ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Renal injury"

  • 2017 American Transplant Congress

    The Treatment of the Graft and the Recipient with α-Lipoic Acid Improves the Delay Graft Function Severity in the Human Kidney Transplant.

    G. Weber,1 N. Ambrosi,2 F. Caro,2 S. Beltramino,1 A. Fernández,1 I. Cabrera,1 G. Hilchenbach,1 D. Fernandez,1 C. Incardona,3 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina; 3Fundación GADOR, Buenos Aires, Argentina

    A previous pilot clinic trial had showed that treatment of the donor and recipient with a potent anti-oxidant such as α-lipoc acid (ALA) reduces the…
  • 2017 American Transplant Congress

    Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.

    J. Kim,1 H. Ahn,2 D. Kim,1 S. Jung,1 E. Park,1 T. Lee,1 C. Ihm,1 S. Lee,1 J. Moon,1 Y. Kim,1 K. Jeong.1

    1Nephrology, Kyung Hee University Medical Center, Seoul, Korea; 2Surgery, Kyung Hee University Medical Center, Seoul, Korea

    Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…
  • 2017 American Transplant Congress

    Efficacy of Calcineurin Inhibitors Transferring to Rapamycin in Live Kidney Transplantation from Old Donors to Young Recipients.

    G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Background Calcineurin inhibitor(CNI) nephrotoxicity is one of the major reasons for chronic allograft injury in live kidney transplantation from old donors to young recipients. Therefore…
  • 2017 American Transplant Congress

    Pre-OLT CKD-3 Increases Post-OLT ESRD and AKI Impacts Early Post-OLT Survival.

    G. Faddoul, L. Liriano-Ward, P. Chang, Y. Azzi, K. Chauhan, G. Nadkarni, V. Nair, R. Kent, S. Lerner, S. Coca, P. Heeger, S. Florman, S. Thomas, M. Menon.

    Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, Irvington, NY

    Current combined Liver-kidney allocation protocols allocate dual organs based on sustained glomerular filtration rates (eGFR) of 30ml/min or less. It is unclear whether milder renal…
  • 2017 American Transplant Congress

    The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.

    T. Yagisawa,1,2 T. Tanaka,1 N. Dvorina,1 A. Valujskikh,1 W. Baldwin 3rd,1 R. Fairchild.1

    1Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH; 2Urology, Tokyo Women's Medical University, Tokyo, Japan

    While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
  • 2017 American Transplant Congress

    A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.

    M. Xu,1 B. Banan,1 X. Wang,1 D. Chirumbole,1 B. Rabe,1 S. Garcia-Aroz,1 D. Nayak,1 Z. Zhang,1 J. Jia,1 G. Upadhya,1 J. Gaut,2 P. Manning,3 Y. Lin,1 W. Chapman.1

    1Department of Surgery, Washington University School of Medicine, St. Louis; 2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; 3Tioma Therapeutics, Inc, St. Louis

    PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
  • 2017 American Transplant Congress

    Hepatic Ischemia Reperfusion Injury After Liver Transplantation Is Associated with Acute Kidney Injury.

    S. Kubal,1 M. Anderson,2 J. Fridell,1 B. Ekser,1 T. Taber,2 P. Li,1 M. Ghabril,3 M. Lacerda,3 R. Mangus.1

    1Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; 2Department of Nephrology, Indiana University School of Medicine, Indianapolis, IN; 3Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN

    Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that severity of IRI correlates with…
  • 2016 American Transplant Congress

    Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.

    B. Schroppel,1 P. Heeger,2 I. Hall,3 M. Doshi,4 F. Weng,5 P. Reese,6 C. Parikh.3

    1University Hospital, Ulm, Germany; 2Mount Sinai School of Medicine, New York; 3Program of Applied Translational Research, Yale University School of Medicine, New Haven; 4Wayne State University, Detroit; 5Barnabas Health, Livingston; 6University of Pennsylvania, Philadelphia.

    Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…
  • 2016 American Transplant Congress

    Many Discarded Kidneys Are Similar to Kidneys Accepted for Transplantation as Judged by Their Histologic Lesions and Molecular AKI Scores.

    K. Famulski,1 J. Reeve,1 O. Aubert,2 A. Loupy,2 S. Niderhaus,3 J. Bromberg,3 P. Halloran.1

    1University of Alberta, Edmonton, Canada; 2Necker Hospital, Paris, France; 3University of Maryland, Baltimore.

    There is an increase in the number kidneys from older brain dead donors (DBD). Many are discarded based on conventional features (clinical or histology). Thus…
  • 2016 American Transplant Congress

    Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).

    I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, H. Raymond.

    Mayo Clinic, Phoenix, AZ.

    BackgroundTransplanting kidneys from donors with AKI is one of the methods to minimize the disparity between numbers of listed patient and donor pool. Our aim…
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