2021 American Transplant Congress
Kidney Transplant Biopsy Findings After Covid-19
*Purpose: COVID-19 has been reported as a cause of kidney injury and data from published native kidney biopsy results demonstrate a variety of causes. To…2021 American Transplant Congress
Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding
*Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…2021 American Transplant Congress
Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)
Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…2021 American Transplant Congress
Late Subclinical Rejection and Borderline Rejection in Kidney Transplant Patients is Associated with Increased Incidence of Subsequent Clinical Rejections
*Purpose: The outcomes of inflammatory changes noted in late surveillance biopsies (1 year) is unclear.*Methods: Patients transplanted (live donor and deceased donor) at our center…2021 American Transplant Congress
Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…2021 American Transplant Congress
Combining Oxygenated Cold Perfusion with Normothermic Ex-vivo Perfusion Improves the Outcome of DCD Porcine Kidney Transplantation
*Purpose: Ex-vivo machine perfusion is a novel preservation technique for the storage and assessment of marginal kidney grafts. Normothermic (NEVKP) as well as hypothermic machine…2021 American Transplant Congress
Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection
*Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…2021 American Transplant Congress
Influence of Immunosuppressant Management on Mortality in Kidney Transplant Recipients Hospitalized with COVID-19
Mount Sinai Hospital, New York, NY
*Purpose: Kidney transplant recipients are thought to be at high risk for mortality from COVID-19 due to the necessity for chronic immunosuppressive therapy to prevent…
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