2018 American Transplant Congress
OX40 Costimulation Prevents Induction of Foxp3+ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression
Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…2018 American Transplant Congress
Circulating Follicular Helper T Cells (cTfh) in Renal Transplantation: Utility as Rejection Biomarker
Introduction: Antibody (Ab) mediated rejection is responsible for 30-50% of renal graft failures. Follicular helper T cells (Tfh) are required for the differentiation of B…2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…2018 American Transplant Congress
Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation
Background: Proinflammatory cytokine IL-6 increases effector/memory T-cells, induces Th17 cells and prevents the induction of Tregs. IL-6 expression in kidney biopsies is elevated during acute…2018 American Transplant Congress
IL23R is a Pathogenic Gene in Type 1 Regulatory T Cells during Mouse Cardiac Transplantation Models
IL23R has been confirmed to be a pathogenic gene in Th17 cells. However, its role in type 1 regulatory T cells (Tr1 cells) is not…2018 American Transplant Congress
Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway
Hsp70, a highly conserved protein, has been shown to induce strong immune responses and to reduce inflammation. However, its mechanism is not clear, especially in…2018 American Transplant Congress
Defining T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
BackgroundVascularized Composite Allotransplantation (VCA) is a clinically feasible therapeutic option for complex tissue defects. The highly immunogenic skin component of VCA represents a therapeutic challenge…2018 American Transplant Congress
Peripheral but Not Follicular T Helper Cells Are Activated by Allogeneic Human Endothelial Cells under IRI-Like Conditions and Promote Donor Specific Antibody
Background: Perioperative ischemia reperfusion injury (IRI) is a consequence of solid organ allograft transplantation that primes the graft for future rejection.Methods: We developed an in…2018 American Transplant Congress
Influence of Dendritic Cell Subsets on Enhancing Oral Tolerance in Cardiac Transplantation Model
Oral tolerance has been implicated in the protection of transplant rejection in the animal models. Antigen presenting cells (APCs) are responsible for sampling their environment…2018 American Transplant Congress
Shikonin Inhibits Th17 Development through Repressing STAT3 Activation
Background: Th17-mediated inflammatory responses are detrimental for allograft acceptance and long-term survival after transplantation. Shikonin is a naphthoquinone pigment isolated from a traditional medicinal herb…
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