2019 American Transplant Congress
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent
Emory Transplant Center, Atlanta, GA
*Purpose: Clinical costimulation blockade of the CD28 pathway in the form of CTLA-4Ig has shown the ability to attenuate T cell dependent DSA responses. However,…2019 American Transplant Congress
Memory T Follicular Helper Cell Alloresponse is Memory B Cell Independent and Inhibited by CD28 Costimulation Blockade
Emory University School of Medicine, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but reliable and durable therapeutic options to prevent or eliminate donor-specific antibodies (DSA)…2019 American Transplant Congress
Early CXCR5+PD1+ICOS+ Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation
*Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…2019 American Transplant Congress
Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics
1RIMUHC, Montreal, QC, Canada, 2SSM Health Saint Louis University Hospital, St. Louis, MO
*Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…2019 American Transplant Congress
Increased Ratio of Circulating Tfh for Tfr Cells in Chronic Renal Allograft Dysfunction: A Pilot Study
West China Hospital OF Sichuan University, Chengdu, China
*Purpose: T follicular helper (Tfh) cells play a central role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit…2019 American Transplant Congress
ICOS+PD-1+ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation
Emory Transplant Center, Atlanta, GA
*Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…2019 American Transplant Congress
Resistance of T Follicular Helper Cells to Depletion by Anti-Thymocyte Globulin
*Purpose: T follicular helper (Tfh) cells are a subset of CD4+ T cells that specializes in providing help for germinal center (GC) reactions where B…2019 American Transplant Congress
Inhibition of Th1 and Th17 Cell Differentiation and Prolonged Graft Survival through NFAT Pathway Downregulation
*Purpose: Extracts Aglaia (family Meliaceae) plants, specially Rocaglamide are used treatment strategy of autoimmune Inflammatory disease and allergic disease in traditional medicine in many Asia…2019 American Transplant Congress
CD4 T Cell is Essential in an Innate-Immune Driven Ischemia-Reperfusion Injury in Mouse and Human
*Purpose: Although CD4 T cells are critical in the mechanism of allograft rejection, little is known about their role in the innate immune-driven ischemia-reperfusion injury…2019 American Transplant Congress
Impact of Everolimus Therapy on HIV Persistence and Gene Expression in Transplant Patients
1UC San Francisco, San Francisco, CA, 2Case Western Reserve University, Cleveland, OH
*Purpose: mTOR is a key regulatory kinase that controls cell-cycle progression. mTOR inhibitors have been shown to reduce expression of CCR5 and promote viral transcriptional…
American Transplant Congress abstracts