Articles tagged "Renal ischemia"

2020 American Transplant Congress
Effects of Kidney Transplantation on Cystogenesis in Kidneys Procured from a Deceased Donor with Autosomal Dominant Polycystic Kidney Disease
M. C. Chumley¹, H. Kim², D. M. Williams³, V. Kumar³, M. Mrug³
¹University of Alabama at Birmingham, Birmingham, AL, ²Radiology, University of Alabama at Birmingham, Birmingham, AL, ³Nephrology, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients are not routinely considered as kidney donors for renal transplantation. This is partially due to a concern…
2020 American Transplant Congress
Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury
S. Lan¹, B. Yang¹, J. Sabo-Vatasescu², M. Bourgault², A. Karakeussian-Rimbaud³, J. Turgeon³, S. Qi¹, N. Patey⁴, M. Dieudé⁵, M. Hébert¹
¹Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³CRCHUM, CDTRP, Montreal, QC, Canada, ⁴Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, ⁵CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
2020 American Transplant Congress
Cordycepin Protects Renal Ischemia/Reperfusion Injury Through Regulating Inflammation, Apoptosis and Oxidative Stress
C. Ding, W. Xue
Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
*Purpose: Cordycepin (3’-deoxyadenosine) is a naturally occurring adenosine analogue and onem of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus…
2020 American Transplant Congress
Kidneys from AKI Donors with Poor Long-Term Outcomes Present an Impaired Protein Expression for Cellular Stress and Repair
F. Neri¹, M. Lo Faro¹, C. Boffa¹, T. Surik¹, M. Kaisar¹, E. J. Sharples², J. P. Hunter¹, J. Lindeman³, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom, ²Oxford Transplant Centre, Oxford, United Kingdom, ³Department of Vascular Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands
*Purpose: The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was…
2020 American Transplant Congress
Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?
N. Parajuli, A. Khakurel
University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
2020 American Transplant Congress
Tissue Specificity and the Role of Lymphocytes in Estrogen-Mediated Protection from Renal Ischemia Reperfusion Injury
P. T. Hernandez, C. S. O'Brien, S. J. Concors, L. N. Krumeich, Z. Wang, G. Ge, W. Hancock, M. H. Levine
Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
D. Choi¹, D. Kim², E. Kim², J. Jeong², J. Kim¹, Y. Ham¹, Y. Chang³, K. Na¹, K. Lee¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
2020 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts
L. Mazilescu¹, M. Kaths², P. Urbanellis¹, M. Hamar³, T. Goto¹, I. Linares-Cervantes¹, Y. Noguchi¹, A. Konvalinka¹, A. Ghanekar¹, D. Bagli⁴, R. John⁵, L. Robinson⁶, M. Selzner¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, ⁶Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
2020 American Transplant Congress
Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome
R. Lathan¹, R. Ghita¹, R. Touyz¹, M. Clancy², P. Mark¹
¹Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ²Renal Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
C. Blanton¹, J. Reyes¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. vanAmersfoort², J. Torrealba³, Y. Yankol¹, A. D’Alessandro¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UTSouthwestern, Dallas, TX
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…