Articles tagged "T cell receptors (TcR)"

2018 American Transplant Congress
Altered Function of Cytomegalovirus Specific T Cells in Transplant Recipients
L. Higdon,¹ J. Trofe-Clark,² S. Liu,¹ N. Saligrama,¹ K. Margulies,² M. Davis,¹ J. Maltzman.^1,3
¹Stanford U, Stanford, CA; ²U Pennsylvania, Philadelphia, PA; ³VA Palo Alto, Palo Alto, CA.
Background: Cytomegalovirus (CMV) reactivation is associated with increased morbidity and mortality in transplant recipients. CMV establishes latency for the host's lifetime and frequently reactivates. Immunosuppression,…
2018 American Transplant Congress
Identifying Specificity Groups in the CMV IE-1 T Cell Receptor Repertoire
M. Lucia,¹ F. Rubelt,² S. Luque,³ S. Krams,¹ C. Esquivel,¹ O. Bestard,³ O. Martinez.¹
¹Department of Surgery, Stanford University, Palo Alto; ²Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto; ³Experimental Nephrology, IDIBELL, Barcelona, Catalonia, Spain.
Cytomegalovirus (CMV) continues to be a major problem for organ transplant recipients. T cells specific to the CMV antigens immediate-early (IE-1) and pp65 CMV govern…
2018 American Transplant Congress
TLR2 with TCR Signaling Mobilizes Treg Lymphatic Migration
W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.
UMB, MD.
Background: Regulatory T cells (Treg) express high levels of lymphotoxin (LT) and bind the LT receptor (LTβR) on lymphatic endothelial cells (LEC). This receptor-ligand interaction…
2017 American Transplant Congress
Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).
Z. Lyu,¹ L. Pang,¹ G. Zeng,² Y. Huang,² P. Randhawa.²
¹Pathology & Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…
2017 American Transplant Congress
Contribution of γδ T-Cell Subsets and IL-17A Release to Ischemia Reperfusion Injury (IRI) and Kidney Allograft Rejection in Mice.
A. Thorenz,¹ S. Rong,¹ N. Völker,¹ R. Chen,¹ J. Bräsen,² H. Haller,¹ C. Klemann,³ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, Hannover Medical School, Hannover, Germany; ³Pediatric Surgery, Hannover Medical School, Hannover, Germany
Ischemia reperfusion injury (IRI) contributes to acute allograft injury and to delayed graft function (DGF) which is a trigger for acute rejection after kidney transplantation…
2017 American Transplant Congress
Evaluation of Function and TCR signaling Profile of CD57⁺ T Cells in Allo-Specific Immunity.
H. Xu,¹ T. Brennan,¹ Q. Li,² A. Kirk.¹
¹Department of Surgery, Duke University School of Medicine, Durham, NC; ²Department of Immunology, Duke University School of Medicine, Durham, NC
Our studies have showed that CD57+ cells are resistant to B7 costimulation blockade (CoB). We hypothesize that CD57+ cells are highly sensitive to T cell…
2017 American Transplant Congress
BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.
U. Stervbo,^1,2 M. Nienen,¹ B. Weist,² P. Wehler,² T. Westhoff,¹ H.-D. Volk,² P. Reinke,² N. Babel.^1,2
¹Center for Translational Medicine, Medical Clinic I, Marienhospital Herne, University Hospital of the Ruhr-University Bochum, Bochum, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charité – University Medicine, Berlin, Germany
Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression…
2017 American Transplant Congress
Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.
T. Win,¹ N. Murakami,² I. Avraham-Davidi,¹ J. Teague,¹ E. Lowry,¹ R. Lopdrup,¹ E. Bueno,¹ A. Chandraker,¹ L. Riella,¹ B. Pomahac,¹ R. Clark.¹
¹Brigham and Women's Hospital, Boston; ²Broad Institute of MIT and Harvard, Cambridge
BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…
2017 American Transplant Congress
In Depth Characterization of Ex Vivo Expanded Polyclonal Regulatory T Cells Used in a Phase I Clinical Trial Following Kidney Transplantation.
J. Heinrichs,¹ J. Mathew,^1,2 I. Konieczna,¹ J. He,¹ X. Haung,¹ A. LeFever,¹ J. Leventhal.¹
¹Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL; ²Microbiology and Immunology, Northwestern University, Chicago, IL
Initial clinical trials have investigated the safety of regulatory T cells (Tregs) as a therapy during aberrant immune activation, like graft-versus-host disease (GVHD) following stem…
2016 American Transplant Congress
Clonal Expansion of Donor-Specific Tregs Following Combined Kidney and Bone Marrow Transplantation.
T. Savage,¹ S. Dewolf,¹ A. Obradovic,¹ S. Lau,¹ J. Zuber,¹ L. Turka,^2,3 Y. Shen,¹ M. Sykes.¹
¹Columbia University, New York; ²Massachusetts General Hospital, Boston; ³Immune Tolerance Network, Boston.
HLA-mismatched allograft tolerance was intentionally induced via combined kidney and bone marrow transplant (CKBMT) in two ITN protocols (NKDO3 and ITN036ST), but the mechanisms of…