2019 American Transplant Congress
Preliminary Mechanistic Studies of Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplant Recipients
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: This is a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation (LTx) in…2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…2019 American Transplant Congress
Long-Term Kidney Graft Evolution in Simultaneous Liver-Kidney Transplants with Immunological Risk
*Purpose: There is disagreement about the real impact of anti-HLA sensitization on patient and kidney graft survival in simultaneous liver-kidney transplant (SLKT).*Methods: We reviewed the…2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…2019 American Transplant Congress
Chimeric Allografts Induced by Stem Cell Mobilizing Agents in a Mouse Model of Kidney Transplantation: Role of CD133 Stem Cells
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: It has been reported that a stem cell mobilizing therapy using a combination of AMD3100 and low dose FK506 (AF) enabled immunosuppressive-free long-term kidney…2018 American Transplant Congress
Central Role of Mef2 Transcription Factors in Regulation of Foxp3 Expression and Treg Function
1CHOP, Philadelphia; 2UPenn, Philadelphia.
Foxp3+ Tregs express 4 class IIa Hdac enzymes (Hdac4, 5, 7 & 9) with little or no catalytic activity and yet when deleted, at least…2018 American Transplant Congress
A Phase-I Clinical Trial of Donor-Derived MIC Cell Infusion for the Induction of Donor-Specific Hyporesponsiveness after Living Donor Kidney Transplantation (TOL-1 Study)
MIC cells are donor-derived monocytes that gain immunosuppressive properties after incubation with the proliferation inhibitor mitomycin C.PBMCs were harvested from living donors by leukapheresis and…2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…2018 American Transplant Congress
Long Noncoding RNA NEAT1 Induces Tolerogenic Dendritic Cells in Heart Transplantation
Purpose: Tolerogenic dendritic cells have been gaining interest as an efficient means of promoting antigen-specific tolerance in organ transplantation. Long noncoding RNA NEAT1 plays an…2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…
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