Articles tagged "Renal function"

2022 American Transplant Congress
Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation
A. Rossi¹, S. Sedrakyan², F. Montali³, C. Aardena⁴, N. Abraham⁵, A. Barbas⁵, L. N. Byers⁶, C. Palles⁷, A. Asthana⁶, J. Robertson⁴, L. Perin², R. Senger⁴, B. Bussolati¹, G. Orlando⁸
¹Un. of Turin, Turin, Italy, ²Children Hospital, Los Angeles, CA, ³Un. of L'Aquila, L'Aquila, Italy, ⁴VA Tech, Blacksburg, VA, ⁵Duke, Durham, NC, ⁶WFIRM, Winston Salem, NC, ⁷University of Florida, Gainesville, FL, ⁸Wake Forest Baptist, Winston-Salem, NC
*Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
2022 American Transplant Congress
Cytomegalovirus Prevention in Kidney and Pancreas Transplant Recipients: A Successful Pharmacist-Led Multidisciplinary Approach
J. Geyston, J. Dann, A. Doyle, A. Agarwal, K. Brayman, C. Shoemaker, C. Lester, S. Rao
University of Virginia Health, Charlottesville, VA
*Purpose: In response to high cytomegalovirus (CMV) infection and increasing ganciclovir (GCV)-resistance rate, a pharmacist-led multidisciplinary task force was created to manage CMV prophylaxis (ppx).…
2022 American Transplant Congress
Tocilizumab in Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients: A Case Series
B. Boonpheng¹, R. Bakthavatsalam², C. D. Blosser¹, I. C. De Castro¹, I. Gimferrer³, Y. Ng¹, N. Leca¹
¹Nephrology, University of Washington, Seattle, WA, ²Surgery, University of Washington, Seattle, WA, ³Bloodworks Northwest, Seattle, WA
*Purpose: The optimal treatment for chronic active antibody-mediated rejection (ca-AMR) remains unclear. Tocilizumab (TCZ), a monoclonal antibody against IL-6, has been proposed in ca-AMR treatment…
2022 American Transplant Congress
Impact of Delayed Graft Function in Donation After Circulatory Death Kidney Transplantation
J. Mello Offerni¹, H. Brar¹, D. Lee¹, M. Levine², M. Mandurah¹, S. Rim¹, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Donation after circulatory death (DCD) has been associated with higher rates of delayed graft function (DGF) when compared to donation after brain death (DBD).…
2022 American Transplant Congress
Donor Macrophage Depletion Improves Kidney Graft Function Despite Long Cold Ischemia
C. Jordan¹, A. Dangi², X. Luo¹
¹Duke University School of Medicine, Durham, NC, ²Medicine, Duke University, Durham, NC
*Purpose: Prolonged cold ischemia is a known risk factor for delayed graft function and poorer outcomes after kidney transplantation. Overcoming this obstacle is key to…
2022 American Transplant Congress
Gender Imbalance in Kidney Transplantation in Japan
Y. Nakagawa¹, M. Mieno², H. Date³, H. Sasaki³, Y. Takada⁴, T. Ito³, Y. Tanaka³, S. Horie⁴, D. Ogasa⁴
¹Department of Urology, Juntendo University, Tokyo, Japan, ²Jichi Medical University, Tochigi, Japan, ³The Japan Society for Transplantation Gender Equality Committee, Tokyo, Japan, ⁴Department of Urology,, Juntendo University, Tokyo, Japan
*Purpose: Japan has a chronic shortage of donors. Therefore, kidney transplantation between elderly couples has increased. We examined how differences in gender and donor age…
2022 American Transplant Congress
Twelve Month Outcomes of Kidney Transplantation from Hepatitis C Viremic Deceased Donors to Aviremic Recipients
L. A. Binari, R. C. Forbes, S. Rega, I. D. Feurer, A. Dreher, S. Shawar, H. Schaefer, D. Shaffer, B. P. Concepcion
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The utilization of Hepatitis C viremic (HCV+) deceased donor kidneys for uninfected recipients allows for increased opportunities for organ transplantation. Initial studies have indicated…
2022 American Transplant Congress
The Role of HNF4α in Renal Ischemia Reperfusion Injury
A. D. Saha
Toronto General Hospital Research Institute, Toronto, ON, Canada
*Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…
2022 American Transplant Congress
Adherence, Outcomes and Adverse Effects in Pediatric Renal Transplant Patients After Early Steroid-Withdrawal and Low-Dose Calcineurin Inhibitor Maintenance Immunosuppression
A. Garcia¹, R. Plews¹, M. Moran¹, F. Trujillo¹, A. Martinez¹, N. Koizumi², D. Conti¹, J. Ortiz¹
¹Albany Medical College, Albany, NY, ²George Mason University, Arlington, VA
*Purpose: To explore adherence and long-term impacts of a sirolimus-based, low-dose calcineurin inhibitor regimen with early steroid withdrawal in pediatric renal transplant recipients.*Methods: A single-center,…
2022 American Transplant Congress
Diabetes Mellitus and Blood Glucose Variability Increases the 30-day Readmission Rate After Kidney Transplantation
H. Chakkera¹, C. Cook¹, S. Saghafian², A. Orfanoudaki³
¹Mayo Clinic Arizona, Scottsdale, AZ, ²Harvard University, Boston, MA, ³University of Oxford, Oxford, United Kingdom
*Purpose: The 30-day readmission rate is a surrogate metric of quality of care and mortality after kidney transplantation. Diabetes and observations of glucose variability during…