Articles tagged "Renal injury"

2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
M. Xu,¹ B. Banan,¹ X. Wang,¹ D. Chirumbole,¹ B. Rabe,¹ S. Garcia-Aroz,¹ D. Nayak,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ J. Gaut,² P. Manning,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Washington University School of Medicine, St. Louis; ²Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; ³Tioma Therapeutics, Inc, St. Louis
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
2017 American Transplant Congress
Hepatic Ischemia Reperfusion Injury After Liver Transplantation Is Associated with Acute Kidney Injury.
S. Kubal,¹ M. Anderson,² J. Fridell,¹ B. Ekser,¹ T. Taber,² P. Li,¹ M. Ghabril,³ M. Lacerda,³ R. Mangus.¹
¹Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; ²Department of Nephrology, Indiana University School of Medicine, Indianapolis, IN; ³Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN
Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that severity of IRI correlates with…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.
M. Menon,¹ L. Liriano-Ward,² N. Philippe,¹ C. Wei,¹ W. Zhang,¹ Z. Yi,¹ K. Keung,² P. O'Connell,² B. Murphy.¹
¹Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, Westmead Millenium Institute, Sydney, NSW, Australia
The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
2017 American Transplant Congress
Postoperative Serum Lactate Dehydrogenase Is a "Troponin-Like" Marker of Renal Transplant Distress.
R. Steiner, J. Halldorson.
UCSD Center for Transplantation, University of California at San Diego, San Diego, CA
Lactate dehydrogenase (LDH) is plentiful in renal tubular cells and is released during tubular injury or death. It increases for several days to 1500-2000 U/L…
2017 American Transplant Congress
Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.
M. Thomas, G. Tardif, A. Melanger, P. Berna.
Balmes Transplantation, Marseille, France
Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…
2016 American Transplant Congress
Comparing Renal Function After Liver Transplantation: Modified Piggyback versus Conventional Techniques without Venovenous Bypass.
J. Lee, J. Lee, S. Song, J. Lee, S.-K. Kwon, D. Han, M. Ju, G. Choi, J. Choi, M. Kim, S. Kim, D. Joo.
Surgery, Yonsei University College of Medicine, Seoul, Korea.
BackgroundThere are several options available for caval reconstruction in liver transplantation. Prior reports demonstrated that caval reconstruction technique could affect the renal function. However, there…
2016 American Transplant Congress
Impact of Donor AKI on Outcome Following High KDPI Deceased Donor Kidney Transplantation.
D. Haakinson,¹ I. Qaqish,² M. Smith,³ H. Khamash,² K. Reddy,¹ R. Heilman.²
¹Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ; ²Nephrology, Mayo Clinic Arizona, Phoenix, AZ; ³Pathology, Mayo Clinic Arizona, Phoenix, AZ.
Background: Transplanting deceased donor kidneys with AKI does not appear to have negative impact on graft survival, however the impact of AKI on high KDPI…
2016 American Transplant Congress
Donor AKI Does Not Adversely Affect the Outcome Following DCD Kidney Transplant.
I. Qaqish, D. Haakinson, K. Reddy, M. Smith, H. Khamash, R. Heilman.
Mayo Clinic, Phoenix, AZ.
BackgroundTransplanting kidneys from donation after cardiac death (DCD) donors has been associated with good outcome, but the impact of added donor AKI on the outcome…