ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2020 American Transplant Congress

    Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation

    K. Rozenberg1, S. Lohmann2, M. Pool3, M. Eijken4, U. Møldrup5, B. Møller6, J. Sierra-Parraga7, M. Hoogduijn7, L. Lo Faro1, C. Moers3, J. Hunter1, A. Keller2, H. Leuvenink3, C. Baan7, R. Ploeg1, B. Jespersen2

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, 4Department of Renal Medicine, Aarhus University, Aarhus, Denmark, 5Department of Urology, Aarhus University, Aarhus, Denmark, 6Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, 7Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
  • 2020 American Transplant Congress

    Mir-124/ire-1α Affects Renal Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress in Renal Tubularepithelial Cells

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

    *Purpose: In this study, we investigated the protective functions of miR-124 on renal I/R injury both in vivo and in vitro and explored its underlying…
  • 2020 American Transplant Congress

    microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    *Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…
  • 2020 American Transplant Congress

    The Role of Ceria-Nanoparticles in Renal Ischemia Reperfusion Injury Models in Rats

    C. T. Chung, H. Ko, H. Kim, H. Mo, A. Han, S. Min, J. Ha

    Seoul National University, College of Medicine, Seoul, Korea, Republic of

    *Purpose: Preventing ischemia reperfusion injury (IRI) is an important issue in kidney transplantation, significantly related to graft survival. Ceria nanoparticles has antioxidant properties as a…
  • 2020 American Transplant Congress

    Effects of Kidney Transplantation on Cystogenesis in Kidneys Procured from a Deceased Donor with Autosomal Dominant Polycystic Kidney Disease

    M. C. Chumley1, H. Kim2, D. M. Williams3, V. Kumar3, M. Mrug3

    1University of Alabama at Birmingham, Birmingham, AL, 2Radiology, University of Alabama at Birmingham, Birmingham, AL, 3Nephrology, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients are not routinely considered as kidney donors for renal transplantation. This is partially due to a concern…
  • 2020 American Transplant Congress

    Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury

    S. Lan1, B. Yang1, J. Sabo-Vatasescu2, M. Bourgault2, A. Karakeussian-Rimbaud3, J. Turgeon3, S. Qi1, N. Patey4, M. Dieudé5, M. Hébert1

    1Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3CRCHUM, CDTRP, Montreal, QC, Canada, 4Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, 5CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
  • 2020 American Transplant Congress

    Cordycepin Protects Renal Ischemia/Reperfusion Injury Through Regulating Inflammation, Apoptosis and Oxidative Stress

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

    *Purpose: Cordycepin (3’-deoxyadenosine) is a naturally occurring adenosine analogue and onem of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus…
  • 2020 American Transplant Congress

    Kidneys from AKI Donors with Poor Long-Term Outcomes Present an Impaired Protein Expression for Cellular Stress and Repair

    F. Neri1, M. Lo Faro1, C. Boffa1, T. Surik1, M. Kaisar1, E. J. Sharples2, J. P. Hunter1, J. Lindeman3, R. Ploeg1

    1Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom, 2Oxford Transplant Centre, Oxford, United Kingdom, 3Department of Vascular Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands

    *Purpose: The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was…
  • 2020 American Transplant Congress

    Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?

    N. Parajuli, A. Khakurel

    University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
  • 2020 American Transplant Congress

    Tissue Specificity and the Role of Lymphocytes in Estrogen-Mediated Protection from Renal Ischemia Reperfusion Injury

    P. T. Hernandez, C. S. O'Brien, S. J. Concors, L. N. Krumeich, Z. Wang, G. Ge, W. Hancock, M. H. Levine

    Hospital of the University of Pennsylvania, Philadelphia, PA

    *Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…
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