2018 American Transplant Congress
Curative Correction of FAH Deficiency by Chimeric Stem Cells Transplantation
Fumarylacetoacetate hydrolase (FAH) deficient pigs have been proposed as surrogate hosts for large scale in vivo expansion of normal FAH+ hepatocytes. However, immunologic rejection prevents…2018 American Transplant Congress
Umbilical Cords-Derived Mesenchymal Stem Cells Ameliorates Hepatic Ischemia-Reperfusion Injury via Activating the AMPK-mTOR/ULK1 Signaling Pathway Enhanced Autophagy
UC-MSCs induction of anti-apoptosis has been indicated to play protective roles in liver ischemia-reperfusion (I/R) model. However, the exact molecular mechanisms of UC-MSCs in hepatic…2018 American Transplant Congress
Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model
Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…2017 American Transplant Congress
The Role of Natural Killer Cells in Recognition and Killing of Stem Cells and Stem Cell-Derived Hepatoblasts.
Surgery, Stanford University School of Medicine, Stanford, CA
The generation of stem cell-derived hepatocytes holds promise as a cell-based treatment for liver disease. However, the immune response to stem cell-derived grafts is poorly…2017 American Transplant Congress
Induced Pluripotent Stem Cell (iPS) Derived Schwann Cells to Enhance Functional Recovery Following Nerve Injury and Limb Allotransplantation.
Background Stem cell therapies have provided new aspects for functional recovery. A novel cell-based approach utilizing human induced Pluripotent Stem Cell-derived Schwann Cells (iPSC-SCs) supported…2017 American Transplant Congress
Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.
Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…2017 American Transplant Congress
Impact of Culture Expansion and Inflammatory Cytokine Challenge on DNA Methylation Profiles in MSC.
Mesenchymal stromal cells (MSC) are studied as possible immunotherapy after solid organ transplantation. However, to obtain sufficient numbers, cells need to be expanded in culture.…2017 American Transplant Congress
Mesenchymal Stem Cells Suppress T Cell Proliferation and Improve Allograft Survival in a Nonhuman Primate Transplant Model.
Emory Transplant Center, Emory University, Atlanta, GA
Background: The clinical implementation of costimulation blockade (CoB) provides long-term benefit to transplant recipients, with the short-term drawback of increased acute rejection. Cellular therapies are…2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…2017 American Transplant Congress
Optimization of Pancreatic Islet-Like Clusters from hiPSCs for Cell Therapy in Type 1 Diabetes.
Surgery, Beth Israel Deaconess Medical Center, Boston, MA
IntroductionTreatment for Type 1 Diabetes (T1D) includes pancreas or islets of Langerhans transplantation. Pancreatic beta-like cells from differentiated human induced pluripotent stem cells (hiPSCs) offer…
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