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Articles tagged "T cells"

  • 2020 American Transplant Congress

    Noninvasive Imaging of CD122+ T Cells via Immuno-PET for Detection of Acute Cellular Rejection

    A. J. Matar1, B. P. Lovasik1, D. Vanover2, L. Rotolo2, Y. Dong1, D. A. Faber1, D. V. Mathews1, W. H. Kitchens1, P. Santangelo2, A. B. Adams1

    1Surgery and Transplantation, Emory University, Atlanta, GA, 2Biomedical Engineering, Georgia Tech, Atlanta, GA

    *Purpose: Acute cellular rejection (ACR) remains a clinically important problem following organ transplantation. Clinically, suspicion of ACR is dependent upon serum laboratory values, and diagnosis…
  • 2020 American Transplant Congress

    Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation

    S. Hasgur, R. Fan, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…
  • 2020 American Transplant Congress

    Non-Human Primate B Cells Into Regulatory B Cells by Activation with CpG

    K. Lee1, C. Rickert1, K. Deng1, N. Feeney1, N. Tanimine2, Q. Fu1, G. Huai1, J. Lei1, C. Leguern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Gastroenterological Transplantation Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: We previously generated Toll like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed…
  • 2020 American Transplant Congress

    Utility of dd-cfDNA in TCMR 1A and Borderline Allograft Rejection

    E. Stites1, D. Kumar2, O. Olaitan3, G. Gupta2

    1University of Colorado, Aurora, CA, 2Virginia Commonwealth University, Richmond, VA, 3Rush University, Chicago, CA

    *Purpose: The value of donor-derived cell-free DNA (dd-cfDNA, AlloSure) as a molecular marker for the early diagnosis of mild T-cell mediated rejection (Banff TCMR 1A…
  • 2020 American Transplant Congress

    DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation

    J. Wedel1, M. Maslyar1, S. Kong1, M. Laplante2, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada

    *Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
  • 2020 American Transplant Congress

    High Frequencies of Donor-Derived Memory T and NK Cells in the Blood of Lung Transplant Recipients May Contribute to Protection from Chronic Lung Allograft Dysfunction

    R. Bellmàs Sanz1, A. Hitz1, B. Wiegmann2, K. Bläsing1, F. Ius2, W. Sommer2, J. Kühne1, L. Horn1, A. Knöfel2, I. Tudorache2, A. Haverich2, D. Jonigk3, G. Warnecke2, C. Falk1

    1Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany, 3Institute of Pathology, Hannover Medical School MHH, Hannover, Germany

    *Purpose: After lung transplantation (LuTx), a transient chimerism of donor cells exists in the blood of recipients due to the migration of lymphocytes from the…
  • 2020 American Transplant Congress

    T Follicular Regulatory Cell Deficiency Enhances Secondary T Follicular Helper Cell Responses after Transplantation

    E. S. Crichton, S. Zeng, I. Badell

    Emory University, Atlanta, GA

    *Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
  • 2020 American Transplant Congress

    Influence of Microbial Communities on Transplantation

    K. Janek1, J. Fechner1, K. Krautkramer2, S. Sudakaran3, J. Denu4, J. Handelsman3, F. Rey5, E. Vivas5, J. Mezrich1

    1Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Wisconsin Institute for Discovery, Madison, WI, 4Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 5Bacteriology, University of Wisconsin-Madison, Madison, WI

    *Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
  • 2020 American Transplant Congress

    Challenges in Manufacturing Clinically Competent Regulatory T Cells from Obese Renal Transplant Recipients

    F. Marti, A. Ruffing, E. Chacon, L. Turcios, D. Valvi, J. Gonzalez, R. Gedaly

    Surgery, University of Kentucky, Lexington, KY

    *Purpose: The obesity epidemic has expanded rapidly over the last decade. Our program is developing a novel clinical protocol using expanded autologous regulatory T cell…
  • 2020 American Transplant Congress

    IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance

    M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi

    Plastic Surgery, Johns Hopkins University, Baltimore, MD

    *Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
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