2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…2021 American Transplant Congress
AT-1501, a Novel and Clinically Applicable CD40L Specific Monoclonal Antibody, Promotes Islet Allograft Survival in Nonhuman Primates
*Purpose: Immune intervention with a CD40L specific monoclonal antibody (mAb, Hu5c8, Biogen) has previously been shown to safely and effectively prevent islet allograft (IA) rejection…2021 American Transplant Congress
T-cell-Mediated Immunity to Sars-cov-2 Defines Covid-19 Risk and Severity in Transplanted and Non-Transplanted Individuals and Associates with Myeloid-Derived Suppressor Cells
*Purpose: We assessed whether COVID-19-risk is enhanced by chronic immunosuppression, and is associated with suppressor cells.*Methods: We tested 66 COVID-19 patients, including 26 with solid…2021 American Transplant Congress
Estrogen Receptors Alpha and Beta are Required for Immune Homeostasis and Normal Treg Function
*Purpose: Estrogen signaling is a critical component of mammalian homeostasis, acting through a complex and interconnected system of hormone synthesis pathways and receptor signaling cascades.…2021 American Transplant Congress
Gm2a: A Novel Regulatory Pathway Controlling Alloimmunity
1Department of Surgery, Emory University, Atlanta, GA, 2Mount Sinai School of Medicine, New York, NY
*Purpose: In recently published studies we discovered that the inhibitory receptor FcγRIIB regulates CD8+ T cell alloimmunity in a cell-autonomous fashion, and that increased expression…2021 American Transplant Congress
Proteomic Analysis of Extracellular Vesicles Derived From a Potent Donor-specific Regulatory T Cell-enriched Population Demonstrates Multiple Markers of Immune Suppression
*Purpose: Extracellular vesicles (EVs) are emerging as vital mediators of intercellular communication and immune regulation. Regulatory T cells (Tregs) play an integral role in immune…2021 American Transplant Congress
Single Cell Rna-Sequencing of Urinary Cells and Defining the Immune Landscape of Rejection in Human Kidney Allografts
*Purpose: Transcriptome-based clustering of urinary cells in kidney transplant recipients may help identify cell-type specific injury and develop cell-type specific biomarkers for the noninvasive assessment…2021 American Transplant Congress
Distinct Phenotype and Function of Antibody-suppressor Cxcr5+Cd8+ T Cells
*Purpose: We have reported that the novel subset of antibody-suppressor CD8+ T cells (termed CD8+ TAb-supp cells) require the expression of CXCR5. In addition, alloprimed…2021 American Transplant Congress
The Gut Microbiotainduces Local and Systemic Immune Modulation
*Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…2021 American Transplant Congress
Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation
Department of Surgery, Emory, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
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