2022 American Transplant Congress
Optimal Development and Effector Function of Antibody-Suppressor CXCR5+CD8+ T Cells Requires Host IFN-γ and CD4+ T Cells
*Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…2022 American Transplant Congress
Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation
*Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…2022 American Transplant Congress
TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival
*Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…2022 American Transplant Congress
CD8+ T Cells Differentiate into a CD43-expressing Effector Population After Transplantation
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: Despite a significantly reduced toxicity profile and improved long-term graft function versus calcineurin inhibitors, widespread adaptation of belatacept (CTLA-4 Ig) has been limited due…2022 American Transplant Congress
Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells
1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD
*Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…2022 American Transplant Congress
MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation
Duke University School of Medicine, Durham, NC
*Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…2022 American Transplant Congress
Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…2022 American Transplant Congress
PSGL-1-mTOR-TIM3 Signaling in a Murine Model of Hindlimb Transplantation
*Purpose: Peri-transplant tissue damage driven by innate-adaptive immune cascades resulting from ischemia-reperfusion injury (IRI) is a major concern in vascularized composite allotransplantation (VCA). Here, we…2022 American Transplant Congress
Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression
1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX
*Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
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