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Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model

C. Gu, F. Liu, J. Yang.

Plastic and Reconstructive Surgery, Shanghai Ninth Hospital, Shanghai, China.

Meeting: 2018 American Transplant Congress

Abstract number: B383

Keywords: FK506, Immunosuppression, Rejection, T cells

Session Information

Date: Sunday, June 3, 2018

Session Name: Poster Session B: VCA

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Related Abstracts
  • Non-Myeloablative Conditioning with Low-Dose Total Body Irradiation in Place of Cyclophosphamide Induces Mixed Chimerism and Long-Term Immunosuppression Free Allograft Survival without Acute Kidney Injury in HLA Mismatched Kidney Transplantation
  • Vascularized Composite Allograft Tolerance with Transient High-Dose Tacrolimus Across a Full MHC Mismatch in a Large Animal Model.

Background: Induction of tolerance and minimizing the toxicity of immuno- suppression are two fundamental goals in vascularized composite allotrans- plantation. Accumulating data indicate that triptolide is an agent that may have the capacity to suppress inflammation and immunologic rejection. Methods: A heterotopic hindlimb allotransplantation model from Brown Norway to Lewis rats was established and treated with different doses of tacrolimus com- bined with or without triptolide. Mean survival time of the transplants was moni- tored, and histopathologic examination of the skin was performed. The level of inflammatory cytokine interleukin-1β, interleukin-6, and tumor necrosis factor-á in peripheral blood was assayed. The percentage of T lymphocytes and its subsets was measured using flow cytometry. The level of recipient peripheral chimerism and the apoptosis of donor bone marrow cells were evaluated. The apoptotic related genes bcl-2 and Bax were detected by real-time polymerase chain reaction. Results: The authors' results showed that triptolide not only reduces the dose of tacrolimus required for immunosuppression, but also decreased drug side effects in terms of weight gain and diarrhea. Triptolide had an obvious effect on proinflammatory cytokine expression and T-lymphocyte proliferation in the peripheral blood. Interestingly, triptolide could increase the mixed chimerism level of recipients, possibly by inhibiting the apoptosis of transplanted bone marrow cells by means of regulation of the apoptotic genes bcl-2 and Bax. Conclusions: Triptolide reduces the dose of tacrolimus required for immu- nosuppression by attenuating inflammation and by T-cell suppression. Fur- thermore, triptolide increases the chimerism level, which might contribute to acceptance of the allografts.

CITATION INFORMATION: Gu C., Liu F., Yang J. Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Gu C, Liu F, Yang J. Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model [abstract]. https://atcmeetingabstracts.com/abstract/triptolide-reduces-the-required-dose-of-tacrolimus-by-attenuating-inflammation-enhancing-immunosuppression-and-increasing-donor-chimerism-in-a-heterotopic-hindlimb-transplantation-model/. Accessed February 28, 2021.

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