ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal ischemia"

  • 2022 American Transplant Congress

    Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation

    A. Rossi1, S. Sedrakyan2, F. Montali3, C. Aardena4, N. Abraham5, A. Barbas5, L. N. Byers6, C. Palles7, A. Asthana6, J. Robertson4, L. Perin2, R. Senger4, B. Bussolati1, G. Orlando8

    1Un. of Turin, Turin, Italy, 2Children Hospital, Los Angeles, CA, 3Un. of L'Aquila, L'Aquila, Italy, 4VA Tech, Blacksburg, VA, 5Duke, Durham, NC, 6WFIRM, Winston Salem, NC, 7University of Florida, Gainesville, FL, 8Wake Forest Baptist, Winston-Salem, NC

    *Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
  • 2022 American Transplant Congress

    Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies

    L. Gallon1, J. K. Carrow2, J. He1, Y. Sambandam1, X. Lai1, J. Mathew1, L. C. Palmer2, J. R. Leventhal1, Z. Zhang1, S. I. Stupp2

    1Surgery - Transplant, Northwestern University, Chicago, IL, 2Simpson Querrey Institute, Northwestern University, Chicago, IL

    *Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
  • 2022 American Transplant Congress

    Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts

    X. Lai1, J. Wang1, S. Han1, C. Chunlei1, L. VanOsdol1, L. Gallon2, J. Leventhal2, M. Kandpal1, Z. Zhang1

    1Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
  • 2022 American Transplant Congress

    Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury

    S. Gharaie, K. Lee, S. Noel, L. Arend, H. Rabb

    Johns Hopkins Medicine, Baltimore, MD

    *Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…
  • 2022 American Transplant Congress

    QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF

    S. Ghosh1, H. Tedesco2, R. Sarwal1, N. Titzler1, W. Yazar1, M. Nakamura2, J. Pestana2, M. Sarwal1

    1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil

    *Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…
  • 2022 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Aggravate Inflammation and Renal Injury After Ischemia-Reperfusion

    I. Kaci1, S. Lan1, H. Kim1, A. Karakeussian Rimbaud1, F. Migneault1, J. Turgeon1, N. Patey2, M. Dieudé1, M. Hébert1

    1Research Centre, Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada, 2Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) and chronic kidney disease (CKD). Damage to microvascular peritubular capillaries (PTC) is…
  • 2022 American Transplant Congress

    Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis

    I. Husain, A. Dangi, X. Luo

    Duke University School of Medicine, Durham, NC

    *Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
  • 2022 American Transplant Congress

    The Role of HNF4α in Renal Ischemia Reperfusion Injury

    A. D. Saha

    Toronto General Hospital Research Institute, Toronto, ON, Canada

    *Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…
  • 2022 American Transplant Congress

    Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury but Pharmacologic Inhibition of Estrogen Receptor Beta is Not

    C. OBrien1, P. Hernandez2, S. Concors2, Z. Wang1, G. Ge1, W. Hancock3, M. Levine2

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Childrens Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Renal Ischemia Reperfusion Injury (IRI) contributes substantially to delayed graft function (DGF) in kidney transplantation. Prior work by our group has shown lower rates…
  • 2022 American Transplant Congress

    Implications of Accumulated Cold Time for US Kidney Transplantation Offer Acceptance

    M. Barah1, V. Kilambi2, J. Friedewald1, S. Mehrotra1

    1Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL, 2Department of Engineering and Applied Sciences, RAND Corporation, Arlington, VA

    *Purpose: Reducing discard is a current focus in US transplantation of deceased donor kidneys. One cause for the discards is the avoidance of protracted cold…
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