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American Transplant Congress abstracts

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Articles tagged "Renal injury"

  • 2021 American Transplant Congress

    Trends in the Recovery and Discard of Kidneys from Deceased Donors with Acute Kidney Injury from 2010-2018

    C. Liu1, S. Alasfar2, P. P. Reese3, S. Mohan4, M. D. Doshi5, I. E. Hall6, H. R. Thiessen-Philbrook2, Y. Jia2, D. E. Stewart7, C. Parikh2

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Perelman School of Medicine, Philadelphia, PA, 4New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, 5University of Michigan, Ann Arbor, MI, 6University of Utah School of Medicine, Salt Lake City, UT, 7United Network for Organ Sharing, Richmond, VA

    *Purpose: Since the donor KDPI score used in KAS is restricted to a single terminal serum creatinine (SCr) measurement, kidneys from donors with transient acute…
  • 2020 American Transplant Congress

    Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury

    J. Li, N. Rogers, S. Alexander

    Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia

    *Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
  • 2020 American Transplant Congress

    Zoledronate Induced AKI with Nephrotic Range Proteinuria in a Transplant Kidney

    S. Reddy, H. Khamash

    Nephrology, Mayo Clinic, Phoenix, AZ

    *Purpose: An unusual presentation of acute kidney injury with nephrotic range proteinuria following zoledronate in a normal functioning transplant kidney.*Methods: 61-year-old lady with history of…
  • 2020 American Transplant Congress

    Kidneys from AKI Donors with Poor Long-Term Outcomes Present an Impaired Protein Expression for Cellular Stress and Repair

    F. Neri1, M. Lo Faro1, C. Boffa1, T. Surik1, M. Kaisar1, E. J. Sharples2, J. P. Hunter1, J. Lindeman3, R. Ploeg1

    1Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom, 2Oxford Transplant Centre, Oxford, United Kingdom, 3Department of Vascular Surgery, Leiden University Medical Center (LUMC), Leiden, Netherlands

    *Purpose: The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was…
  • 2020 American Transplant Congress

    Urinary APOA4 as a Biomarker for Chronic Renal Allograft Injury and Rapid Renal Function Decline in Kidney Transplant Recipients

    H. Jeon1, D. Shin1, J. Oh1, J. Park2, K. Ko3, J. Kim3, S. Lee3

    1Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, 2Department of Laboratory Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, 3Department of Surgery, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of

    *Purpose: Chronic renal allograft injury (CRAI) remains a major cause of allograft loss in kidney transplant recipients (KTRs). The aim of this study was to…
  • 2020 American Transplant Congress

    Establishment of Spontaneous Tolerance of Kidney Allografts is Dependent on Mitigation of Ischemia-Reperfusion Injury via the BLTA-HVEM Pathway

    Q. Yuan1, S. Hong1, E. Szuter1, Y. Zhao1, E. Acheampong1, I. Rosales1, M. Kronenberg2, P. Russell1, J. Madsen1, R. Colvin1, A. Alessandrini1

    1Massachusetts General Hospital, Boston, MA, 2La Jolla Institute for Allergy & Immunology, La Jolla, CA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
  • 2020 American Transplant Congress

    Cordycepin Protects Renal Ischemia/Reperfusion Injury Through Regulating Inflammation, Apoptosis and Oxidative Stress

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

    *Purpose: Cordycepin (3’-deoxyadenosine) is a naturally occurring adenosine analogue and onem of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus…
  • 2020 American Transplant Congress

    Cyclo(His-Pro) Prevents Against Renal Injury Through Activating Nrf2-Mediated Pathway

    J. Moon1, Y. Kim1, H. Jung2, J. Kim1, W. Ju3, H. Lee1, J. Lee4, C. Lee5, D. Kim1, Y. Kim1, S. Yang6

    1Seoul National University Hospital, Seoul, Korea, Republic of, 2R&D Center, NovMetaPharma Co., Ltd, Pohang, Gyeongbuk, Korea, Republic of, 3Seoul National University Biomedical Research Institute, Seoul, Korea, Republic of, 4Nephrology Clinic, National Cancer Center, Goyang, Korea, Republic of, 5Cheju Halla General Hospital, Jeju-do, Korea, Republic of, 6Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Cyclic(His-Pro) (CHP) is an endogenous cyclic dipeptide that has antioxidative, anti-inflammatory effect via Nuclear factor erythroid 2-related factor (Nrf2) pathway. Endogenous CHP is distributed…
  • 2020 American Transplant Congress

    Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?

    N. Parajuli, A. Khakurel

    University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
  • 2020 American Transplant Congress

    Predictive Role of the Vitamin B12 in Acute Kidney Injury after Living Donor Liver Transplantation: A Retrospective Observational Cohort Study

    J. Park, M. Chae

    St.Mary's Hospital, Seoul, Seoul, Korea, Republic of

    *Purpose: The aim of our study is to examine the association between serum vitamin B12 level and development of postoperative acute kidney injury (AKI) in…
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