2019 American Transplant Congress
Human Urine-Derived Stem Cells Protect against Renal Ischemia Reperfusion Injury via Releasing Exosomal miR-146a-5p Which Targets IRAK1 in a Rat Model
Organ Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Severe ischemia reperfusion injury (IRI) causes delayed graft function and impaires renal allograft survival. Human urine-derived stem cells (hUSCs) is a new source of…2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…2019 American Transplant Congress
Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model
Department of Surgery, University of Maryland, Baltimore 21201, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…2019 American Transplant Congress
Dual Treatment of CD40 Silencing or Mesenchymal Stem Cells Infusion with Sub-Therapeutic Doses of Cyclosporine Effectively Prevents Acute Rejection in an Allogenic Model of Renal Transplantation
*Purpose: This study was designed to investigate the combination of CD40 silencing or MSC infusion with suboptimal doses of Cyclosporine in this renal allograft model.*Methods:…2019 American Transplant Congress
Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation
*Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…2019 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model
*Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…2019 American Transplant Congress
Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy
The Third Xiang Ya Hospital,Central South University, ChangSha, China
*Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…
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