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American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2020 American Transplant Congress

    Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation

    J. Wu

    Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
  • 2020 American Transplant Congress

    T Cell Hyporesponsiveness in Kidney Transplant Recipients is Associated with Urinary Tract Infections and Age of Kidney Transplant: Implications for Allograft Nephropathy

    A. Assounga, S. Omarjee

    Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa

    *Purpose: Chronic allograft nephropathy is the main cause of kidney graft loss. With the use of potent immunosuppressive treatments, acute rejections are less and less…
  • 2020 American Transplant Congress

    Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

    A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. A. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
  • 2020 American Transplant Congress

    Efficacy of Photobiomodulation Therapy Combined with Short-Term Immunosuppressants Prolonged Allotransplant Survival in a Rodent Hind-Limb Model

    Y. Kuo1, C. Chen2, R. Chen2, Y. Li2

    1Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, 2Division of Plastic Surgery, Department of Surgery,, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    *Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…
  • 2019 American Transplant Congress

    PD-1+CD3+CD4-CD8- (Double Negative T-cells) Are Early Responders during Kidney Ischemia Reperfusion Injury and Regulated by Non-Classical MHC Molecules

    M. Sadasivam, S. Noel, S. Lee, J. Gong, A. Hamad, H. Rabb

    Johns Hopkins University and School of Medicine, Baltimore, MD

    *Purpose: Unconventional T-cells (e.g. Tregs and γδT-cells) are increasingly recognized for their roles in maintaining homeostasis and protecting non-lymphoid tissues against injury/stress. Double negative (DN)…
  • 2019 American Transplant Congress

    Application of Small Molecule Fluorescent Probes in Early Activation Imaging of CD8+ T Lymphocytes

    P. Rong, X. Zhou

    Central South University, The Third Xiangya Hospital, Changsha, China

    *Purpose: As a subset of T lymphocytes, CD8+ T lymphocytes play a vital role in the body's immune system.CD8+ T lymphocytes are responsible for the…
  • 2019 American Transplant Congress

    How and Why Dyrk1a is Required for Optimal Foxp3+ Treg Functions

    W. W. Hancock, N. Zhou, R. Han, L. Wang

    Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: TCR-induced calcineurin phosphatase activation and subsequent Nfat dephosphorylation, leading to Nfat translocation to the nucleus, is a key event in conventional T cell activation.…
  • 2019 American Transplant Congress

    Characterization of Circulating T-cell Specific Exosomes during Acute Rejection in Murine Heart Transplantation Model

    R. Hu1, V. Korutla1, L. Korutla1, S. Rostami1, A. Habertheuer1, S. Addya2, J. Harmon1, P. Zielinski1, S. Reddy1, A. Freas1, C. Ram1, A. Naji1, P. Vallabhajosyula1

    1Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 2Thomas Jefferson University, Philadelphia, PA

    *Purpose: Exosomes are nanoparticles (30-200nm) released by many cell types. They carry nucleic acid and proteins that may reflect conditional changes in their tissue counterparts.…
  • 2019 American Transplant Congress

    The mIR17-92 Cluster Promotes Costimulation Resistant Effector Memory T Cell-Mediated Alloresponses

    H. Xu1, Q. Guo1, M. Song1, A. Miler1, Q. Li2, A. Kirk1

    1Surgery, Duke University, Durham, NC, 2Immunology, Duke University, Durham, NC

    *Purpose: CD57 expression has been shown to identify a subset of memory T cells that are resistant to CD28/B7 costimulation blockade (B7CoB). This study was…
  • 2019 American Transplant Congress

    Immunobiogram, a New IVD Immunoassay to Test the Sensitivity Profile of Kidney Transplant Recipients to Immunosuppressive Drugs: Further Results from BH-Pilot Study

    C. Jimenez1, J. M. Portoles2, D. Blánquez3, L. Arribas3, A. Ortega4, T. Diez5, I. Portero6

    1Nephrology Department, La Paz Hospital, Madrid, Spain, 2Nephrology Department, Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, 3Adamas Engineering Consulting, Madrid, Spain, 4I+D, Biohope, Madrid, Spain, 5Medical, Biohope, Madrid, Spain, 6CEO, Biohope, Madrid, Spain

    *Purpose: IMBG is an immunoassay developed by Biohope to measure in vitro PBMC sensitivity/resistance profile to a panel of immunosuppressive drugs (IS) in Kidney Transplant…
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