2015 American Transplant Congress
Tissue Engineering Human Kidneys for Costimulation Blockade
1BREONICS, Inc., Watervliet, NY; 2Surgery, University of Utrecht, Utrecht, Netherlands.
Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…2015 American Transplant Congress
Repurposing Jak/STAT Signaling Inhibition to Enhance Costimulation Blockade and Promote Transplant Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore.
PURPOSE: Transplant tolerance induction through conventional costimulation blockade (CoB) remains an elusive goal. Recent evidence suggests that inflammatory cytokines contribute to the activation of alloreactive…2015 American Transplant Congress
Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation
We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…2015 American Transplant Congress
BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses
Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…2015 American Transplant Congress
Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation
Background: The interspecies incompatibility of CD47 is an important mechanism triggering rejection of cellular xenografts, including both hematopoietic and non-hematopoietic cells, by recipient macrophages. Our…2015 American Transplant Congress
CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…2015 American Transplant Congress
Assessment of Viral-Specific Memory T Cell Responses and Infection Rates in HLA-Sensitized (HS) Kidney Transplant Patients (Tx Pts) Treated With Everolimus & Low-Dose Tacrolimus (Eve/Tac)
Transplant Immunology & Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles.
Background: mTOR inhibitors stimulate viral-specific memory CD8+ T cell differentiation and increase viral clearance in infected Tx pts. HS pts desensitized (DES) with IVIG +…2015 American Transplant Congress
Th-17 Alloimune Responses in Renal Allograft Biopsies from Recipients of Kidney Transplants Using Extended Criteria Donors During Acute T-Cell Mediated Rejection
Although renal transplantation using expanded criteria donors has become a common practice, immune responses related to immunosenescence in those kidney allografts have not been studied…2015 American Transplant Congress
Allo-Stimulated Interferon-γ Release and Natural Killer Cell Function Defines and Risk Stratifies Cancer Development in Kidney Transplant Recipients Who Have Cancer Post-transplantation
Reducing immunosuppression is efficacious in primary prevention of cancer in Kidney Transplant Recipients (KTR) but can precipitate graft rejection. Conventional immunosuppressive drug monitoring fails to…2015 American Transplant Congress
Interleukin-1 Receptor Signaling by Graft Stromal Cells Regulates Donor-Reactive CD8 T Cell Responses to Cardiac Allografts
Allograft reperfusion induces inflammation that directs the infiltration of memory T cells into the allograft and their activation to express functions mediating graft injury. The…
American Transplant Congress abstracts