Articles tagged "T helper cells"

2019 American Transplant Congress
The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?
L. Belyayev¹, M. Sadat², K. Loh³, S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. M. Fishbein², A. Kroemer²
¹Surgery, Walter Reed National Military Medical Center, Bethesda, MD, ²Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, ³Pediatrics, Children’s National Medical Center, Washington D.C., DC
*Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
2019 American Transplant Congress
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent
G. M. La Muraglia II, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Clinical costimulation blockade of the CD28 pathway in the form of CTLA-4Ig has shown the ability to attenuate T cell dependent DSA responses. However,…
2019 American Transplant Congress
Memory T Follicular Helper Cell Alloresponse is Memory B Cell Independent and Inhibited by CD28 Costimulation Blockade
S. Zeng, G. M. La Muraglia II, M. L. Ford, I. R. Badell
Emory University School of Medicine, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but reliable and durable therapeutic options to prevent or eliminate donor-specific antibodies (DSA)…
2019 American Transplant Congress
Early CXCR5⁺PD1⁺ICOS⁺Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation
R. Danger¹, M. Chesneau¹, F. Delbos², S. Lebot¹, C. Kerleau¹, A. Chenouard¹, A. Cesbron², M. Giral³, S. Brouard³
¹CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France, ²Laboratoire Histocompatibilité et Immunogénétique - Etablissement Français du sang, Nantes, France, ³Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques, Fondation Centaure, CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France
*Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…
2019 American Transplant Congress
Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics
J. Tchervenkov¹, M. Nguyen², S. Negi¹, S. Paraskevas¹
¹RIMUHC, Montreal, QC, Canada, ²SSM Health Saint Louis University Hospital, St. Louis, MO
*Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…
2019 American Transplant Congress
Increased Ratio of Circulating Tfh for Tfr Cells in Chronic Renal Allograft Dysfunction: A Pilot Study
L. Yan, Y. Li, Y. Li, X. Wu, X. Wang, L. Wang, Y. Shi, J. Tang
West China Hospital OF Sichuan University, Chengdu, China
*Purpose: T follicular helper (Tfh) cells play a central role in contribution of B cell differentiation and antibody production. T follicular regulatory (Tfr) cells inhibit…
2019 American Transplant Congress
ICOS⁺PD-1⁺ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation
G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…
2019 American Transplant Congress
Resistance of T Follicular Helper Cells to Depletion by Anti-Thymocyte Globulin
M. Pérez-Sáez¹, N. Murakami², T. J. Borges², P. T. Sage², J. Pascual¹, L. V. Riella²
¹Nephrology, Hospital del Mar, Barcelona, Spain, ²Brigham and Women´s Hospital, Harvard Medical School, Boston, MA
*Purpose: T follicular helper (Tfh) cells are a subset of CD4+ T cells that specializes in providing help for germinal center (GC) reactions where B…
2019 American Transplant Congress
Inhibition of Th1 and Th17 Cell Differentiation and Prolonged Graft Survival through NFAT Pathway Downregulation
C. Dai¹, R. Tan¹, B. Yang¹, J. Markmann², D. Chen¹, L. Wei¹, Z. Chen¹
¹Institute of Organ Transplantation, Wuhan, China, ²Division of Transplantation, Boston, American Samoa
*Purpose: Extracts Aglaia (family Meliaceae) plants, specially Rocaglamide are used treatment strategy of autoimmune Inflammatory disease and allergic disease in traditional medicine in many Asia…
2018 American Transplant Congress
Influence of Dendritic Cell Subsets on Enhancing Oral Tolerance in Cardiac Transplantation Model
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University Medical School, Shanghai, China.
Oral tolerance has been implicated in the protection of transplant rejection in the animal models. Antigen presenting cells (APCs) are responsible for sampling their environment…