Articles tagged "Stem cells"

2019 American Transplant Congress
Human Neutrophil Function against Pathogens in Solid Organ and Stem Cell Transplant Recipients
N. Barros, N. Alexander, Z. Dagher, S. Knooihuizen, A. Viens, A. R. Hopke, D. Irimia, M. K. Mansour
Transplant Infectious Diseases, Massachusetts General Hospital, Boston, MA
*Purpose: The effects of solid organ (SOT) and allogeneic stem cell transplantation (SCT) on the neutrophil function is not well described. In this study, we…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
J. Fair¹, N. Liu¹, S. G. Widen², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
2019 American Transplant Congress
Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation
J. Fair¹, M. M. Shoja¹, N. Liu¹, I. Patrikeev², M. Motamedi², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
2019 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2A Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski¹, H. Atkins², A. Clement², D. Grant¹, C. Bredsen², E. Renner¹, J. Zhang¹, M. Epstein¹, L. Lilly¹, N. Selzner¹, O. Adeyi¹, R. Smith¹, S. Moshkelgosha¹, A. Humar¹, S. Juvet¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Ottawa Hospital Research Institute, Ottawa, ON, Canada
*Purpose: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2019 American Transplant Congress
Generation of Thymic Epithelial Cells from Induced Pluripotent Stem Cells to Prolong Allograft Survival
R. Otsuka, H. Wada, H. Tsuji, A. Sasaki, T. Murata, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
*Purpose: Pluripotent stem cell (PSC) is a potential source of generating functional therapeutic cells for transplantation. Embryonic stem cells are of absolutely allogeneic origin. Induced…
2018 American Transplant Congress
Clinical Application of Mesenchymal Stromal Cells with a Simplified Protocol for ABO Incompatible Liver Transplantation in Severe Hepatic Failure Patients
Y. Zhang,^1,2 J. Zheng,^1,2 J. Cai,^1,2 J. Zhang,^1,2 K. Zeng,^1,2 J. Yao,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Objective The purpose of this study was to test the safety and efficacy of mesenchymal stromal cells (MSCs) treatment with a simplified protocol for ABO…
2018 American Transplant Congress
Autologous Adipose-Derived Stem Cells with In Vivo Immunomodulatory Properties Can Be Generated in Allograft Recipients under Immunosuppression
A. Sicard,¹ J. Rodriguez,² P. Petruzzo,³ J. Kanitakis,⁴ O. Damour,² L. Badet,⁵ A. Gazarian,⁶ F. Buron,¹ O. Thaunat,¹ K. Tarte,⁷ C. Mesnard,⁷ C. Auxenfans,² E. Morelon.¹
¹Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, Lyon, France; ²Cells and Tissue Bank, Edouard Herriot Hospital, Lyon, France; ³University of Cagliari, Cagliari, Italy; ⁴Department of Dermatology, Edouard Herriot Hospital, Lyon, France; ⁵Department of Urology and Transplantation, Edouard Herriot Hospital, Lyon, France; ⁶Clinique du Parc, Lyon, France; ⁷University Hospital of Rennes, Rennes, France.
PurposeTo determine if it is possible to generate mesenchymal stem cells (MSC) with potent in vivo immunomodulatory properties in allograft recipients under immunosuppression, we analyzed…
2018 American Transplant Congress
Robust Hematopoietic Mixed Chimerism and Donor-Specific Skin Allograft Tolerance after Non-Genotoxic Anti-CD117 Immunotoxin Conditioning and Donor Bone Marrow Allotransplantation
Z. Li,¹ A. Czechowicz,^2,3,4,5,6,7 A. Scheck,^2,3,4,5,6 D. Rossi,^3,4,5,6 P. Murphy.¹
¹Lab of Molecular Immunology (LMI), NIAID, Bethesda; ²Dept Pediatrics, Div Stem Cell Transplantation and Regenerative Med, Stanford Univ, Stanford; ³Pgram Cellular & Molecular Med, Div Hematology/Oncology, Boston Children's Hosp, Boston; ⁴Dept Stem Cell & Regenerative Biol, Harvard Univ, Boston; ⁵Dept Pediatrics, Harvard Med Sch, Boston; ⁶Harvard Stem Cell Inst, Harvard Univ, Cambridge; ⁷Dept Pediatric Oncology, Dana Farber Cancer Inst, Boston.
Establishing hematopoietic chimerism enables donor-specific allograft tolerance; however, chimerism protocols typically require either genotoxic conditioning or mega-doses of donor bone marrow cells (BMC), impeding clinical…
2018 American Transplant Congress
PGE2/Beta-Catenin/XBP1 Signaling Controls Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury
C. Li, S. Yue, L. Jiang, Q. Zhu, D. Farmer, R. Busuttil, J. Kupiec-Weglinski, B. Ke.
The Dumont-UCLA Transplant Center, Department of Surgery, Los Angeles, CA.
Background: Mesenchymal stem cells (MSCs) display profound immunomodulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown how MSCs may affect immunity…

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