ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T helper cells"

  • 2018 American Transplant Congress

    Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway

    G. Gu, T. Lu, N. Xu, Q. Xia.

    Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.

    Hsp70, a highly conserved protein, has been shown to induce strong immune responses and to reduce inflammation. However, its mechanism is not clear, especially in…
  • 2018 American Transplant Congress

    Defining T Cell Subsets Involved in Rejection of Vascularized Composite Allografts

    G. Furtmueller,1 V. Malek,1 B. Oh,1 S. Reddy,1 M. Iglesias,1 G. Raimondi,1 G. Brandacher, D. Cooney.

    1Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; 2Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore.

    BackgroundVascularized Composite Allotransplantation (VCA) is a clinically feasible therapeutic option for complex tissue defects. The highly immunogenic skin component of VCA represents a therapeutic challenge…
  • 2018 American Transplant Congress

    Peripheral but Not Follicular T Helper Cells Are Activated by Allogeneic Human Endothelial Cells under IRI-Like Conditions and Promote Donor Specific Antibody

    W. Fu,1 P. Yoo,2 J. Pober,3 D. Jane-wit.1

    1Cardiovascular Medicine, Yale School of Medicine, New Haven, CT; 2Surgery, Yale School of Medicine, New Haven, CT; 3Immunobiology, Yale School of Medicine, New Haven, CT.

    Background: Perioperative ischemia reperfusion injury (IRI) is a consequence of solid organ allograft transplantation that primes the graft for future rejection.Methods: We developed an in…
  • 2018 American Transplant Congress

    Influence of Dendritic Cell Subsets on Enhancing Oral Tolerance in Cardiac Transplantation Model

    G. Gu, T. Lu, N. Xu, Q. Xia.

    Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University Medical School, Shanghai, China.

    Oral tolerance has been implicated in the protection of transplant rejection in the animal models. Antigen presenting cells (APCs) are responsible for sampling their environment…
  • 2018 American Transplant Congress

    Shikonin Inhibits Th17 Development through Repressing STAT3 Activation

    H. Fang,1 R. Zhang,1 F. Liang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Th17-mediated inflammatory responses are detrimental for allograft acceptance and long-term survival after transplantation. Shikonin is a naphthoquinone pigment isolated from a traditional medicinal herb…
  • 2018 American Transplant Congress

    Circulating T Follicular Helper Cells Expand Following Transplantation and Exhibit a CD44hi Phenotype That Correlates with Peak Germinal Center Alloreactivity

    G. La Muraglia II, M. Wagener, M. Ford, R. Badell.

    Emory Transplant Center, Atlanta.

    It is increasingly well-recognized that donor-specific antibodies (DSA) play a significant role in the development of chronic rejection and fibrosis that contribute to late renal…
  • 2018 American Transplant Congress

    IL-17 is Critical for Airway Epithelial Injury after Transplantation

    R. Zhang,1 H. Fang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Obliterative bronchiolitis is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases. Th17…
  • 2018 American Transplant Congress

    IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection

    J. Breidenbach, C. Baum, P. Schroder, S. Stepkowski.

    Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Science, Toledo, OH.

    Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…
  • 2018 American Transplant Congress

    IL-6 Inhibition with Tocilizumab to Promote Tregs and Control Renal Graft Inflammation: A Prospective Randomized Controlled Trial

    S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Sarwal, F. Vincenti.

    UCSF, San Francisco.

    Background: IL-6, a proinflammatory cytokine & key regulator of Treg/Th17, is strongly associated with renal graft rejection. In theory, IL-6 blockade with tocilizumab (TCZ), a…
  • 2018 American Transplant Congress

    Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression

    S. Eskandari,1 M. Bandeira Melo,2 J. Assaker,1 A. Mansouri,1 S. Cai,1 B. Al Dulaijan,1 M. Mohamed,1 D. Irvine,2 J. Azzi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

    Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…
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