Articles tagged "T cells"

2018 American Transplant Congress
A 3C Approach Drives Epigenetic Fixation of Foxp3 Expression and Stabilizes Treg Cell Lineage and Therapeutic Function
X. Xiao, X. Zhang, J. Li, S. Chen, P. Lan, Y. Dou, W. Chen, X. Li.
Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX.
The instability of the regulatory T (Treg) cell lineage precludes their therapeutic potential in transplantation and autoimmune diseases. Herein, we invented a novel approach to…
2018 American Transplant Congress
In Vitro α-Galactosylceramide Stimulation Expands CD4⁺CD25⁺Foxp3⁻ Regulatory T Cell Precursors in Murine Thymocytes
H. Katsumata,^1,2 M. Ikemiyagi,¹ T. Kanzawa,¹ H. Fukuda,¹ R. Ishii,¹ K. Saiga,^1,3 M. Okumi,¹ Y. Ishii,⁴ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan; ³Urology, Jyoban Hospital of Tokiwa Foundation, Fukushima, Japan; ⁴Laboratory for Immunotherapy, Center for Integrative Medical Sciences (IMS) RIKEN, Yokohama, Japan.
Background: We previously established mixed chimerism after invariant natural killer T-cell stimulation by administration of liposomal α-galactosylceramide (lipo-αGC) and costimulatory blockade, leading to regulatory T…
2018 American Transplant Congress
TACI Polymorphisms Associated with Allograft Rejection in Mice and in Man
M. Barbosa,¹ E. Farkash,² J. Platt,³ M. Cascalho.³
¹Surgery, University of Michigan, Ann Arbor, MI; ²Pathology, University of Michigan, Ann Arbor, MI; ³Surgery/Microbiology and Immunology, University of Michigan, Ann Arbor, MI.
Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants in healthy individuals. In fact, TACI is…
2018 American Transplant Congress
C5aR Regulates Myeloid Derived Suppressor Cells (MDSCs) in Transplantation
I. Llaudo, J. Ochando, P. Heeger.
Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Prolonged survival of anti-CD154-(MR1)-treated murine heart transplant recipients is dependent on regulatory T cells (Treg) and MDSC. Based on studies in the tumor literature suggesting…
2018 American Transplant Congress
Mechanisms of DEPTOR Function in CD4⁺ T Cell Subsets
J. Wedel,¹ K. Liu,¹ P. Sage,² M. Laplante,³ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston; ²Department of Microbiology and Immunobiology, Harvard Medical School, Boston; ³IUCP, Lavel University, Quebec, Canada.
We have previously observed that the cell intrinsic modulatory protein DEPTOR (DEP) stabilizes Foxp3 expression, enhances Treg function and inhibits Treg dedifferentiation. In vivo, sustained…
2018 American Transplant Congress
Donor T Cells Undermine the Graft-Protective Effect of DST Plus Anti-CD154
M. Iglesias, M. Chicco, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins University, Baltimore, MD.
Costimulation blockade (CoB) regimens are a promising immunomodulatory strategy to prevent transplant rejection. However, their efficacy is affected by multiple factors, including still unknown ones.…
2018 American Transplant Congress
Increase on Regulatory Cells in Kidney Transplanted Patients Presenting Donor-Specific Antibodies
G. Maciel,¹ M. Fernandes,^1,2 E. Barbosa,² H. Rodrigues,¹ N. Panajotopolus,¹ F. Agena,² E. David-Neto,² V. Coelho,¹ M. Castro.²
¹Laboratory of Immunology, São Paulo University, São Paulo, Brazil; ²Renal Transplantation Service, Clinical Hospital, São Paulo, Brazil.
The role of anti-HLA donor specific antibodies (DSA) in increasing the risk of graft rejection is known. Nevertheless, not all patients with DSA develop rejection…
2018 American Transplant Congress
CD4⁺ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN; ²Surgery, University of Colorado Denver, Aurora, CO.
Pancreatic islet allografts are effective for restoring euglycemia in type 1 diabetics (T1D) but are vulnerable to rejection by autoreactive (islet-specific) and/or conventional alloreactive T…
2018 American Transplant Congress
TORC1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
B. Al Dulaijan, S. Eskandari, J. Karnyski, J. Assaker, S. Cai, A. Mansouri, M. Mohamed, J. Azzi.
Transplantation Research Center, BWH, Harvard Medical School, Boston, MA.
The safety and efficacy of adoptive transfer of regulatory T cells (Tregs) are being extensively investigated in ongoing clinical trials. However, these trials have been…
2018 American Transplant Congress
Loss of HIF-1α in CD4 T Cell Improve Outcome of Mouse Vascularized Osteomyocutaneous Allotransplantation under Costimulation Blockade
C-.H. Lin,^1,2 M. Anggelia,^1,2 H. Yang,³ W. Chuang,⁴ H. Cheng,¹ F-.C. Wei,^1,2 G. Brandacher.⁵
¹PRS, Center for VCA, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; ³Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵PRS, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Allograft survival depends on the balance of effector T cells (Teff) and regulatory T cells (Tregs). Previous study suggested that the balance is controlled…