ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T helper cells"

  • 2019 American Transplant Congress

    CD4 T Cell is Essential in an Innate-Immune Driven Ischemia-Reperfusion Injury in Mouse and Human

    S. Kageyama1, K. Kadono1, H. Hirao1, K. Nakamura1, T. Ito2, K. J. Dery1, D. Oncel1, R. A. Sosa3, E. F. Reed3, F. M. Kaldas2, R. W. Busuttil2, J. W. Kupiec-Weglinski1, Y. Zhai1

    1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, 3Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA

    *Purpose: Although CD4 T cells are critical in the mechanism of allograft rejection, little is known about their role in the innate immune-driven ischemia-reperfusion injury…
  • 2019 American Transplant Congress

    Impact of Everolimus Therapy on HIV Persistence and Gene Expression in Transplant Patients

    A. Zarinsefat1, C. Schreiner1, C. Cameron2, S. Chu1, M. P. Busch1, T. Liegler1, S. G. Deeks1, T. J. Henrich1, P. G. Stock1

    1UC San Francisco, San Francisco, CA, 2Case Western Reserve University, Cleveland, OH

    *Purpose: mTOR is a key regulatory kinase that controls cell-cycle progression. mTOR inhibitors have been shown to reduce expression of CCR5 and promote viral transcriptional…
  • 2019 American Transplant Congress

    T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance

    C. M. McIntosh1, M. L. Miller2, Y. Wang1, A. Chong3, M. Alegre1

    1Department of Medicine, University of Chicago, Chicago, IL, 2Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 3Department of Surgery, University of Chicago, Chicago, IL

    *Purpose: Donor-specific tolerance offers many advantages over current lifelong non-specific immunosuppression strategies, but the mechanisms by which it may be durably maintained remain to be…
  • 2019 American Transplant Congress

    Costimulation Blockade Modulates Humoral Responses in Highly Sensitized Transplant Recipients

    J. Kwun, B. Ezekian, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Yi, S. Knechtle

    Surgery, Duke Transplant Center, Durham, NC

    *Purpose: Broad human leukocyte antigen sensitization is a significant barrier to successful solid organ transplantation. Sensitized patients have poor access to donor organs, high wait…
  • 2019 American Transplant Congress

    Xenorejection of Porcine Islets in Humanized Mice is Dominated by a Human Th17 Cytokine Immune Response

    F. T. Lee1, A. Dangi2, M. Burnette2, B. Hering3, X. Luo2

    1Transplant Surgery, Northwestern University, Chicago, IL, 2Nephrology, Duke University, Durham, NC, 3Diabetes Institute, University of Minnesota, Minneapolis, MN

    *Purpose: We have previously shown that interleukin(IL)-17 producing CD4 T cells (Th17 response) dominate in the early anti-donor immune responses of a pig-to-mouse xenogeneic model…
  • 2019 American Transplant Congress

    Circulating T Follicular Helper Proliferation And Memory B Cell Activation Correlate With Donor Specific Allo-antibody Occurrence And Antibody-mediated Rejection After Kidney Transplantation

    K. Louis1, C. Macedo1, M. Marrari1, B. Ramaswami1, M. Lucas1, B. Elinoff1, M. Yamada1, X. Gu1, G. Chalasani1, A. Zeevi1, P. Randhawa1, C. Lefaucheur2, D. Metes1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Inserm Unité mixte de recherche 1160, Paris, France

    *Purpose: Crosstalk between T follicular helper (Tfh) cells and B cells is necessary for class-switched antibody generation. The contribution of memory Tfh and B cells…
  • 2019 American Transplant Congress

    Erythropoietin Ameliorates Parent to F1 Murine Graft versus Host Disease by Inhibiting TFH

    A. Angeletti1, C. Donadei1, A. Cumpelik1, C. Cantarelli1, C. Guglielmo1, G. La Manna2, P. Heeger1, P. Cravedi1

    1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 2Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale (DIMES), Policlinico Sant'Orsola-Malpighi, Bologna, Italy

    *Purpose: Building upon our previously generated evidence that erythropoietin (EPO) directly inhibits effector T cells (JASN 2015, 2017) and reduces autoantibody formation in murine lupus,…
  • 2019 American Transplant Congress

    Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression

    Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius

    Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA

    *Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…
  • 2019 American Transplant Congress

    The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?

    L. Belyayev1, M. Sadat2, K. Loh3, S. Moturi2, K. Khan2, J. Hawksworth2, C. Matsumoto2, T. M. Fishbein2, A. Kroemer2

    1Surgery, Walter Reed National Military Medical Center, Bethesda, MD, 2Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, 3Pediatrics, Children’s National Medical Center, Washington D.C., DC

    *Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
  • 2018 American Transplant Congress

    OX40 Costimulation Prevents Induction of Foxp3+ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression

    X. Zhang,1 X. Xiao,1 P. Lan,1 J. Li,1 Y. Dou,1 W. Chen,1 N. Ishii,2 S. Chen,1 E. Taparowsky,3 X. Li.1,4

    1Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX; 2Department of Microbiology and Immunology, Tohoku University, Sendai, Japan; 3Department of Biological Sciences, Perdue University, Lafayette, IN; 4Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.

    Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…
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