ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2022 American Transplant Congress

    Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, B. Lonze1, E. Weldon1, Z. Stewart1, C. DiMaggio1, J. Allen3, S. Gray-Gaillard3, S. Solis3, M. Tuen3, J. Leonard1, R. Montgomery1, R. Herati3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3NYU Langone Health, New York, NY

    *Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
  • 2022 American Transplant Congress

    Assessment of Humoral and Cellular Immune Responses to Sars Cov-2 Vaccination in Immunocompromised Renal Allograft Recipients

    B. Shin, R. Zhang, T. M. Gadsden, A. Petrosyan, A. Vo, N. Ammerman, S. Sethi, E. Huang, A. Peng, R. Najjar, J. Atienza, I. Kim, S. C. Jordan

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: SARS CoV-2 vaccination elicits both robust humoral and T-cell immune responses in healthy individuals. However, a comprehensive assessment of immune responses to SARS-CoV-2 vaccination…
  • 2022 American Transplant Congress

    Novel Immune Checkpoint Molecule TIGIT Mediates Experimental Kidney Ischemia Reperfusion Injury

    S. Noel, K. Lee, S. Gharaie, J. T. Kurzhagen, H. Rabb

    Medicine, Johns Hopkins University, Baltimore, MD

    *Purpose: T cells play both pathogenic and reparative roles in kidney ischemia reperfusion injury (IRI) but the molecular mechanisms regulating kidney T cell functions are…
  • 2022 American Transplant Congress

    Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival

    J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
  • 2022 American Transplant Congress

    T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism

    T. J. Borges1, N. Murakami2, I. T. Lape1, R. B. Gassen1, K. Liu1, L. V. Riella1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…
  • 2022 American Transplant Congress

    Optimal Development and Effector Function of Antibody-Suppressor CXCR5+CD8+ T Cells Requires Host IFN-γ and CD4+ T Cells

    J. Zimmerer, S. Chaudhari, M. Hart, J. Han, K. Koneru, G. Bumgardner

    OSUWMC, Columbus, OH

    *Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…
  • 2022 American Transplant Congress

    Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation

    G. Huang1, H. Zhang1, X. Chen1, G. Zhao1, J. Luo1, S. Yang2, J. Qiu1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 2Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    *Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…
  • 2022 American Transplant Congress

    The Role of T Lymphocyte Subsets in Kidney Transplantation

    L. Vagiotas1, A. Xochelli2, E. Sampani3, V. Nikolaidou2, D. Asouchidou2, E. Kasimatis3, N. Antoniadis1, M. Daoudaki4, M. Stangou3, A. Papagianni3, G. Tsoulfas1, A. Fylaktou2

    1Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 2National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, 3Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, 4Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece

    *Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
  • 2022 American Transplant Congress

    TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival

    S. Miura1, Z. Abady1, F. Pollok1, M. Ma1, K. Kinoshita1, S. Fogarty2, P. Maguire2, B. Daugherty2, S. Lederman2, R. Pierson III1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, 2Tonix Pharmaceuticals, Chatham, NJ

    *Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…
  • 2022 American Transplant Congress

    CD8+ T Cells Differentiate into a CD43-expressing Effector Population After Transplantation

    G. Cohen, M. A. Kallarakal, S. M. Krummey

    Department of Pathology, Johns Hopkins University, Baltimore, MD

    *Purpose: Despite a significantly reduced toxicity profile and improved long-term graft function versus calcineurin inhibitors, widespread adaptation of belatacept (CTLA-4 Ig) has been limited due…
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