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Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies.

J. He,1 Z. Pan,1 X. Yuan,1 Y. Li,1 X. Wu,2 W. Zhu,2 X. Bao,1 Q. Zhao.2

1Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
2Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Meeting: 2016 American Transplant Congress

Abstract number: B68

Keywords: Antibodies, Donors, Graft-versus-host-disease, Stem cells, unrelated

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Disparities in Access and Outcomes

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Anti-HLA Antibodies in Allogeneic and Autologous Hematopoietic Stem Cell Transplantation.
  • Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients

The NMDP and CIBMTR provided guidelines for the use of anti-HLA antibodies in unrelated-donors hematopoietic stem cell transplantation (HSCT). However, a deeper understanding of other potentially useful biomarkers for predicting clinical outcomes in HLA-A, B, C, DRB1, DQB1, DQA1(12/12) matched unrelated-donors of HSCT is needed to further improve clinical outcomes. We tested HLA genotyping for 123 pairs of patients and donors. Anti-HLA antibodies using the Luminex method was applied to 123, 117 and 106 serum samples collected before and 1 month and 3 months after transplantation. The presences of anti-HLA antibodies at the 3 time-points were 37.4% (46/123), 40.2% (47/117), and 22.6% (24/106). Patients with anti-HLA antibodies had delayed platelet recovery. The presence of anti-HLA antibodies and their dynamic changes after transplantation were associated with increased occurrence of grade II-IV acute graft-versus-host disease (aGVHD) and chronic GVHD, higher treatment-related mortality (TRM), and reduced overall survival (OS) and disease-free survival (DFS), especially in acute myeloid leukemia and myelodysplastic syndrome patients. Multivariate analysis showed that anti-HLA antibodies before transplantation was a risk factor for GVHD and OS. Our results suggest that dynamic changes of anti-HLA antibodies predicted for negative outcome of HSCT. Routine monitoring for anti-HLA antibody dynamics should be conducted before and after HSCT.

CITATION INFORMATION: He J, Pan Z, Yuan X, Li Y, Wu X, Zhu W, Bao X, Zhao Q. Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

He J, Pan Z, Yuan X, Li Y, Wu X, Zhu W, Bao X, Zhao Q. Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/dynamic-detection-of-anti-hla-antibodies-can-predict-agvhd-and-os-in-hla-1212-matched-unrelated-donor-allo-hsct-for-hematological-malignancies/. Accessed March 4, 2021.

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