher,¹ J. Luo,⁴ H. Yowanto,⁴ N. Selzner,¹ L. Lilly,¹ R. Smith,¹ E. Renner,¹ J. Zhang,¹ D. Grant,¹ O. Adeyi,¹ H. Atkins,² P. Juni,³ G. Levy.¹
¹Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²The Ottawa Hospital Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa, ON, Canada; ³Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; ⁴SCIEX, Brea, CA.
Background: Previously we reported a novel biomarker gene set for the identification of tolerance in murine models of rapamycin-induced cardiac tolerance and spontaneous hepatic tolerance.…
2018 American Transplant Congress
Human CD8⁺CD28^– T Cells Driven In Vitro by IL-15 Suppress in Allo-Specific Manner Partially through PD-1:PD-L1 Pathway
F. Feng,^1,2 G. Liu,¹ P. Zhu,¹ M. Zhu,¹ X. Lu,¹ J. Liu,² X. Luo,³ Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; ³Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Background: CD8+CD28- T suppressor cells (Ts) have emerged as an important modulator of alloimmunity, but the in vitro inducibility of Ts subsets is rather unclear.…
2018 American Transplant Congress
NOS2 Deficiency Limits Long Term Survival of Murine Kidney Allografts
I. Aljabban,^1,2 B. Jiang,¹ C. Yang,¹ T. O'Shea,¹ D. Ndishabandi,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Pennsylvania State University College of Medicine, Hershey, PA.
Nitric oxide (NO) is a small molecule derived from L-arginine that governs a myriad of physiologic processes including the antimicrobial and tumoricidal responses. Although NO…
2018 American Transplant Congress
Does the End Justify the Means? An Analysis of Outcomes in Recipients of Combined Kidney/Hematopoietic Stem Cell (HSC) Transplants and Comparison to Standard of Care (SOC) Patients
J. Leventhal,¹ A. Shetty,¹ L. Gallon,¹ K. Kurtenbach,¹ D. Stare,¹ S. Ildstad.²
¹Northwestern U, Chicago; ²U Louisville, Louisville.
Eliminating the long term costs and side effects of immunosuppression (IS) is a compelling reason to pursue transplant tolerance. Tolerance in kidney transplant (KTx) pts…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…
2018 American Transplant Congress
Robust Hematopoietic Mixed Chimerism and Donor-Specific Skin Allograft Tolerance after Non-Genotoxic Anti-CD117 Immunotoxin Conditioning and Donor Bone Marrow Allotransplantation
Z. Li,¹ A. Czechowicz,^2,3,4,5,6,7 A. Scheck,^2,3,4,5,6 D. Rossi,^3,4,5,6 P. Murphy.¹
¹Lab of Molecular Immunology (LMI), NIAID, Bethesda; ²Dept Pediatrics, Div Stem Cell Transplantation and Regenerative Med, Stanford Univ, Stanford; ³Pgram Cellular & Molecular Med, Div Hematology/Oncology, Boston Children's Hosp, Boston; ⁴Dept Stem Cell & Regenerative Biol, Harvard Univ, Boston; ⁵Dept Pediatrics, Harvard Med Sch, Boston; ⁶Harvard Stem Cell Inst, Harvard Univ, Cambridge; ⁷Dept Pediatric Oncology, Dana Farber Cancer Inst, Boston.
Establishing hematopoietic chimerism enables donor-specific allograft tolerance; however, chimerism protocols typically require either genotoxic conditioning or mega-doses of donor bone marrow cells (BMC), impeding clinical…
2018 American Transplant Congress
Validation Study of Operational Tolerance Signatures in Korean Kidney Transplantation Recipients
J. Seo,¹ Y. Lee,¹ Y. Kim,¹ J. Moon,¹ K-.H. Jeong,¹ C-.D. Kim,² J. Park,³ B. Jeong,⁴ S-.H. Lee.¹
¹Department of Nephrology, School of Medicine, Kyung Hee University, Seoul, Korea; ²Department of Nephrology, Kyung-pook National University School of Medicine, Daegu, Korea; ³Department of Nephrology, Sungkyunkwan University, Samsung Hospital, College of Medicine, Seoul, Korea; ⁴Department of Nephrology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Background:A peripheral B cell population was significantly higher in drug-free operationally tolerant patients than those with stable graft function or acute rejection under standard immunosuppression.…