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American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2019 American Transplant Congress

    Human Urine-Derived Stem Cells Protect against Renal Ischemia Reperfusion Injury via Releasing Exosomal miR-146a-5p Which Targets IRAK1 in a Rat Model

    X. Li, Z. Bi, Q. Su, H. Huang, L. Liu, C. Wang

    Organ Transplant Center, Sun Yat-sen University, Guangzhou, China

    *Purpose: Severe ischemia reperfusion injury (IRI) causes delayed graft function and impaires renal allograft survival. Human urine-derived stem cells (hUSCs) is a new source of…
  • 2019 American Transplant Congress

    Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

    N. P. Llore1, J. Stern1, G. Pierre1, E. Lopes1, D. Ekanayake-Alper1, P. Alonso-Guallart1, K. Bruestle1, H. Sakai1, D. Ayares2, M. Lorber2, R. Hawley1, D. H. Sachs1, M. Sykes1, A. D. Griesemer1

    1Columbia Center for Translational Immunology, New York, NY, 2United Therapeutics, Silver Springs, MD

    *Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
  • 2019 American Transplant Congress

    Lineage Tracing Identifies C-­Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases

    E. B. Rangel1, E. Higuti-Sousa1, G. Goss2, B. Goldstein2, B. Seidler3, D. Saur3, S. A Gomes4, J. M. Hare2

    1Albert Einstein Hospital, São Paulo, Brazil, 2University of Miami, Miami, FL, 3Medizinische Klinik, Technische Universität München, Munich, Germany, 4University of São Paulo, São Paulo, Brazil

    *Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…
  • 2019 American Transplant Congress

    Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies­

    W. S. Fagg1, N. Liu1, M. Shoja1, I. Patrikeev2, M. Motamedi2, J. Fair1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX

    *Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
  • 2019 American Transplant Congress

    Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, M. Y. Arfat, C. Ambastha, D. Morales, F. Xuebin, G. J. Bittle, D. Li, S. Kaushal

    Department of Surgery, University of Maryland, Baltimore 21201, MD

    *Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…
  • 2019 American Transplant Congress

    Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation

    J. Guiteras1, L. De Ramon1, N. Bolaños1, M. Franquesa2, M. Gomà3, J. Cruzado4, N. Lloberas1, J. Grinyó4, J. Torras4

    1IDIBELL, Hospitalet de Llobregat, Spain, 2IGTP, Badalona, Spain, 3Bellvitge Hospital, Hospitalet de Llobregat, Spain, 4Bellvitge Hospital / IDIBELL, Hospitalet de Llobregat, Spain

    *Purpose: This study was designed to investigate the combination of CD40 silencing or MSC infusion with suboptimal doses of Cyclosporine in this renal allograft model.*Methods:…
  • 2019 American Transplant Congress

    Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation

    J. Weiss1, C. Phillips1, E. Malin1, V. Gorantla2, S. K. Salgar3

    1Surgery, Madigan Army Medical Center, Tacoma, WA, 2Surgery, Wake Forest University, Salem, NC, 3Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…
  • 2019 American Transplant Congress

    AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model

    B. Swearingen1, S. Graves2, R. Storb2, D. W. Mathes1

    1University of Colorado School of Medicine, Aurora, CO, 2Fred Hutchinson Cancer Research Center, Seattle, WA

    *Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
  • 2019 American Transplant Congress

    Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats

    W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
  • 2019 American Transplant Congress

    Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy

    R. Pengfei, X. Yuzhi

    The Third Xiang Ya Hospital,Central South University, ChangSha, China

    *Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…
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