2018 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…2018 American Transplant Congress
IL-6 Inhibition with Tocilizumab to Promote Tregs and Control Renal Graft Inflammation: A Prospective Randomized Controlled Trial
Background: IL-6, a proinflammatory cytokine & key regulator of Treg/Th17, is strongly associated with renal graft rejection. In theory, IL-6 blockade with tocilizumab (TCZ), a…2018 American Transplant Congress
Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression
Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…2018 American Transplant Congress
OX40 Costimulation Prevents Induction of Foxp3+ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression
Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…2018 American Transplant Congress
Circulating Follicular Helper T Cells (cTfh) in Renal Transplantation: Utility as Rejection Biomarker
Introduction: Antibody (Ab) mediated rejection is responsible for 30-50% of renal graft failures. Follicular helper T cells (Tfh) are required for the differentiation of B…2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…2018 American Transplant Congress
Immunologic Impact of Tocilizumab Treatment in Kidney Transplant Recipients with Allograft Inflammation
Background: Proinflammatory cytokine IL-6 increases effector/memory T-cells, induces Th17 cells and prevents the induction of Tregs. IL-6 expression in kidney biopsies is elevated during acute…2018 American Transplant Congress
IL23R is a Pathogenic Gene in Type 1 Regulatory T Cells during Mouse Cardiac Transplantation Models
IL23R has been confirmed to be a pathogenic gene in Th17 cells. However, its role in type 1 regulatory T cells (Tr1 cells) is not…2018 American Transplant Congress
Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway
Hsp70, a highly conserved protein, has been shown to induce strong immune responses and to reduce inflammation. However, its mechanism is not clear, especially in…2018 American Transplant Congress
Defining T Cell Subsets Involved in Rejection of Vascularized Composite Allografts
BackgroundVascularized Composite Allotransplantation (VCA) is a clinically feasible therapeutic option for complex tissue defects. The highly immunogenic skin component of VCA represents a therapeutic challenge…
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