Articles tagged "Renal injury"

2022 American Transplant Congress
CD38 Knockout Mice Demonstrate Decreased Neutrophil Infiltration Following Renal Ischemia Reperfusion Injury
I. Woelfel¹, A. Ruffing¹, I. El-Ayachi¹, K. Washburn², S. Black¹, A. Schenk¹
¹Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH
*Purpose: Ischemia reperfusion injury (IRI) perpetuates inflammation and causes significant organ injury in solid organ transplantation. CD38 is a ectoenzyme widely expressed on lymphocytes with…
2022 American Transplant Congress
Early Post-Operative Thrombotic Microangiopathy in Deceased Donor Kidney Transplant: A Retrospective Case Series
R. Seneriz¹, A. Mattiazzi¹, G. Guerra¹, T. Harrington², M. Velasquez³
¹Miami Transplant Institute, Miami, FL, ²University of Miami, Miami, FL, ³Jackson Memorial Hospital, Miami, FL
*Purpose: Transplant associated thrombotic microangiopathy (TA-TMA) is characterized by endothelial injury along with thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and kidney graft dysfunction. It can be…
2022 American Transplant Congress
Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation
E. Hafiz¹, W. H. El-Maadawy², M. Hassan³, M. H. Badawy⁴, S. Eldahshan⁴, A. AbuSeada⁵
¹Clinical Research Laboratory Department, Theodor Bilharz Research Institute, Giza, Egypt, ²Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt, ³Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁴Urology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁵Anesthesia Department, Theodor Bilharz Research Institute, Giza, Egypt
*Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…
2022 American Transplant Congress
Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids
A. Kumar Gupta¹, E. Minocha¹, J. A. Wertheim¹, L. Gallon²
¹Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, ²Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
2022 American Transplant Congress
The Impact of COVID-19 on Renal Function of Kidney Transplant Recipients: A Three-Month Prospective Study
R. D. Foresto¹, H. Fagundes², V. Lafico², H. Tedesco Silva Junior², M. P. Cristelli¹, J. Pestana¹
¹Hospital do Rim, Sao Paulo, Brazil, ²Hospital do Rim, Universidade Federal de São Paulo, SAo Paulo, Brazil
*Purpose: This study aimed to assess changes in renal function during the acute disease and up to three months after the onset of symptoms among…
2021 American Transplant Congress
Real-time Donor-derived Cell-free Dna Kinetics Indicate Decreased “Molecular Injury” During Treatment of Acute Renal Allograft Rejection
R. Hinojosa¹, K. M. Hitchman², D. J. Ross³, R. C. Hall¹, J. E. Nelson¹, E. L. Kincaide¹, K. Klein¹, A. M. Bell³
¹Pharmacotherapy Education and Research Center | Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, ²Long School of Medicine, UT Health San Antonio | University Transplant Center, University Health, San Antonio, TX, ³CareDx, Inc., Brisbane, CA
*Purpose: Dd-cfDNA is a validated plasma analyte (t½~30 min) for surveillance of renal transplant (KT) rejection with limited reports characterizing response to acute allograft rejection…
2021 American Transplant Congress
Kidney Injury in Hematopoietic Cell Transplant (HCT) Recipients: Urinary Biomarkers to the Rescue
T. Salinas¹, C. Snopkowski¹, C. Li¹, K. Chen¹, M. Lubetzky¹, S. Salvatore¹, K. Van Besien¹, E. Jaimes², S. Hingorani³, S. Seshan¹, T. Muthukumar¹
¹NY Presbyterian- Weill Cornell Medical College, New York, NY, ²Memorial Sloan Kettering Cancer Center, New York, NY, ³University of Washington School of Medicine, Seattle, WA
*Purpose: Kidney injury is common in HCT recipients and can be the result of graft versus host/kidney disease. However, this has not been well characterized,…
2021 American Transplant Congress
Influence of Immunosuppressant Management on Mortality in Kidney Transplant Recipients Hospitalized with COVID-19
Y. Fenig, A. Santeusanio, M. Menon, C. Liu, M. Rana, R. Shapiro
Mount Sinai Hospital, New York, NY
*Purpose: Kidney transplant recipients are thought to be at high risk for mortality from COVID-19 due to the necessity for chronic immunosuppressive therapy to prevent…
2021 American Transplant Congress
Trends in the Recovery and Discard of Kidneys from Deceased Donors with Acute Kidney Injury from 2010-2018
C. Liu¹, S. Alasfar², P. P. Reese³, S. Mohan⁴, M. D. Doshi⁵, I. E. Hall⁶, H. R. Thiessen-Philbrook², Y. Jia², D. E. Stewart⁷, C. Parikh²
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Perelman School of Medicine, Philadelphia, PA, ⁴New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, ⁵University of Michigan, Ann Arbor, MI, ⁶University of Utah School of Medicine, Salt Lake City, UT, ⁷United Network for Organ Sharing, Richmond, VA
*Purpose: Since the donor KDPI score used in KAS is restricted to a single terminal serum creatinine (SCr) measurement, kidneys from donors with transient acute…
2021 American Transplant Congress
Urine Donor-derived Cell-free is Valuable for Predicting BK Polyomavirus-associated Nephropathy in Kidney Transplant Recipients
G. Huang¹, X. Chen¹, Y. Huang¹, J. Li¹, R. Deng¹, W. Chen², J. Qiu¹, S. Deng¹, G. Chen¹, Q. Fu¹, C. Wu¹, J. Fei¹, L. Liu¹, L. Chen¹, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Our previous study has proved that urine donor-derived cell-free DNA (dd-cfDNA) can assist in the diagnosis of BK polyomavirus-associated nephropathy (BKPyVAN), but its specificity…