Articles tagged "Renal injury"

2017 American Transplant Congress
Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.
M. Menon,¹ L. Liriano-Ward,² N. Philippe,¹ C. Wei,¹ W. Zhang,¹ Z. Yi,¹ K. Keung,² P. O'Connell,² B. Murphy.¹
¹Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, Westmead Millenium Institute, Sydney, NSW, Australia
The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
2017 American Transplant Congress
Postoperative Serum Lactate Dehydrogenase Is a "Troponin-Like" Marker of Renal Transplant Distress.
R. Steiner, J. Halldorson.
UCSD Center for Transplantation, University of California at San Diego, San Diego, CA
Lactate dehydrogenase (LDH) is plentiful in renal tubular cells and is released during tubular injury or death. It increases for several days to 1500-2000 U/L…
2017 American Transplant Congress
Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.
M. Thomas, G. Tardif, A. Melanger, P. Berna.
Balmes Transplantation, Marseille, France
Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2017 American Transplant Congress
Relationship of Liver Extraction Times to Early Allograft Dysfunction and Post-Transplant Kidney Injury.
D. Simpson, M. Gupta, C. McAllister, P. Porrett, D. Goldberg, M. Levine, K. Olthoff, A. Shaked, P. Abt.
Hospital of the University of Pennsylvania, Philadelphia, PA
Background: Donor extraction times for kidney allografts are associated with inferior kidney outcomes. We hypothesized that that longer donor liver extraction times would be associated…
2017 American Transplant Congress
Utility of Electron Microscopy in Kidney Transplant Biopsies.
J. Grodsky,¹ R. Craver,^1,2 I. Ashoor.²
¹LSUHSC, New Orleans, LA; ²Children's Hospital, New Orleans, LA
Background: Banff 2013 criteria recommends performing ultra-structural studies with electron microscopy (EM) in most kidney transplant (KT) biopsies if the technology is available. We aimed…
2016 American Transplant Congress
Reciprocal Effects of HDAC1 and HDAC2 Deletion on Renal Cold Ischemia Survival and Nuclear Co-Repressor Complex Expression.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ³Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2016 American Transplant Congress
NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.
K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹
¹Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea; ²Internal Medicine, Daejeon Saint Mary Hospital, College of Medicine, Catholic University, Daejeon, Korea.
Introduction: Recently mitochondrial damage has been known to play a major role in various renal injury mechanisms including ischemia-reperfusion (IR) renal injury. Mitochondrial injury and…
2016 American Transplant Congress
Acute Kidney Injury After Liver Transplantation Is Set in Motion Early After Reperfusion of the Liver Graft: A Prospective Cohort Study.
I. Jochmans,¹ N. Meurisse,² D. Monbaliu,¹ J. Pirenne.¹
¹Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium; ²Abdominal Transplant Surgery, University of Liège, Academic Hospital, Liège, Belgium.
Objective: Determine creatinine changes during liver transplantation and risk factors for acute kidney injury (AKI) in a prospective cohort study (NCT01333319).Background Data: AKI, a major…