Articles tagged "Renal injury"

2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2017 American Transplant Congress
Relationship of Liver Extraction Times to Early Allograft Dysfunction and Post-Transplant Kidney Injury.
D. Simpson, M. Gupta, C. McAllister, P. Porrett, D. Goldberg, M. Levine, K. Olthoff, A. Shaked, P. Abt.
Hospital of the University of Pennsylvania, Philadelphia, PA
Background: Donor extraction times for kidney allografts are associated with inferior kidney outcomes. We hypothesized that that longer donor liver extraction times would be associated…
2017 American Transplant Congress
Utility of Electron Microscopy in Kidney Transplant Biopsies.
J. Grodsky,¹ R. Craver,^1,2 I. Ashoor.²
¹LSUHSC, New Orleans, LA; ²Children's Hospital, New Orleans, LA
Background: Banff 2013 criteria recommends performing ultra-structural studies with electron microscopy (EM) in most kidney transplant (KT) biopsies if the technology is available. We aimed…
2017 American Transplant Congress
The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.
G. Weber,¹ N. Ambrosi,² F. Caro,² S. Beltramino,¹ A. Fernández,¹ I. Cabrera,¹ G. Hilchenbach,¹ D. Fernandez,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; ²CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; ³Fundación GADOR, Buenos Aires, Argentina
A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
2017 American Transplant Congress
Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.
J. Kim,¹ H. Ahn,² D. Kim,¹ S. Jung,¹ E. Park,¹ T. Lee,¹ C. Ihm,¹ S. Lee,¹ J. Moon,¹ Y. Kim,¹ K. Jeong.¹
¹Nephrology, Kyung Hee University Medical Center, Seoul, Korea; ²Surgery, Kyung Hee University Medical Center, Seoul, Korea
Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…
2017 American Transplant Congress
Efficacy of Calcineurin Inhibitors Transferring to Rapamycin in Live Kidney Transplantation from Old Donors to Young Recipients.
G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Calcineurin inhibitor(CNI) nephrotoxicity is one of the major reasons for chronic allograft injury in live kidney transplantation from old donors to young recipients. Therefore…
2017 American Transplant Congress
Pre-OLT CKD-3 Increases Post-OLT ESRD and AKI Impacts Early Post-OLT Survival.
G. Faddoul, L. Liriano-Ward, P. Chang, Y. Azzi, K. Chauhan, G. Nadkarni, V. Nair, R. Kent, S. Lerner, S. Coca, P. Heeger, S. Florman, S. Thomas, M. Menon.
Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, Irvington, NY
Current combined Liver-kidney allocation protocols allocate dual organs based on sustained glomerular filtration rates (eGFR) of 30ml/min or less. It is unclear whether milder renal…
2016 American Transplant Congress
Mining the Human Proteome for Monitoring Renal Transplant Injury.
T. Sigdel,¹ Y. Gao,² J. He,² A. Wang,¹ C. Nicora,² D. Smith,² W. Qian,² D. Camp,² M. Sarwal.¹
¹Surgery, University of California-San Francisco, San Francisco; ²Pacific Northwest National Laboratory, Richland.
The human urinary proteome reflects systemic and inherent renal injury perturbations and can be harnessed to define biomarkers for different kidney transplant injury states. Through…
2016 American Transplant Congress
YKL-40 Predicts Renal Recovery in Deceased-Donor Transplantation.
J. Puthumana,¹ I. Hall,¹ P. Reese,² B. Schröppel,³ F. Weng,⁴ H. Thiessen-Philbrook,¹ M. Doshi,⁵ V. Rao,¹ C. Lee,⁶ J. Elias,⁶ L. Cantley,¹ C. Parikh.¹
¹Yale University School of Medicine, New Haven, CT; ²Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; ³Section of Nephrology, University Hospital, Ulm, Germany; ⁴Saint Barnabas Medical Center, Livingston, NJ; ⁵Division of Nephrology, Wayne State University School of Medicine, Detroit, MI; ⁶School of Medicine and Biological Sciences, Brown University, Providence, RI.
Background Deceased-donor kidneys with acute kidney injury (AKI) are often discarded for fear of poor transplantation outcomes. Donor biomarkers that predict post-transplant renal recovery could…
2016 American Transplant Congress
Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.
B. Schroppel,¹ P. Heeger,² I. Hall,³ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹University Hospital, Ulm, Germany; ²Mount Sinai School of Medicine, New York; ³Program of Applied Translational Research, Yale University School of Medicine, New Haven; ⁴Wayne State University, Detroit; ⁵Barnabas Health, Livingston; ⁶University of Pennsylvania, Philadelphia.
Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…