Articles tagged "Renal function"

2022 American Transplant Congress
Donor Macrophage Depletion Improves Kidney Graft Function Despite Long Cold Ischemia
C. Jordan¹, A. Dangi², X. Luo¹
¹Duke University School of Medicine, Durham, NC, ²Medicine, Duke University, Durham, NC
*Purpose: Prolonged cold ischemia is a known risk factor for delayed graft function and poorer outcomes after kidney transplantation. Overcoming this obstacle is key to…
2022 American Transplant Congress
Gender Imbalance in Kidney Transplantation in Japan
Y. Nakagawa¹, M. Mieno², H. Date³, H. Sasaki³, Y. Takada⁴, T. Ito³, Y. Tanaka³, S. Horie⁴, D. Ogasa⁴
¹Department of Urology, Juntendo University, Tokyo, Japan, ²Jichi Medical University, Tochigi, Japan, ³The Japan Society for Transplantation Gender Equality Committee, Tokyo, Japan, ⁴Department of Urology,, Juntendo University, Tokyo, Japan
*Purpose: Japan has a chronic shortage of donors. Therefore, kidney transplantation between elderly couples has increased. We examined how differences in gender and donor age…
2022 American Transplant Congress
Twelve Month Outcomes of Kidney Transplantation from Hepatitis C Viremic Deceased Donors to Aviremic Recipients
L. A. Binari, R. C. Forbes, S. Rega, I. D. Feurer, A. Dreher, S. Shawar, H. Schaefer, D. Shaffer, B. P. Concepcion
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The utilization of Hepatitis C viremic (HCV+) deceased donor kidneys for uninfected recipients allows for increased opportunities for organ transplantation. Initial studies have indicated…
2022 American Transplant Congress
The Role of HNF4α in Renal Ischemia Reperfusion Injury
A. D. Saha
Toronto General Hospital Research Institute, Toronto, ON, Canada
*Purpose: Ischemia reperfusion injury (IRI) affects all solid organ transplants and impairs renal graft function. However, the mechanisms by which IRI affects grafts are incompletely…
2022 American Transplant Congress
Adherence, Outcomes and Adverse Effects in Pediatric Renal Transplant Patients After Early Steroid-Withdrawal and Low-Dose Calcineurin Inhibitor Maintenance Immunosuppression
A. Garcia¹, R. Plews¹, M. Moran¹, F. Trujillo¹, A. Martinez¹, N. Koizumi², D. Conti¹, J. Ortiz¹
¹Albany Medical College, Albany, NY, ²George Mason University, Arlington, VA
*Purpose: To explore adherence and long-term impacts of a sirolimus-based, low-dose calcineurin inhibitor regimen with early steroid withdrawal in pediatric renal transplant recipients.*Methods: A single-center,…
2022 American Transplant Congress
Diabetes Mellitus and Blood Glucose Variability Increases the 30-day Readmission Rate After Kidney Transplantation
H. Chakkera¹, C. Cook¹, S. Saghafian², A. Orfanoudaki³
¹Mayo Clinic Arizona, Scottsdale, AZ, ²Harvard University, Boston, MA, ³University of Oxford, Oxford, United Kingdom
*Purpose: The 30-day readmission rate is a surrogate metric of quality of care and mortality after kidney transplantation. Diabetes and observations of glucose variability during…
2022 American Transplant Congress
Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation
E. Hafiz¹, W. H. El-Maadawy², M. Hassan³, M. H. Badawy⁴, S. Eldahshan⁴, A. AbuSeada⁵
¹Clinical Research Laboratory Department, Theodor Bilharz Research Institute, Giza, Egypt, ²Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt, ³Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁴Urology Department, Theodor Bilharz Research Institute, Giza, Egypt, ⁵Anesthesia Department, Theodor Bilharz Research Institute, Giza, Egypt
*Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…
2022 American Transplant Congress
Outcome of Pre-Emptive Kidney Transplantation in Children Under 6 Years of Age; A Single Center Experience in Japan
Y. Aoki¹, Y. Hamasaki¹, J. Hashimoto¹, A. Zaitsu², M. Kubota¹, M. Muramatsu¹, T. Kawamura¹, S. Shishido², K. Sakai¹
¹Nephrology, Toho University Faculty of Medicine, Tokyo, Japan, ²Pediatric Nephrology, Toho University Faculty of Medicine, Tokyo, Japan
*Purpose: Kidney transplantation (KT) is the preferred treatment for pediatric end stage renal disease, and pre-emptive kidney transplantation (PEKT) may reduce morbidity and mortality. KT…
2022 American Transplant Congress
The Renin Angiotensin System (RAS) After Pig-to-Baboon Kidney Transplantation
C. Hansen-Estruch¹, M. H. Bikhet¹, M. Javed¹, D. Ayares², A. Katsurada³, R. Satou³, W. Shao³, D. K. Cooper¹, L. G. Navar³, E. Judd⁴
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Revivicor, Blacksburg, VA, ³Department of Physiology and Hypertension and Renal Center, Tulane University, New Orleans, LA, ⁴Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Relatively long-term survival after life-supporting pig-to-baboon kidney transplantation has been achieved. However, there are documented episodes of hypovolemia during the post-transplant period from an…
2022 American Transplant Congress
Basiliximab Provides Similar Efficacy and Renal Recovery in Steroid-Minimal Liver Transplantation
L. Bowman¹, A. Webb¹, Y. Alsalihi², F. Fakhre³, R. Baliga⁴, V. Subramanian⁵, K. Robichaux³, S. Mohammed³, M. Gosselin⁶, J. Buggs⁵, A. Kumar⁷
¹Transplant Pharmacy, Tampa General Hospital, Tampa, FL, ²California Health Sciences University, Clovis, CA, ³University of South Florida, Tampa, FL, ⁴Florida Kidney Physicians, Tampa, FL, ⁵Transplant Surgery, Tampa General Hospital, Tampa, FL, ⁶University of Tampa, Tampa, FL, ⁷Morsani College of Medicine, University of South Florida, Tampa, FL
*Purpose: Due to nephrotoxic effects of tacrolimus, previous studies have evaluated the utility of basiliximab to delay or reduce tacrolimus for renal preservation in orthotopic…