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Articles tagged "Renal injury"

  • 2021 American Transplant Congress

    Kidney Transplant Biopsy Findings After Covid-19

    E. Daniel1, S. Kudose2, D. J. Cohen1, L. Ratner3, V. D'Agati2, I. Batal2

    1Division of Nephrology, Columbia University Medical Center, NY, NY, 2Department of Pathology, Columbia University Medical Center, NY, NY, 3Department of Surgery, Columbia University Medical Center, NY, NY

    *Purpose: COVID-19 has been reported as a cause of kidney injury and data from published native kidney biopsy results demonstrate a variety of causes. To…
  • 2021 American Transplant Congress

    Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding

    P. Halloran1, J. Reeve1, G. Böhmig2, O. Viklicky3, M. Myslak4, G. Gupta5, &. the INTERCOMEX Study Group6

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Medical University of Vienna, Vienna, Austria, 3Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 4Pomeranian Medical University, Szczecin, Poland, 5Virginia Commonwealth University, Richmond, VA, 6., ., AB, Canada

    *Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…
  • 2021 American Transplant Congress

    Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)

    H. Zhang

    Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…
  • 2021 American Transplant Congress

    Late Subclinical Rejection and Borderline Rejection in Kidney Transplant Patients is Associated with Increased Incidence of Subsequent Clinical Rejections

    V. Viswanathan1, I. Melgarejo2, C. Puttarajappa2, P. Sood2, M. Molinari2, S. Hariharan2, C. Wu2, A. Sharma2, N. Shah2, R. Mehta2

    1Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The outcomes of inflammatory changes noted in late surveillance biopsies (1 year) is unclear.*Methods: Patients transplanted (live donor and deceased donor) at our center…
  • 2021 American Transplant Congress

    Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation

    R. Lathan, P. Mark, M. Clancy, R. Touyz

    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

    *Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
  • 2021 American Transplant Congress

    Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation

    A. Dangi1, S. Yu2, I. Husain1, R. Geesala1, X. Luo1

    1Nephrology, Medicine, Duke University, Durham, NC, 2Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
  • 2021 American Transplant Congress

    Combining Oxygenated Cold Perfusion with Normothermic Ex-vivo Perfusion Improves the Outcome of DCD Porcine Kidney Transplantation

    L. I. Mazilescu1, T. Goto1, R. Rosales1, Y. Noguchi1, P. Urbanellis1, L. A. Robinson2, M. Selzner1

    1Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Ex-vivo machine perfusion is a novel preservation technique for the storage and assessment of marginal kidney grafts. Normothermic (NEVKP) as well as hypothermic machine…
  • 2021 American Transplant Congress

    Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection

    R. Hinojosa1, K. M. Hitchman2, D. J. Ross3, R. C. Hall1, J. E. Nelson1, E. L. Kincaide1, K. Klein1, A. M. Bell3

    1Pharmacotherapy Education and Research Center | Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, 2Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, 3CareDx, Inc., Brisbane, CA

    *Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…
  • 2021 American Transplant Congress

    Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue

    T. Salinas1, C. Snopkowski1, C. Li1, K. Chen1, M. Lubetzky1, S. Salvatore1, K. Van Besien1, E. Jaimes2, S. Hingorani3, S. Seshan1, T. Muthukumar1

    1NY Presbyterian- Weill Cornell Medical College, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3University of Washington School of Medicine, Seattle, WA

    *Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…
  • 2021 American Transplant Congress

    Influence of Immunosuppressant Management on Mortality in Kidney Transplant Recipients Hospitalized with COVID-19

    Y. Fenig, A. Santeusanio, M. Menon, C. Liu, M. Rana, R. Shapiro

    Mount Sinai Hospital, New York, NY

    *Purpose: Kidney transplant recipients are thought to be at high risk for mortality from COVID-19 due to the necessity for chronic immunosuppressive therapy to prevent…
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