2022 American Transplant Congress
Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis
*Purpose: Defining the T cell landscape in renal allograft rejection (RAR) transcriptomically at the single cell level remains to be achieved. The purpose of the…2022 American Transplant Congress
Flow Cytometric Pattern of γδ Tcr Expression Identifies Outcomes in Kidney Transplantation
*Purpose: The main challenge with kidney transplantation is the possibility of rejection, classified into two types, antibody-mediated rejection (ABMR) and T cell-mediated rejection (TCMR). The…2022 American Transplant Congress
Tracking of Donor Reactive T Cell Clones Can Be Used to Diagnose or Even Predict Kidney Transplant Rejection
1Northwestern University, Chicago, IL, 2Adaptive Biotechnologies, Seattle, WA
*Purpose: Transplant (Tx) rejection currently requires an invasive biopsy for diagnosis. We have tested if serial quantitation of donor reactive T cell clones (DRTC) can…2022 American Transplant Congress
Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation
Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are vital mediators of intercellular communication, playing an important role in the immune synapse and the T cell response. However, regulatory…2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8+ T Cells That Persist Despite Corticosteroids and ATG Therapy
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…2022 American Transplant Congress
Autencoder, a Novel Computational Tool to Score T Cell Clones Demonstrates Biopsy T Cell Clones Are Not Represented in the Peripheral Blood
Washington University, St Louis, MO
*Purpose: Antibody-mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. The generation and…2022 American Transplant Congress
The Impact of T-Cell Receptor Diversity in Acute Kidney Transplant Rejection
1UCSF, San Francisco, CA, 2Adaptive Biotechnologies, Seattle, WA
*Purpose: Recent developments in T-cell receptor (TCR) immunosequencing allow for analysis of alloreactive human T-cell populations both before and after engraftment. In this study, we…2021 American Transplant Congress
Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring
*Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…2021 American Transplant Congress
Analysis of the Difference of the Monitoring Results of Tcr High Variable Area in Renal Transplant Recipients After Treatment with Different Immune Induction Schemes
The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
*Purpose: To observe and summarize the effect of different induction schemes on the highly variable region of T-lymphocyte receptor (TCR) in living relative renal transplant…2021 American Transplant Congress
The Microenvironment of Belatacept-Resistant Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Belatacept is a co-stimulation blockade immunosuppressant, that despite demonstrating improved long-term outcomes, has not been widely adopted, in part, due to concern over early…
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