ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cells"

  • 2018 American Transplant Congress

    BK Polyomavirus (BKPyV)-Specific T Cells as a Diagnostic and Prognostic Marker for BKPyV-Infections after Pediatric Kidney Transplantation

    T. Ahlenstiel-Grunow,1 M. Sester,2 U. Sester,3 L. Pape.1

    1Pediatric Nephrology, Hannover Medical School, Hannover, Germany; 2Transplant and Infection Immunology, Saarland University, Homburg, Germany; 3Internal Medicine IV, Saarland University, Homburg, Germany.

    After kidney transplantation (KTx) immunosuppressive therapy causes an impaired cellular immune defense resulting in an increased risk of BKPyV-nephropathy (BKPyVAN). Prognostic markers for the outcome…
  • 2018 American Transplant Congress

    Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction

    J. Wu,1,2 H. Zhang,1 X. Shi,1 X. Xiao,1 Y. Fan,1 J. Xia,2 R. Sciammas,1,3 X. Li,1,3 W. Chen.1,3

    1Center for Immunobiology & Transplant Science, Houston Methodist Research Institute, Houston, TX; 2Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; 3Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.

    How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…
  • 2018 American Transplant Congress

    LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process

    S. Gibney,1 M. Efre,1 T. Ashry,1 C. Yang,1 T. O'Shea,1,2 R. White,2 P. Russell,1 J. Madsen,1 R. Colvin,2 A. Alessandrini.1,2

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; 2Department of Pathology, Massachusetts General Hospital, Boston, MA.

    Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
  • 2018 American Transplant Congress

    Rapamycin Therapy Impairs Treg Expression of CXCR3 and Limits Treg-Dependent Survival of Vascularized Composite Allotransplants

    H. Xu,1 Z. Chen,2 W. Hancock,3,4 S. Levin,5 Y. Zhang.1

    1Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Medicine School of Shanghai Jiaotong University, Shanghai, China; 2Institute of Immunology, University of Pennsylvania, Philadelphia; 3Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; 4Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; 5Orthopaedic Surgery and Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia.

    Vascularized Composite Allotransplantation (VCA) is a procedure to restore limb function or facial appearance. Rapamycin is used in efforts to preserve host Treg function and…
  • 2018 American Transplant Congress

    T-Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell Generation and Regulatory-T-Cell-Dependent Cardiac Allograft Survival

    N. Chun,1 D. Verghese,1 M. Demir,1 M. Fribourg,3 I. Llaudo,1 E. Medof,4 P. Heeger.1

    1Div of Nephrology, Dept of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, NY, NY; 2Dept of Neurology, Icahn School of Medicine at Mount Sinai, NY, NY; 3Dept of Pathology, Case Western Reserve Univ, Cleveland, OH.

    C5aR2 (C5L2/gp77) is a transmembrane receptor that binds C5a but lacks motifs needed to induce G-protein coupled signal transduction. C5aR2 modulates various inflammatory diseases in…
  • 2018 American Transplant Congress

    T Cell Exhaustion in Kidney Transplant Patients

    M. Fribourg,1 C. Fischman,2 L. Anderson,2 B. Burrell,3 P. Heeger,2 P. Cravedi.2

    1Department of Neurology, Icahn School of Medicine, New York; 2Department of Medicine, Icahn School of Medicine, New York; 3Immune Tolerance Network, Bethesda.

    Background: T cell exhaustion is a dysfunctional state that arises during chronic infection and cancer in response to persistence of high antigenic load. Whether chronic…
  • 2018 American Transplant Congress

    TGF-b Plus Rapamycin Induce Foxp3 and Promote iTreg Development and Suppressive Function, Leading to Long-Term Allograft Survival

    L. Wang, A. Samanta, R. Han, N. Zhou, W. Hancock.

    Path & Lab Med, CHOP & UPenn, Philadelphia, PA.

    Given the major roadblocks to development of Treg-based cell therapy, pharmacologic approaches to expand endogenous Tregs warrant attention, including approaches with more sustained effects than…
  • 2018 American Transplant Congress

    Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model

    C. Gu, F. Liu, J. Yang.

    Plastic and Reconstructive Surgery, Shanghai Ninth Hospital, Shanghai, China.

    Background: Induction of tolerance and minimizing the toxicity of immuno- suppression are two fundamental goals in vascularized composite allotrans- plantation. Accumulating data indicate that triptolide…
  • 2018 American Transplant Congress

    Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival

    P. Porrett,1 J. Cohen,2 R. Xu,1 E. Lewis,3 M. Elovitz,3 E. Wherry,4 D. Sawinski.2

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Medicine, University of Pennsylvania, Philadelphia, PA; 3OBGyn, University of Pennsylvania, Philadelphia, PA; 4Microbiology, University of Pennsylvania, Philadelphia, PA.

    Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…
  • 2018 American Transplant Congress

    Donor Reactive Eomesderminhi CD8+ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection

    A. Perez-Gutierrez,1,2 D. Metes,1 S. Hariharan,1 A. Thomson,1 M. Ezzelarab.1

    1Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA; 2Surgery, Transplantation Institute, University of Chicago, Chicago, IL.

    IntroductionMemory T cell responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the…
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