Articles tagged "Renal injury"

2020 American Transplant Congress
Oral versus Intravenous Mycophenolate Mofetil Administration: A Single Center Experience on Incidence of Acute Kidney Injury
P. Chung¹, K. Forrester², S. Ganesh¹
¹Division of Pulmonary Critical and Sleep Medicine, University of Southern California, Los Angeles, CA, ²Department of Clinical Pharmacy, University of Southern California School of Pharmacy, Los Angeles, CA
*Purpose: Mycophenolate mofetil (MMF) is one of the main immunosuppressive medications given in lung transplantation (LTx). It is given orally (PO) or intravenously (IV). In…
2020 American Transplant Congress
The Role of CXCL16/CXCR6 in Mediating Macrophage Chemotaxis and M1 Macrophage Polarization in Murine Renal Ischemia Reperfusion Injury
W. Zhang¹, X. Zhang², G. Tu², C. Yang¹, G. Qi¹, M. Xu¹, T. Zhu¹
¹Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China, ²Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: The objective of this study is to investigate the role of Chemokine (C-X-C motif) ligand 16 (CXCL16) and its unique receptor C-X-C chemokine receptor…
2020 American Transplant Congress
Acute Kidney Injury And Chronic Kidney Disease After Lung Transplantation: Incidence And Risk Factors In A Large Single-center Cohort
D. Abdelwahab, R. Marron, Z. Choudhry, I. Lee, J. Wu, J. Brown
Lewis Katz School of Medicine, Temple University, Philadelphia, PA
*Purpose: Chronic kidney disease (CKD) is a common complication after lung transplant. The reported incidence in small studies varies ranges from10-90%. Furthermore, data on risk…
2020 American Transplant Congress
Value of dd-cfDNA When Considering Recipient Ethnicity to Further to Help Risk Stratify Transplant Recipients
A. Langone¹, B. Fischbach², D. Cohen³
¹Vanderbilt Health, Nashville, TN, ²Baylor Scott & White Health, Fort Worth, TX, ³Columbia University, New York, NY
*Purpose: Within the modern era of kidney transplantation, African American (AA) transplant recipients continue to experience disproportionately higher rates of allograft loss. A combination of…
2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
E. B. Rangel¹, E. Higuti-Sousa¹, G. Goss², B. Goldstein², B. Seidler³, D. Saur³, S. A Gomes⁴, J. M. Hare²
¹Albert Einstein Hospital, São Paulo, Brazil, ²University of Miami, Miami, FL, ³Medizinische Klinik, Technische Universität München, Munich, Germany, ⁴University of São Paulo, São Paulo, Brazil
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…
2019 American Transplant Congress
Exendin-4 for Donor Treatment in a Brain-Death Model of Kidney Transplantation
H. Yang¹, L. Luo¹, X. Li¹, C. Long¹, Y. Shi², Y. Xiong³, M. Chen⁴, J. Gao⁵, H. Li⁶, Z. Wang⁶
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Vascular Surgery, People's hospital of Jiangxi Province, Nanchang, China, ⁶Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Renal grafts from brain death donors associated with poorer graft outcomes after kidney transplantation, hemodynamic and inflammatory mechanisms can account for brain death induce…
2019 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Preservation Consistently Improves Extreme Marginal Graft Function Compared to Hypothermic Machine Perfusion
P. Urbanellis¹, M. Hamar¹, I. Linares¹, D. Kollmann¹, S. Ganesh¹, F. Oquendo¹, M. Sharma¹, R. John¹, A. Ghanekar¹, I. Mucsi¹, D. Bagli², A. Konvalinka¹, L. Robinson³, M. Selzner¹
¹Multi-Organ Transplantation Program, University Health Network, Toronto, ON, Canada, ²Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP promoted improved marginal graft function compared to…
2019 American Transplant Congress
Targeting Pyroptosis in Brain-Dead Donors Improves Renal Function after Transplantation in Rat
H. Yang¹, Y. Shi², X. Li¹, L. Luo¹, C. Long¹, Y. Xiong³, M. Chen⁴, J. Gao⁴, H. Li⁵, Z. Wang⁵
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Pyroptosis is a form of programmed cell death include necrosis, nuclear condensation, and release of proinflammatory after caspase-1 activation. It is unknown whether pyroptosis…
2019 American Transplant Congress
Donation After Circulatory Death Kidneys With Prolonged Delayed Graft Function Present Widespread Metabolic And Translational Deficiencies At Time Of Retrieval
M. L. Lo Faro¹, K. Rozenberg¹, H. Huang¹, S. Maslau¹, H. Leuvenink², E. Sharples³, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University Medical Centre Groningen, Groningen, Netherlands, ³Oxford Transplant Centre, Oxford, United Kingdom
*Purpose: Delayed graft function (DGF) is acute renal failure post-transplant, commonly defined as the need for dialysis in the first week post-transplant. Injury at time…
2019 American Transplant Congress
Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.
Y. Kim¹, J. Moon¹, J. Jeong¹, J. Kim¹, S. Lee¹, M. Yu², C. Lee³, Y. Kim¹, S. Yang⁴
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…