2017 American Transplant Congress
The Delivery of Stem Cell Therapy to Extended Criteria Donor Human Livers Using Normothermic Machine Perfusion.
Normothermic machine perfusion of the liver (NMP-L) has been used for organ preservation and viability testing of donor livers. Although previously proposed, delivery of cellular…2017 American Transplant Congress
Effect of Bone Marrow Derived Mesenchymal Stem Cells on Renal Ischemia-Reperfusion Injury in Rabbit.
Background: We succeeded to set up a rabbit model of Ischemia-Reperfusion (I/R) injury to test future candidate substance or plant extract that may have anti-oxidant…2017 American Transplant Congress
A Clinically Relevant Protocol for Vascularized Composite Allotransplantation Using a Single Dose of AMD3100 for Stem Cell Mobilization.
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but application is limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols…2017 American Transplant Congress
Systemic Immunosuppression in the Setting of Ocular Surface Stem Cell Transplantation.
1University of Cincinnati, Cincinnati, OH; 2Cincinnati Eye Institute, Cincinnati, OH
Purpose: To evaluate the success, tolerability, and side effects of systemic immunosuppression (SI) in patients undergoing ocular surface stem cell transplantation (OSST) under the SI…2017 American Transplant Congress
In Vitro Optimisation of the Immunotherapeutic Effects of Umbilical Cord Derived MSC.
Mesenchymal stromal cells (MSC) possess immunomodulatory properties and are low immunogenic, which are both important for their development into an effective cellular immunotherapy after organ…2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…2017 American Transplant Congress
The Impact of Tracheal Epithelial Cells Apoptosis on the Biological Behavior of Bone Marrow Mesenchymal Stem Cells (BMSCs) in OB.
Background: During the development of obliterative bronchiolitis (OB), extensive extracellular matrix is deposited in the lumen of the bronchioli, and the number of myofibroblasts increases.…2016 American Transplant Congress
In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells – A Novel Approach for Tolerance Induction in Transplantation.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.
Background: Cell-based therapies represent a new promising approach for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…2016 American Transplant Congress
Inflammatory Conditions Switch the Effect of MSC on B Cells from Pro-Tolerogenic to Anti-Proliferative.
The immunomodulatory capacity of mesenchymal stem cells (MSC) makes them a promising therapeutic tool in transplantation. MSC are recently gaining interest for their immunomodulatory effects…2016 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cell Transplantation in a Cirrhotic Liver Rat Model.
Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Previous studies suggested that MSCs may ameliorate fibrogenesis through…
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