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American Transplant Congress abstracts

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Articles tagged "T helper cells"

  • 2018 American Transplant Congress

    IL-17 is Critical for Airway Epithelial Injury after Transplantation

    R. Zhang,1 H. Fang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Obliterative bronchiolitis is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases. Th17…
  • 2018 American Transplant Congress

    IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection

    J. Breidenbach, C. Baum, P. Schroder, S. Stepkowski.

    Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Science, Toledo, OH.

    Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…
  • 2018 American Transplant Congress

    IL-6 Inhibition with Tocilizumab to Promote Tregs and Control Renal Graft Inflammation: A Prospective Randomized Controlled Trial

    S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Sarwal, F. Vincenti.

    UCSF, San Francisco.

    Background: IL-6, a proinflammatory cytokine & key regulator of Treg/Th17, is strongly associated with renal graft rejection. In theory, IL-6 blockade with tocilizumab (TCZ), a…
  • 2018 American Transplant Congress

    Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression

    S. Eskandari,1 M. Bandeira Melo,2 J. Assaker,1 A. Mansouri,1 S. Cai,1 B. Al Dulaijan,1 M. Mohamed,1 D. Irvine,2 J. Azzi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

    Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…
  • 2017 American Transplant Congress

    Pre-Transplant Circulating TNFR2+ Regulatory T Cells Predict Acute Rejection within the First 6 Months After Kidney Transplantation.

    M.-T. Nguyen,1 S. Sahakian,2 S. Liu,2 Y. Wang,2 J. Tchervenkov,2 S. Paraskevas.2

    1Department of Surgery, Columbia University, New York, NY; 2Department of Surgery, McGill University, Montreal, QC, Canada

    Background: Acute rejection (AR) mostly occurs during the first 6 months after kidney transplantation and contributes importantly to graft loss. Diagnosis relies on changes in…
  • 2017 American Transplant Congress

    TFR:TFH Cell Ratio Correlates with Anti-Donor Germinal Center Reactivity and Donor-Specific Antibody Formation Following Transplantation.

    G. La Muraglia II, M. Ford, I. Badell.

    Emory Transplant Center, Emory University School of Medicine, Atlanta, GA

    Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Although short-term outcomes are excellent, long-term allograft survival rates remain inadequate. It…
  • 2017 American Transplant Congress

    Differential Expression of Long Noncoding RNAs During Cardiac Allograft Rejection.

    G. Gu, H. Hang, T. Lu, Q. Xia.

    Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    While transplant rejection is the major restriction in successful long lasting graft survival, induction of sustainable immune tolerance against transplant is one of the major…
  • 2017 American Transplant Congress

    IL-21R Antagonist Inhibits Differentiation of B Cells Towards Plasmablasts upon Alloantigen Stimulation.

    K. de Leur,1,2 F. Dor,4 M. Dieterich,1 L. van der Laan,2 R. Hendriks,3 C. Baan.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Surgery, Division HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands; 3Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands; 4Imperial College Healthcare NHS Trust, London, United Kingdom

    Background: Antigen-specific antibody responses rely on IL-21+ T follicular helper (Tfh) cells that regulate B cell differentiation. In transplantation, a large proportion of renal allograft…
  • 2017 American Transplant Congress

    Activated Th1 and Th17 cTFH Phenotype Correlates with DSA Production in Kidney Transplant Recipients.

    C. Macedo, P. Fadakar, K. Hadi, B. Ellinof, A. Zeevi, S. Hariharan, D. Metes.

    University of Pittsburgh, Starzl Transplantation Institute, Pittsburgh

    Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…
  • 2017 American Transplant Congress

    The Treg/Th17 Axis: A Dynamic Balance Regulated by Stromal Laminins.

    T. Simon, J. Bromberg.

    University of Maryland, Baltimore

    Background: Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively…
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