2020 American Transplant Congress
Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter
*Purpose:2020 American Transplant Congress
Desensitization for Deceased Donor Transplantation: Testing a New Paradigm in the Nonhuman Primate
*Purpose: Desensitization regimens have rarely been applied to deceased donor allotransplantation. We hypothesized that belatacept monotherapy during a simulated deceased donor waiting list period would…2020 American Transplant Congress
Anti-Thymocyte Globulin Promotes Tfh Cells Differentiation and Alloantibody Production
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody-mediated rejection is a major cause of long-term graft loss. T follicular helper (Tfh) cell is CD4+ T cell subset that is specialized in…2020 American Transplant Congress
Activated Circulating Memory T Follicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…2020 American Transplant Congress
Multifaceted Roles of Follicular T Cell Subsets in Controlling Antibody Mediated Rejection
Renal- Transplant Research Center, Brigham and Women's Hospital- Harvard Medical School, Boston, MA
*Purpose: Assess the roles of T Follicular Helper and Regulatory cells in controlling pathogenic donor-specific antibodies (DSA) and antibody-mediated rejection(AbMR) during kidney transplantation.*Methods: Here we…2020 American Transplant Congress
ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level
Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: We showed that human infants become tolerant to donor A/B-antigens (Ag) after ABO-incompatible heart transplantation (ABOi-HTx) by mechanisms not well-defined. To expand ABOi-HTx effectively…2020 American Transplant Congress
CD4+ T-Cells Express High Levels of Messenger RNA Coding for Heparanase in Cultures with Matrigel
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Heparanase (Hpse) is the sole heparan sulfate (HS) degrading enzyme regulating multiple biological activities that enhance immune cell migration, blood vessel growth and cell…2020 American Transplant Congress
Targeting Th17: TIGIT as a Key Regulator of Tregs/Th17 Cells in Belatacept Resistant Rejection
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept resistant-rejection (BRR) is a major barrier to the widespread adoption of immune checkpoint blockade therapeutics in transplantation. Our lab has shown that patients…2020 American Transplant Congress
Novel Treatment of Acute Antibody-Mediated Rejection in a Nonhuman Primate Model of Kidney Allotransplantation
*Purpose: One third of sensitized, HLA-incompatible transplant recipients experience acute antibody mediated rejection (AMR) with limited treatment options. We tested a novel treatment strategy for…
American Transplant Congress abstracts