Articles tagged "Renal injury"

2021 American Transplant Congress
Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation
R. Lathan, P. Mark, M. Clancy, R. Touyz
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
A. Dangi¹, S. Yu², I. Husain¹, R. Geesala¹, X. Luo¹
¹Nephrology, Medicine, Duke University, Durham, NC, ²Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
2021 American Transplant Congress
Combining Oxygenated Cold Perfusion with Normothermic Ex-vivo Perfusion Improves the Outcome of DCD Porcine Kidney Transplantation
L. I. Mazilescu¹, T. Goto¹, R. Rosales¹, Y. Noguchi¹, P. Urbanellis¹, L. A. Robinson², M. Selzner¹
¹Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Ex-vivo machine perfusion is a novel preservation technique for the storage and assessment of marginal kidney grafts. Normothermic (NEVKP) as well as hypothermic machine…
2021 American Transplant Congress
Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection
R. Hinojosa¹, K. M. Hitchman², D. J. Ross³, R. C. Hall¹, J. E. Nelson¹, E. L. Kincaide¹, K. Klein¹, A. M. Bell³
¹Pharmacotherapy Education and Research Center | Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, ²Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, ³CareDx, Inc., Brisbane, CA
*Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…
2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
T. Salinas¹, C. Snopkowski¹, C. Li¹, K. Chen¹, M. Lubetzky¹, S. Salvatore¹, K. Van Besien¹, E. Jaimes², S. Hingorani³, S. Seshan¹, T. Muthukumar¹
¹NY Presbyterian- Weill Cornell Medical College, New York, NY, ²Memorial Sloan Kettering Cancer Center, New York, NY, ³University of Washington School of Medicine, Seattle, WA
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…
2021 American Transplant Congress
Influence of Immunosuppressant Management on Mortality in Kidney Transplant Recipients Hospitalized with COVID-19
Y. Fenig, A. Santeusanio, M. Menon, C. Liu, M. Rana, R. Shapiro
Mount Sinai Hospital, New York, NY
*Purpose: Kidney transplant recipients are thought to be at high risk for mortality from COVID-19 due to the necessity for chronic immunosuppressive therapy to prevent…
2021 American Transplant Congress
Trends in the Recovery and Discard of Kidneys from Deceased Donors with Acute Kidney Injury from 2010-2018
C. Liu¹, S. Alasfar², P. P. Reese³, S. Mohan⁴, M. D. Doshi⁵, I. E. Hall⁶, H. R. Thiessen-Philbrook², Y. Jia², D. E. Stewart⁷, C. Parikh²
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Perelman School of Medicine, Philadelphia, PA, ⁴New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, ⁵University of Michigan, Ann Arbor, MI, ⁶University of Utah School of Medicine, Salt Lake City, UT, ⁷United Network for Organ Sharing, Richmond, VA
*Purpose: Since the donor KDPI score used in KAS is restricted to a single terminal serum creatinine (SCr) measurement, kidneys from donors with transient acute…
2021 American Transplant Congress
Urine Donor-derived Cell-free is Valuable for Predicting BK Polyomavirus-associated Nephropathy in Kidney Transplant Recipients
G. Huang¹, X. Chen¹, Y. Huang¹, J. Li¹, R. Deng¹, W. Chen², J. Qiu¹, S. Deng¹, G. Chen¹, Q. Fu¹, C. Wu¹, J. Fei¹, L. Liu¹, L. Chen¹, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Our previous study has proved that urine donor-derived cell-free DNA (dd-cfDNA) can assist in the diagnosis of BK polyomavirus-associated nephropathy (BKPyVAN), but its specificity…
2021 American Transplant Congress
Hypercholesterolemia and Donor Age Impaired Capillary Vegf and Nitric Oxide (no) Expression and in Turn Decrease Both Microvascular Density and Tubule Villin Expression in Renal Allografts, Resulting in Poor Graft Survival
B. Ozdemir¹, E. Akcay¹, A. Ok Atilgan¹, M. Haberal²
¹Department of Pathology, Baskent University, Ankara, Turkey, ²Division of Transplantation, Department of General Surgery, Baskent University, Ankara, Turkey
*Purpose: The role of aging and hypercholesterolemia (HC) on endothelial cells (ECs) are not well defined. Aged ECs might produce less NO and VEGF, resulting…
2021 American Transplant Congress
Development of Novel Multivariable Logistic Regression Model for Predicting Acute Kidney Injury After Liver Transplantation
H. Chen, Y. Nie, Q. Zhao, X. He
Organ Transplant Center,, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Acute kidney injury (AKI) is a common early complication after liver transplantation, but there are no related predictive tools or models at present. The…