Articles tagged "Tolerance"

2018 American Transplant Congress
Closing Pandora's Box: An Evidence Based Approach to Opioid-Tolerant Patients Following Transplantation. The Case for IV Methadone
A. Aljassem, L. Hall, S. Cohn, D. Bedi, M. Alsibae, K. Putchakayala, S. Tasleem, D. Samarapungavan, C. Carpenter, A. Koffron.
Department of Surgery, Beaumont Health, Royal Oak, MI.
The purpose of this study is to explore the use of parenteral methadone in opioid-tolerant patients who are status-post transplantation. As an alternative to traditional…
2018 American Transplant Congress
Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction
J. Wu,^1,2 H. Zhang,¹ X. Shi,¹ X. Xiao,¹ Y. Fan,¹ J. Xia,² R. Sciammas,^1,3 X. Li,^1,3 W. Chen.^1,3
¹Center for Immunobiology & Transplant Science, Houston Methodist Research Institute, Houston, TX; ²Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ³Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…
2018 American Transplant Congress
Non-Myeloablative Conditioning with Low-Dose Total Body Irradiation in Place of Cyclophosphamide Induces Mixed Chimerism and Long-Term Immunosuppression Free Allograft Survival without Acute Kidney Injury in HLA Mismatched Kidney Transplantation
T. Kawai,¹ T. Spitzer,¹ T. Oura,¹ N. Torkoff-Rubin,¹ N. Elias,¹ M. Sykes,² R. Colvin,¹ D. Sachs,² A. Cosimi.¹
¹Transplant Center, Massachusetts General Hospital, Boston, MA; ²Center for Translational Immunology, Columbia University, New York, NY.
We have achieved successful induction of long-term immunosuppression (IS) free renal allograft survival in HLA mismatched kidney transplantation using cyclophosphamide (CP) based conditioning and combined…
2018 American Transplant Congress
The Regulatory Role of Plasma Cells (as Bregs) is Counterbalanced by a NOVEL Inflammatory Role in Murine Transplant and Autoimmune Models
Z. Song,^1,2 Y. Zhou,² Q. Ding,¹ D. Rothstein.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh; ²School of Medicine, Tsinghua University, Beijing, China.
Plasma Cells (PCs; B220lowCD138hiBlimp1+Ig+) in LN and spleen were shown to be the major source of B cell lineage IL-10, and absence of PCs worsens…
2018 American Transplant Congress
IL23R is a Pathogenic Gene in Type 1 Regulatory T Cells during Mouse Cardiac Transplantation Models
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.
IL23R has been confirmed to be a pathogenic gene in Th17 cells. However, its role in type 1 regulatory T cells (Tr1 cells) is not…
2018 American Transplant Congress
Melatonin Prolongs Heart Allograft Survival by Induction of Foxp3+ Regulatory T Cells
L. Liu, Q. Su, Y. Xiong, Z. Bi, H. Huang, Y. Peng, C. Wang.
The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
Objective: This study was aimed to investigate the effect of melatonin on heart allograft survival and explore the underlying mechanism. Methods and Results: Balb/c and…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2018 American Transplant Congress
Alloreactive B Cells Acquire Cell-Intrinsic Hyporesponsiveness in Tolerant Recipients
S. Khiew,¹ D. Jain,¹ J. Young,¹ J. Chen,¹ J. Yang,¹ Q. Wang,¹ D. Yin,¹ R. Sciammas,² A. Chong.¹
¹Department of Surgery, The University of Chicago, Chicago, IL; ²Comparative Medicine, University of California, Davis, CA.
Donor-specific transplantation tolerance has long been an aspiration of clinical transplantation. Recently, we have reported that multiple mechanisms are required to reinforce profound hyporesponsiveness of…
2018 American Transplant Congress
Immunity and Tolerance after Bilateral Orthotopic Lung Transplant (BOLT) in Tandem with a CD3+/CD19+ Depleted Vertebral Bone Marrow Transplant (BOLT+BMT) from 1 of 8 HLA-Matched Cadaveric Donors
P. Szabolcs,¹ X. Chen,¹ A. Donnenberg,² M. Hill,¹ J. Rowan,¹ S. Mcintyre,¹ G. Kurland,¹ J. Barnum,¹ J. McDyer.¹
¹BMT-CT, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; ²IDM-HCC, University of Pittsburgh, Pittsburgh, PA.
Primary immunodeficiency patients may develop pulmonary complications and most are ineligible for either lung transplant or BMT due to futility. We report our first 2…
2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…