2022 American Transplant Congress
Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…2022 American Transplant Congress
T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism
*Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…2022 American Transplant Congress
Batf3 and IRF4 in Control of iTreg Differentiation, Stability, and Survival
Houston Methodist Research Institute, Houston, TX
*Purpose: The use of in vitro-differentiated induced Tregs (iTregs) in transplantation and various diseases is a promising therapeutic that is limited by challenges to iTreg…2022 American Transplant Congress
TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3+ Treg
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept-based immunosuppression confers fewer off-target toxicities compared to CNI but comes at a cost of increased incidence and severity of acute rejection, potentially due…2021 American Transplant Congress
CD40 Blockade by the Fc-Silent Immunosuppressive Antibody Iscalimab Results in Diminished B Cell Activation and Differentiation and is Paralleled by Whole Blood Gene Expression Data
1Erasmus MC, Rotterdam, Netherlands, 2Novartis Pharmaceuticals AG, Basel, Switzerland
*Purpose: Blockade of costimulatory molecule CD40 by the Fc-silent immunosuppressive drug Iscalimab has shown to inhibit acute alloreactivity in non-human primates and is currently being…2021 American Transplant Congress
Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways
*Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…2021 American Transplant Congress
Invariant Nkt Cells Promote Expansion of Novel Cxcr3+Ccr4+Cd8+ T Cells in the Liver Following Allogeneic Hepatocyte Transplant
*Purpose: Hepatocyte transplantation represents a treatment for metabolic diseases and a bridge therapy to whole organ transplant but is limited in part by cell immunogenicity.…2021 American Transplant Congress
Targeting Il-21 Receptor Shifts Tfh/tfr Balance and Ameliorateschronic Antibody Mediated Rejection
Tianjin First Central Hospital, Tianjin, China
*Purpose: Donor specific antibody (DSA) plays a central role in chronic kidney allograft injury. As a trigger of humoral alloimmune response, follicular T helper cells(Tfh)…2021 American Transplant Congress
Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation
Department of Surgery, Emory, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…2020 American Transplant Congress
Targeting Th17: TIGIT as a Key Regulator of Tregs/Th17 Cells in Belatacept Resistant Rejection
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: Belatacept resistant-rejection (BRR) is a major barrier to the widespread adoption of immune checkpoint blockade therapeutics in transplantation. Our lab has shown that patients…
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