2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…2019 American Transplant Congress
Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model
Department of Surgery, University of Maryland, Baltimore 21201, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…2019 American Transplant Congress
Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation
*Purpose: This study was designed to investigate the combination of CD40 silencing or MSC infusion with suboptimal doses of Cyclosporine in this renal allograft model.*Methods:…2019 American Transplant Congress
Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation
*Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…2018 American Transplant Congress
Durable Donor Hematopoetic Stem Cell (HSC) Chimerism is Associated with Protection from Native Renal Disease Recurrence in Recipients of Combined HSC/Kidney Transplants
1Northwestern U, Chicago; 2U Louisville, Louisville.
Recurrence of the original cause of ESRD has been observed in trials of tolerance induction for kidney transplantation (KTx) where donor HSC have been used…2018 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine Model
PURPOSE:Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by chronic immunosuppression and rejection. Current clinical tolerance protocols rely on recipient conditioning and…2018 American Transplant Congress
Characterization of Mesenchymal Stem Cell Phenotype and Its Immunomodulatory Effects during Allo-Specific T Cell Immune-Responses
Department of Surgery, Duke University Medical Center, Durham, NC.
Mesenchymal stem cells (MSCs) have been suggested play an important role in modulating cell-mediated immunity. In the setting of transplantation, allogeneic MSCs could mediate suppressive…2018 American Transplant Congress
Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy
PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…
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