Articles tagged "Stem cells"

2019 American Transplant Congress
Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation
J. Guiteras¹, L. De Ramon¹, N. Bolaños¹, M. Franquesa², M. Gomà³, J. Cruzado⁴, N. Lloberas¹, J. Grinyó⁴, J. Torras⁴
¹IDIBELL, Hospitalet de Llobregat, Spain, ²IGTP, Badalona, Spain, ³Bellvitge Hospital, Hospitalet de Llobregat, Spain, ⁴Bellvitge Hospital / IDIBELL, Hospitalet de Llobregat, Spain
*Purpose: This study was designed to investigate the combination of CD40 silencing or MSC infusion with suboptimal doses of Cyclosporine in this renal allograft model.*Methods:…
2019 American Transplant Congress
Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation
J. Weiss¹, C. Phillips¹, E. Malin¹, V. Gorantla², S. K. Salgar³
¹Surgery, Madigan Army Medical Center, Tacoma, WA, ²Surgery, Wake Forest University, Salem, NC, ³Clinical Investigation, Madigan Army Medical Center, Tacoma, WA
*Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…
2019 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model
B. Swearingen¹, S. Graves², R. Storb², D. W. Mathes¹
¹University of Colorado School of Medicine, Aurora, CO, ²Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
2019 American Transplant Congress
Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy
R. Pengfei, X. Yuzhi
The Third Xiang Ya Hospital,Central South University, ChangSha, China
*Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…
2019 American Transplant Congress
Human Neutrophil Function against Pathogens in Solid Organ and Stem Cell Transplant Recipients
N. Barros, N. Alexander, Z. Dagher, S. Knooihuizen, A. Viens, A. R. Hopke, D. Irimia, M. K. Mansour
Transplant Infectious Diseases, Massachusetts General Hospital, Boston, MA
*Purpose: The effects of solid organ (SOT) and allogeneic stem cell transplantation (SCT) on the neutrophil function is not well described. In this study, we…
2018 American Transplant Congress
Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells on Hepatocytes Proliferation after Small-for-Size Liver Transplantation via RHO/ROCK Pathway
L. Chen, J. Zheng, J. Cai, J. Yao, K. Zeng, Y. Zhang, Y. Yang.
Department of Liver Transplantation, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Exosomes from umbilical cords-derived mesenchymal stem cells (UC-MSCs-Ex) have been recognized as their ability to promote tissue regeneration in many animal models. However, the in…
2018 American Transplant Congress
Extracellular Vesicles Derived from Huc-MSCs Alleviate Rat Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Neutrophil Inflammatory Response
J. Yao,^1,2 J. Cai,^1,2 J. Zheng,^1,2 L. Chen,^1,2 Y. Zhang,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Mesenchymal stem cells (MSCs) have been reported possessing therapeutic effects on immunoregulation, tissue repair and regeneration from bench to bedside. Extracellular vesicles (EVs) derived from…
2018 American Transplant Congress
Allogeneic Mesenchymal Stem Cells as Induction Therapy Are Safe and Feasible in Renal Allografts: Pilot Results of a Multicenter Randomized Controlled Trial
Q. Sun,¹ F. Han,¹ M. Zhao,² R. Cao,³ D. Zhao,¹ Z. Huang,¹ L. Hong,¹ Y. Peng,¹ Q. Sun.¹
¹Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Zhujiang Hospital, Southern Medical University, Guangzhou, China; ³Second Affiliated Hospital, Guangzhou Traditional Chinese Medicine University, Guangzhou, China.
Background: Delayed graft function (DGF) and acute rejection lead to adverse effects on graft outcomes. Optimal induction intervention should include both renal structure injury repair…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…

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