Articles tagged "Renal function"

2022 American Transplant Congress
Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation
E. Hafiz¹, W. H. El-Maadawy², M. Hassan³, M. H. Badawy⁴, S. Eldahshan⁴, A. AbuSeada⁵
¹Clinical Research Laboratory Department, Theodor Bilharz Research Institute, Giza, Egypt, ²Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt, ³Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁴Urology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁵Anesthesia Department, Theodor Bilharz Research Institute, Giza, Egypt
*Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…
2021 American Transplant Congress
Impact of Valganciclovir Prophylaxis Dosing in High Risk Cytomegalovirus Kidney and Pancreas Transplant Recipients with Delayed Graft Function
A. Gharabagi¹, J. Geyston¹, A. Agarwal², S. Rao³, A. Doyle³, J. Dann¹
¹Pharmacy, University of Virginia Health System, Charlottesville, VA, ²Transplant Surgery, University of Virginia Health System, Charlottesville, VA, ³Transplant Nephrology, University of Virginia Health System, Charlottesville, VA
*Purpose: We sought to compare outcomes of cytomegalovirus (CMV) prophylaxis in high risk CMV (donor +/recipient -) kidney and pancreas transplant recipients who received different…
2021 American Transplant Congress
Trends in the Recovery and Discard of Kidneys from Deceased Donors with Acute Kidney Injury from 2010-2018
C. Liu¹, S. Alasfar², P. P. Reese³, S. Mohan⁴, M. D. Doshi⁵, I. E. Hall⁶, H. R. Thiessen-Philbrook², Y. Jia², D. E. Stewart⁷, C. Parikh²
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Perelman School of Medicine, Philadelphia, PA, ⁴New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, ⁵University of Michigan, Ann Arbor, MI, ⁶University of Utah School of Medicine, Salt Lake City, UT, ⁷United Network for Organ Sharing, Richmond, VA
*Purpose: Since the donor KDPI score used in KAS is restricted to a single terminal serum creatinine (SCr) measurement, kidneys from donors with transient acute…
2021 American Transplant Congress
Superior Metabolic Function of Type 2 Diabetes Mellitus Patients After Simultaneous Kidney/pancreas Transplantation Compared with Kidney Transplantation Alone
X. Y. Fu, C. Yu, H. Wang, J. Zhao, Z. Wang, C. Mo, X. Shi, G. Feng, W. Song, Z. Shen
Tianjin First Centeral Hospital, Tianjin, China
*Purpose: To compare the renal function, metabolic profiles and survival outcomes of simultaneous pancreas kidney transplantation (SPK) and kidney transplantation alone (KTA) to end-stage renal…
2021 American Transplant Congress
Tolerability of De Novo and Conversion Belatacept Regimens in Kidney Transplantation
T. Le¹, J. Shoji², J. Phillips¹, D. Quan¹
¹Pharmaceutical Services, UCSF Medical Center, San Francisco, CA, ²Transplant Nephrology, UCSF Medical Center, San Francisco, CA
*Purpose: Belatacept, a selective T lymphocyte co-stimulation blocker, has been shown to be a safe and effective maintenance therapy for immunosuppression. We investigated the long-term…
2021 American Transplant Congress
Kidney Transplant Outcomes Stratified by Race with a Calcineurin and Steroid Free Regimen
R. E. Scalzo, M. T. Harris, J. D. Morris, J. S. Byrns
Pharmacy, Duke University Medical Center, Durham, NC
*Purpose: This study aimed to describe the outcomes, stratified by race, associated with belatacept and sirolimus immunosuppression after alemtuzumab induction.*Methods: This was a retrospective, single-center…
2021 American Transplant Congress
A Multi-institutional Study of Renal Outcomes in Uterus Transplantation
D. Sawinski¹, L. Johannesson², J. Kristen³, J. Fronek³, P. Porrett⁴
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Department of Surgery, Baylor University Medical Center, Dallas, TX, ³Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴University of Alabama at Birmingham, Birmingham, AL
*Purpose: Pregnancy and calcineurin inhibitor-based immunosuppression represent potential renal stressors for uterus transplant (UTx) recipients, many of whom have Mayer-Rokitanksy-Kuster-Hauser (MRKH) syndrome and associated renal…
2021 American Transplant Congress
Early Experience with Machine Retrograde Perfusion of Deceased Donor Kidneys: Short-term Outcomes of a Prospective Study
J. Zeng, Q. Zhong, S. Yin, Z. Jia, Z. Huang, Y. Fan, X. Wang, T. Lin, T. Song
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: To maximize the utilization of potential kidneys, improving perfusion and preservation technique is necessary. This article mainly investigated the safety and efficacy of retrograde…
2021 American Transplant Congress
When is the Optimal Time to Initiate the Renal-Sparing Protocol with Calcineurin Inhibitor Withdrawal?
N. Patel, M. Kittleson, J. Patel, T. Singer-Englar, S. Kim, D. Chang, B. Azarbal, A. Nikolova, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Renal dysfunction after heart transplantation (HTx) has been associated with higher morbidity and mortality. The most common cause of this renal dysfunction is the…
2021 American Transplant Congress
Treatment of Refractory Chronic Active Antibody-Mediated Rejection: Improvement in Histopathology are Delayed Compared to the Reduction in Donor Specific Antibodies
K. R. Degner¹, S. Parajuli¹, F. Aziz¹, N. Garg¹, M. Mohamed¹, D. A. Mandelbrot¹, S. E. Panzer¹, L. Hidalgo¹, N. A. Wilson¹, S. R. Reese¹, K. Van Hyfte¹, W. Zhong¹, P. Nickerson², A. Djamali¹
¹University of Wisconsin, Madison, WI, ²University of Manitoba, Winnipeg, MB, Canada
*Purpose: There are limited options for the treatment and management of refractory chronic active antibody-mediated rejection (cABMR) after kidney transplantation. Longitudinal histologic data in patients…