ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "T cell activation"

  • 2022 American Transplant Congress

    TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival

    S. Miura1, Z. Abady1, F. Pollok1, M. Ma1, K. Kinoshita1, S. Fogarty2, P. Maguire2, B. Daugherty2, S. Lederman2, R. Pierson III1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, 2Tonix Pharmaceuticals, Chatham, NJ

    *Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…
  • 2022 American Transplant Congress

    CD8+ T Cells Differentiate into a CD43-expressing Effector Population After Transplantation

    G. Cohen, M. A. Kallarakal, S. M. Krummey

    Department of Pathology, Johns Hopkins University, Baltimore, MD

    *Purpose: Despite a significantly reduced toxicity profile and improved long-term graft function versus calcineurin inhibitors, widespread adaptation of belatacept (CTLA-4 Ig) has been limited due…
  • 2022 American Transplant Congress

    Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells

    J. Zhao1, S. Jung1, X. Li1, H. Zhang1, S. Movahedi1, V. Kasinath1, M. Uehara1, J. Azzi1, P. Sage1, S. Tullius1, J. S. Bromberg2, R. Abdi1

    1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…
  • 2022 American Transplant Congress

    MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation

    H. Xu, L. Wang, V. A. Bendersky, Q. Gao, Q. Li, A. D. Kirk, H. Xu

    Duke University School of Medicine, Durham, NC

    *Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…
  • 2022 American Transplant Congress

    Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection

    E. H. Koritzinsky, D. Ueda, H. Tsuda, S. Miyari, R. L. Fairchild

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…
  • 2022 American Transplant Congress

    PSGL-1-mTOR-TIM3 Signaling in a Murine Model of Hindlimb Transplantation

    K. Kadono1, F. Messner2, J. He2, Y. Guo2, B. Oh2, G. Brandacher2, J. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Peri-transplant tissue damage driven by innate-adaptive immune cascades resulting from ischemia-reperfusion injury (IRI) is a major concern in vascularized composite allotransplantation (VCA). Here, we…
  • 2022 American Transplant Congress

    Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression

    J. Mattke1, M. Plunk1, R. R. Kane1, B. Naziruddin2

    1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX

    *Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
  • 2022 American Transplant Congress

    A Low Immuknow Level but Behold….pAMR1(H+) Rejection

    M. W. Weston

    Tampa General Hospital, Tampa, FL

    *Purpose: PURPOSE: The purpose of this study is to evaluate the mechanism of pAMR1(H+) rejection in heart transplant recipients with low ImmuKnow levels (ATP
  • 2022 American Transplant Congress

    Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, B. Lonze1, E. Weldon1, Z. Stewart1, C. DiMaggio1, J. Allen3, S. Gray-Gaillard3, S. Solis3, M. Tuen3, J. Leonard1, R. Montgomery1, R. Herati3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3NYU Langone Health, New York, NY

    *Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
  • 2022 American Transplant Congress

    Assessment of Humoral and Cellular Immune Responses to Sars Cov-2 Vaccination in Immunocompromised Renal Allograft Recipients

    B. Shin, R. Zhang, T. M. Gadsden, A. Petrosyan, A. Vo, N. Ammerman, S. Sethi, E. Huang, A. Peng, R. Najjar, J. Atienza, I. Kim, S. C. Jordan

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: SARS CoV-2 vaccination elicits both robust humoral and T-cell immune responses in healthy individuals. However, a comprehensive assessment of immune responses to SARS-CoV-2 vaccination…
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