ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2020 American Transplant Congress

    Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice

    D. Choi1, D. Kim2, E. Kim2, J. Jeong2, J. Kim1, Y. Ham1, Y. Chang3, K. Na1, K. Lee1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, 3Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of

    *Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
  • 2020 American Transplant Congress

    Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts

    L. Mazilescu1, M. Kaths2, P. Urbanellis1, M. Hamar3, T. Goto1, I. Linares-Cervantes1, Y. Noguchi1, A. Konvalinka1, A. Ghanekar1, D. Bagli4, R. John5, L. Robinson6, M. Selzner1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, 3Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, 4Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, 5Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, 6Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
  • 2020 American Transplant Congress

    Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome

    R. Lathan1, R. Ghita1, R. Touyz1, M. Clancy2, P. Mark1

    1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, 2Renal Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    *Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
  • 2020 American Transplant Congress

    Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates

    C. Blanton1, J. Reyes1, M. Eerhart1, P. Chlebeck1, M. Springer1, Y. Ponstein2, E. vanAmersfoort2, J. Torrealba3, Y. Yankol1, A. D’Alessandro1, L. Fernandez1

    1University of Wisconsin, Madison, WI, 2Pharming Technologies BV, Leiden, Netherlands, 3Pathology, UTSouthwestern, Dallas, TX

    *Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
  • 2020 American Transplant Congress

    What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?

    K. Rozenberg1, L. Knijff1, J. Sierra-Parraga2, L. Lo Faro1, M. Hoogduijn2, C. Baan2, J. Hunter1, R. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
  • 2020 American Transplant Congress

    Reactivation of Murine Polyomavirus Replication by Renal Ischemia-Reperfusion Injury and Immunosuppression

    G. Huang1, Y. Huang1, X. Chen1, J. Qiu1, J. Li1, G. Li2, C. Wang1, L. Chen1

    1The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Guangdong Key Laboratory of Laboratory Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China

    *Purpose: Polyomavirus (PyV) nephropathy is an important cause of graft failure after renal transplantation. Its pathogenesis is associated with immunosuppression (IM) and renal ischemia-reperfusion injury…
  • 2020 American Transplant Congress

    Poly (ADP-Ribose) Polymerase Inhibitor Treatment Attenuated Renal Ischemia-Reperfusion Injury

    H. Jang, K. Lee, J. Jeon, J. Lee, Y. Kim, D. Kim, W. Huh

    Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

    *Purpose: Robust intrarenal inflammatory responses following ischemia-reperfusion injury (IRI) induce renal injury in ischemic acute kidney injury (AKI). We hypothesized that poly (ADP-Ribose) polymerase (PARP)…
  • 2020 American Transplant Congress

    Modulation of Ischemia Reperfusion Injury in Renal Transplantation Using Selective Estrogen Receptor Modulators

    P. T. Hernandez1, C. S. O'Brien1, S. J. Concors1, L. N. Krumeich1, W. Hancock2, M. H. Levine1

    1Hospital of the University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway

    Q. Yuan1, S. Hong1, E. Szuter1, Y. Zhao1, E. Acheampong1, I. Rosales1, M. Kronenberg2, P. Russell1, J. Madsen1, R. Colvin1, A. Alessandrini1

    1Massachusetts General Hospital, Boston, MA, 2La Jolla Institute for Allergy & Immunology, La Jolla, CA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
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