Articles tagged "Renal injury"

2018 American Transplant Congress
End Stage Renal Disease after Face Transplant
N. Shockcor,¹ B. Buckingham,¹ W. Hassanein,¹ A. Haririan,¹ S. Roberts,² A. Nam,¹ E. Rodriguez,³ S. Bartlett,¹ R. Barth.¹
¹University of Maryland, Baltimore, MD; ²Ochsner Health Center, Covington, LA; ³New York University, New York, NY.
Purpose Renal failure as an outcome of chronic immunosuppression is a known complication of organ transplantation. We report the first case of end stage renal…
2018 American Transplant Congress
p16^INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury
A. Melk,¹ A. Baisantry,^1,2 S. Wang,¹ F. Kubaink,¹ R. Bhayadia,¹ R. Schmitt.²
¹Department of Kidney, Liver & Metabolic Diseases, MHH, Hannover, Germany; ²Department of Nephrology, MHH, Hannover, Germany.
Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…
2018 American Transplant Congress
Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function
K. Famulski, P. Halloran.
University of Alberta, Edmonton, Canada.
With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…
2018 American Transplant Congress
Acute Tubular and Glomerular Kidney Injury Markers Reflect Ischemia-Reperfusion and Rejection
Y. Shim, R. Fan, N. Dvorina, W. Baldwin.
Immunology, Cleveland Clinic, Cleveland, OH.
Reliable markers of early acute injury following renal transplantation would enable timely therapeutic interventions. Standard serum creatinine and blood urea nitrogen measurements increase only after…
2018 American Transplant Congress
Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model
L. Liu, X. Li, Q. Su, Z. Bi, H. Huang, C. Wang.
Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, New York, NY, China.
Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…
2018 American Transplant Congress
Vascular Allografts in Renal Transplantation
D. Reino, G. Schnickel, E. Ale, S. Ebaid, N. Agrawal, S. Rhazouani, S. Gebreselassie, A. Tzakis.
Solid Organ Transplantation, Cleveland Clinic Florida, Weston, FL.
Vascular allografts are used routinely in pancreas, intestine and occasionally in liver transplantation. We propose that selective use of vascular allografts may increase utilization of…
2018 American Transplant Congress
Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)
B. Fuhrmann,^1,5 D. Lian,⁵ Z. Yin,⁵ S. Ma,^4,5 J. Arp,⁵ Z. Zhang,^2,3,4,5 A. Jevnikar.^1,3,4,5
¹Microbiology and Immunology, Western University, London, Canada; ²Pathology, Western University, London, Canada; ³Medicine, Western University, London, Canada; ⁴Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; ⁵Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
2018 American Transplant Congress
Comparison of Temperatures for Optimal Preservation of Donor Kidneys during Oxygenated Pulsatile Perfusion
R. Bhattacharjee,¹ M. Richard-Mohamed,² A. Ruthirakanthan,³ R. Mayer,² S. Luke,³ H. Sharma,² M. TunAbraham,² B. Alharbi,² A. Haig,² P. Luke.^1,2,3
¹Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Western University, Canada, London, ON, Canada.
Background. The current methods of preserving DCD renal allografts in either static cold solution or hypothermic pulsatile perfusion are unable to adequately protect the kidney…
2018 American Transplant Congress
The Prognostic Implications of Renal Function Recovery and Delayed Graft Function in Kidney Transplantation
S. Sandal, M. Cantarovich, A. Ramankumar, N. Saberi, C. Saw, D. Baran, P. Chaudhury, S. Paraskevas, J. Tchervenkov.
MUHC, Montreal, Canada.
Introduction: Lack of renal function recovery (RFR), 90 days after acute kidney injury (AKI) is a contributor to inferior renal outcomes and mortality. Ischemia and…
2018 American Transplant Congress
Etiologies and Long-Term Outcomes of Acute Kidney Injury in Older Kidney Transplant Recipients
R. Rodriguez, P. Amechi, V. Rao, D. Taber, M. Posadas Salas.
Medical University of South Carolina, Charleston, SC.
Older kidney transplant recipients face challenges of post-transplant complications related to frailty and comorbidity burden. They are particularly vulnerable to acute kidney injury (AKI) due…

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